ENTRY ko00984 Pathway NAME Steroid degradation CLASS Metabolism; Xenobiotics biodegradation and metabolism PATHWAY_MAP ko00984 Steroid degradation DBLINKS GO: 0006707 ORTHOLOGY K03333 cholesterol oxidase [EC:1.1.3.6] K16045 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] K15981 cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29] K16046 cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.28] K05898 3-oxosteroid 1-dehydrogenase [EC:1.3.99.4] K15982 3-ketosteroid 9alpha-monooxygenase subunit A [EC:1.14.15.30] K15983 3-ketosteroid 9alpha-monooxygenase subunit B [EC:1.14.15.30] K16047 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase [EC:1.14.14.12] K16048 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase reductase component [EC:1.5.1.-] K16049 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25] K16050 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase [EC:3.7.1.17] K18687 HIP---CoA ligase [EC:6.2.1.41] K05296 3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51] K01822 steroid Delta-isomerase [EC:5.3.3.1] K16051 3-oxo-5alpha-steroid 4-dehydrogenase [EC:1.3.99.5] COMPOUND C00187 Cholesterol C00280 Androstenedione C00535 Testosterone C00599 Cholest-4-en-3-one C00674 5alpha-Androstane-3,17-dione C01227 Dehydroepiandrosterone C04793 3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione C04844 3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate C07635 Epiandrosterone C11354 2-Hydroxy-cis-hex-2,4-dienoate C14909 9alpha-Hydroxyandrosta-1,4-diene-3,17-dione C19944 3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione C20144 Androsta-1,4-diene-3,17-dione C20199 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate C20252 5-Androstene-3,17-dione C20838 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA C20839 (25R)-3-Oxocholest-4-en-26-oate C21076 Delta4-Dafachronic acid REFERENCE PMID:21924910 AUTHORS Ouellet H, Johnston JB, de Montellano PR TITLE Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis. JOURNAL Trends Microbiol 19:530-9 (2011) DOI:10.1016/j.tim.2011.07.009 REFERENCE PMID:17264217 AUTHORS Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD TITLE A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. JOURNAL Proc Natl Acad Sci U S A 104:1947-52 (2007) DOI:10.1073/pnas.0605728104 REFERENCE PMID:22045806 AUTHORS Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS TITLE Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism. JOURNAL J Biol Chem 286:43668-78 (2011) DOI:10.1074/jbc.M111.313643 REFERENCE PMID:20889498 AUTHORS Driscoll MD, McLean KJ, Levy C, Mast N, Pikuleva IA, Lafite P, Rigby SE, Leys D, Munro AW TITLE Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. JOURNAL J Biol Chem 285:38270-82 (2010) DOI:10.1074/jbc.M110.164293 REFERENCE PMID:20843794 AUTHORS Johnston JB, Ouellet H, Ortiz de Montellano PR TITLE Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses. JOURNAL J Biol Chem 285:36352-60 (2010) DOI:10.1074/jbc.M110.161117 REFERENCE PMID:17630785 AUTHORS Yang X, Dubnau E, Smith I, Sampson NS TITLE Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. JOURNAL Biochemistry 46:9058-67 (2007) DOI:10.1021/bi700688x REFERENCE PMID:19875455 AUTHORS Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD TITLE Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism. JOURNAL J Biol Chem 285:434-43 (2010) DOI:10.1074/jbc.M109.058081 REFERENCE PMID:19843168 AUTHORS Kreit J, Sampson NS TITLE Cholesterol oxidase: physiological functions. JOURNAL FEBS J 276:6844-56 (2009) DOI:10.1111/j.1742-4658.2009.07378.x REFERENCE PMID:21056662 AUTHORS Horinouchi M, Hayashi T, Kudo T TITLE Steroid degradation in Comamonas testosteroni. JOURNAL J Steroid Biochem Mol Biol 129:4-14 (2012) DOI:10.1016/j.jsbmb.2010.10.008 REFERENCE PMID:20554032 AUTHORS Horinouchi M, Kurita T, Hayashi T, Kudo T TITLE Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot. JOURNAL J Steroid Biochem Mol Biol 122:253-63 (2010) DOI:10.1016/j.jsbmb.2010.06.002 REL_PATHWAY ko00100 Steroid biosynthesis ko00140 Steroid hormone biosynthesis ko00622 Xylene degradation ///