ENTRY ko00984 Pathway NAME Steroid degradation CLASS Metabolism; Xenobiotics biodegradation and metabolism PATHWAY_MAP ko00984 Steroid degradation DBLINKS GO: 0006707 ORTHOLOGY K00632 fadA, fadI; acetyl-CoA acyltransferase [EC:2.3.1.16] K01796 AMACR, mcr; alpha-methylacyl-CoA racemase [EC:5.1.99.4] K01822 ksi; steroid Delta-isomerase [EC:5.3.3.1] K03333 choD; cholesterol oxidase [EC:1.1.3.6] K05296 E1.1.1.51; 3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51] K05898 kstD; 3-oxosteroid 1-dehydrogenase [EC:1.3.99.4] K15981 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29] K15982 kshA; 3-ketosteroid 9alpha-monooxygenase subunit A [EC:1.14.15.30] K15983 kshB; 3-ketosteroid 9alpha-monooxygenase subunit B [EC:1.14.15.30] K16045 hsd; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] K16046 CYP142; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.28] K16047 hsaA; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase [EC:1.14.14.12] K16048 hsaB; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase reductase component [EC:1.5.1.-] K16049 hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25] K16050 hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase [EC:3.7.1.17] K16051 tesI; 3-oxo-5alpha-steroid 4-dehydrogenase [EC:1.3.99.5] K18364 bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase [EC:4.2.1.80 4.2.1.132] K18365 bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43] K18366 bphJ, xylQ, nahO, tesF; acetaldehyde/propanal dehydrogenase [EC:1.2.1.10 1.2.1.87] K18687 fadD3; HIP---CoA ligase [EC:6.2.1.41] K18688 fadD19; 3-oxocholest-4-en-26-oate---CoA ligase [EC:6.2.1.42] K22818 fadE26; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit [EC:1.3.99.-] K22819 fadE27; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase beta subunit [EC:1.3.99.-] K22820 fadE34; 3-oxochol-4-en-24-oyl-CoA dehydrogenase [EC:1.3.99.-] K22821 fadE28; 3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase alpha subunit [EC:1.3.99.-] K22822 fadE29; 3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase beta subunit [EC:1.3.99.-] K25621 chsH2; 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase alpha subunit K25622 chsH1; 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase beta subunit K25623 ltp2; 17-hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA lyase K28218 chsH3; 3-oxochol-4,22-dien-24-oyl-CoA hydratase (S-form) K28219 chsB1, hsd4A; (22S)-hydroxy-3-oxochol-4-en-24-oyl-CoA dehydrogenase K28220 scdG, IpdF; hydroxylacyl dehydrogenase K28221 scdC1, fadE33, ipdE2; 5OH-HIP-CoA dehydrogenase K28222 scdC2, fadE30, ipdE1; 5OH-HIP-CoA dehydrogenase K28224 scdD; enoyl-CoA hydratase K28225 scdE; 3-hydroxyl acyl-CoA dehydrogenase K28226 scdK, ipdC; acyl-CoA dehydrogenase K28227 scdY, echA20; HIEC-CoA hydrolase K28228 scdL1, ipdA; COCHEA-CoA hydrolase alpha subunit K28229 scdL2, ipdB; COCHEA-CoA hydrolase beta subunit K28230 scdM1, fadE31; acyl-CoA dehydrogenase K28231 scdM2, fadE32; acyl-CoA dehydrogenase K28232 scdN; enoyl-CoA hydratase COMPOUND C00022 Pyruvate C00024 Acetyl-CoA C00091 Succinyl-CoA C00100 Propanoyl-CoA C00187 Cholesterol C00280 Androstenedione C00479 Propanal C00535 Testosterone C00599 Cholest-4-en-3-one C00674 5alpha-Androstane-3,17-dione C01227 Dehydroepiandrosterone C04793 3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione C04844 3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate C06762 4-Hydroxy-2-oxohexanoic acid C07635 Epiandrosterone C11354 2-Hydroxy-cis-hex-2,4-dienoate C14909 9alpha-Hydroxyandrosta-1,4-diene-3,17-dione C19944 3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione C20144 Androsta-1,4-diene-3,17-dione C20199 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate C20252 5-Androstene-3,17-dione C20838 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA C20839 (25R)-3-Oxocholest-4-en-26-oate C20840 (25S)-3-Oxocholest-4-en-26-oyl-CoA C21076 Delta4-Dafachronic acid C21906 3-Oxochol-4-en-24-oyl-CoA C23003 3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]propanoyl-CoA C23004 (2E)-3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]prop-2-enoyl-CoA C23005 3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA C23006 3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA C23007 (3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-indene-4-carboxyl-CoA C23009 (7aS)-7a-Methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-4-carboxyl-CoA C23010 3-Oxocholest-4,24-dien-26-oyl-CoA C23011 (25R)-3-Oxocholest-4-en-26-oyl-CoA C23012 24-Hydroxy-3-oxocholest-4-en-26-oyl-CoA C23013 3,24-Dioxocholest-4-en-26-oyl-CoA C23014 3-Oxochol-4,22-dien-24-oyl-CoA C23015 (22S)-Hydroxy-3-oxochol-4-en-24-oyl-CoA C23016 3,22-Dioxochol-4-en-24-oyl-CoA C23017 3-Oxopregnene-20-carboxyl-CoA C23018 3-Oxo-4,17-pregnadiene-20-carboxyl-CoA C23019 17-Hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA C23020 (3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA C23021 9-Carboxy-6-methyl-3,7-dioxononanoyl-CoA C23022 7-Carboxy-4-methyl-5-oxoheptanoyl-CoA C23023 (2E)-7-Carboxy-4-methyl-5-oxohept-2-enoyl-CoA C23024 7-Carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA C23025 7-Carboxy-4-methyl-3,5-dioxoheptanoyl-CoA C23026 5-Carboxy-2-methyl-3-oxopentanoyl-CoA REFERENCE PMID:31284586 AUTHORS Olivera ER, Luengo JM. TITLE Steroids as Environmental Compounds Recalcitrant to Degradation: Genetic Mechanisms of Bacterial Biodegradation Pathways. JOURNAL Genes (Basel) 10:512 (2019) DOI:10.3390/genes10070512 REFERENCE PMID:21056662 AUTHORS Horinouchi M, Hayashi T, Kudo T TITLE Steroid degradation in Comamonas testosteroni. JOURNAL J Steroid Biochem Mol Biol 129:4-14 (2012) DOI:10.1016/j.jsbmb.2010.10.008 REFERENCE PMID:20554032 AUTHORS Horinouchi M, Kurita T, Hayashi T, Kudo T TITLE Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot. JOURNAL J Steroid Biochem Mol Biol 122:253-63 (2010) DOI:10.1016/j.jsbmb.2010.06.002 REFERENCE PMID:34232729 AUTHORS Horinouchi M, Hayashi T. TITLE Identification of the Coenzyme A (CoA) Ester Intermediates and Genes Involved in the Cleavage and Degradation of the Steroidal C-Ring by Comamonas testosteroni TA441. JOURNAL Appl Environ Microbiol 87:e0110221 (2021) DOI:10.1128/AEM.01102-21 REFERENCE PMID:37815361 AUTHORS Horinouchi M, Hayashi T. TITLE Comprehensive summary of steroid metabolism in Comamonas testosteroni TA441: entire degradation process of basic four rings and removal of C12 hydroxyl group. JOURNAL Appl Environ Microbiol 89:e0014323 (2023) DOI:10.1128/aem.00143-23 REFERENCE PMID:21924910 AUTHORS Ouellet H, Johnston JB, de Montellano PR TITLE Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis. JOURNAL Trends Microbiol 19:530-9 (2011) DOI:10.1016/j.tim.2011.07.009 REFERENCE PMID:17264217 AUTHORS Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD TITLE A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. JOURNAL Proc Natl Acad Sci U S A 104:1947-52 (2007) DOI:10.1073/pnas.0605728104 REFERENCE PMID:22045806 AUTHORS Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS TITLE Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism. JOURNAL J Biol Chem 286:43668-78 (2011) DOI:10.1074/jbc.M111.313643 REFERENCE PMID:28377529 AUTHORS Crowe AM, Casabon I, Brown KL, Liu J, Lian J, Rogalski JC, Hurst TE, Snieckus V, Foster LJ, Eltis LD. TITLE Catabolism of the Last Two Steroid Rings in Mycobacterium tuberculosis and Other Bacteria. JOURNAL mBio 8:e00321-17 (2017) DOI:10.1128/mBio.00321-17 REFERENCE PMID:33826843 AUTHORS Yuan T, Werman JM, Yin X, Yang M, Garcia-Diaz M, Sampson NS. TITLE Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA. JOURNAL ACS Infect Dis 7:1739-1751 (2021) DOI:10.1021/acsinfecdis.1c00069 REL_PATHWAY ko00010 Glycolysis / Gluconeogenesis ko00020 Citrate cycle (TCA cycle) ko00100 Steroid biosynthesis ko00140 Steroid hormone biosynthesis ko00640 Propanoate metabolism ///