ENTRY ko00983 Pathway NAME Drug metabolism - other enzymes CLASS Metabolism; Xenobiotics biodegradation and metabolism PATHWAY_MAP ko00983 Drug metabolism - other enzymes ORTHOLOGY K00088 IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205] K00106 XDH; xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2] K00207 DPYD; dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2] K00569 TPMT; thiopurine S-methyltransferase [EC:2.1.1.67] K00622 nat; arylamine N-acetyltransferase [EC:2.3.1.5] K00699 UGT; glucuronosyltransferase [EC:2.4.1.17] K00757 udp, UPP; uridine phosphorylase [EC:2.4.2.3] K00758 deoA, TYMP; thymidine phosphorylase [EC:2.4.2.4] K00760 hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] K00799 GST; glutathione S-transferase [EC:2.5.1.18] K00857 tdk, TK; thymidine kinase [EC:2.7.1.21] K00876 udk, UCK; uridine kinase [EC:2.7.1.48] K00940 ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6] K01044 CES1; carboxylesterase 1 [EC:3.1.1.1] K01195 uidA, GUSB; beta-glucuronidase [EC:3.2.1.31] K01431 UPB1, pydC; beta-ureidopropionase [EC:3.5.1.6] K01464 DPYS, dht, hydA; dihydropyrimidinase [EC:3.5.2.2] K01489 cdd, CDA; cytidine deaminase [EC:3.5.4.5] K01519 rdgB, ITPA; XTP/dITP diphosphohydrolase [EC:3.6.1.66] K01520 dut; dUTP diphosphatase [EC:3.6.1.23] K01951 guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] K03782 katG; catalase-peroxidase [EC:1.11.1.21] K03927 CES2; carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56] K07415 CYP2E1; cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-] K10789 MPO; myeloperoxidase [EC:1.11.2.2] K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] K13421 UMPS; uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23] K13800 CMPK1, UMPK; UMP-CMP kinase [EC:2.7.4.14] K17683 CYP2A6; cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-] K17689 CYP3A4; cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-] K23790 GSTP; glutathione S-transferase P COMPOUND C00003 NAD+ C00006 NADP+ C02320 R-S-Glutathione C02380 6-Mercaptopurine C04242 5-Fluorodeoxyuridine monophosphate C04646 6-Thioinosine-5'-monophosphate C05361 Hydrazine C06108 Fluoroacetate C06837 Azathioprine C07054 Isoniazid C07446 Isonicotinic acid C07447 Acetylhydrazine C07585 N-Acetylisoniazid C07648 Thioguanine C07649 5-FU C11173 SN-38 C11376 SN38 glucuronide C11736 5-Fluorodeoxyuridine C12650 Capecitabine C12673 Tegafur C12739 5'-Deoxy-5-fluorouridine C13252 Carmofur C16542 APC C16543 NPC C16613 6-Thiourate C16614 6-Methylmercaptopurine C16615 6-Methylthiopurine 5'-monophosphate ribonucleotide C16616 6-Mercaptopurine ribonucleoside 5'-diphosphate C16617 6-Mercaptopurine ribonucleoside triphosphate C16618 6-Thioxanthine 5'-monophosphate C16619 6-Thioguanosine monophosphate C16620 6-Methylthioguanosine monophosphate C16621 1-Methyl-4-nitroimidazole C16622 N,N'-Diacetylhydrazine C16623 Isonicotinylglycine C16624 Isoniazid pyruvate C16625 Isoniazid alpha-ketoglutaric acid C16630 5,6-Dihydro-5-fluorouracil C16631 alpha-Fluoro-beta-ureidopropionic acid C16632 alpha-Fluoro-beta-alanine C16633 5-Fluorouridine C16634 5-Fluorouridine monophosphate C16635 5'-Deoxy-5-fluorocytidine C16641 Irinotecan C21748 5-Fluorouridine diphosphate C21749 5-Fluorouridine triphosphate C21750 5-Fluorodeoxyuridine diphosphate C21751 5-Fluorodeoxyuridine triphosphate C21754 Isonicotinoyl radical C21758 Hepatotoxins C21759 Isonicotinoyl-NAD adduct C21760 Isonicotinoyl-NADP adduct D00238 Azathioprine (JP18/USP/INN) D00346 Isoniazid (JP18/USP/INN) D00584 Fluorouracil (JP18/USP/INN) D01223 Capecitabine (JAN/USP/INN) D01244 Tegafur (JP18/USAN/INN) D01309 Doxifluridine (JP18/INN) D01784 Carmofur (JP18/INN) D04197 Floxuridine (USP/INN) D04931 Mercaptopurine (INN) D08086 Irinotecan (INN) D08603 Tioguanine (INN) REFERENCE AUTHORS Kato R, Kamatari T (eds). 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