ENTRY       ko00981                     Pathway
NAME        Insect hormone biosynthesis
CLASS       Metabolism; Metabolism of terpenoids and polyketides
PATHWAY_MAP ko00981  Insect hormone biosynthesis
DBLINKS     GO: 0006718 0006697
ORTHOLOGY   K21013  farnesyl diphosphate phosphatase [EC:3.1.3.-]
            K15890  NADP+-dependent farnesol dehydrogenase [EC:1.1.1.216]
            K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
            K10718  juvenile hormone-III synthase [EC:2.1.1.325]
            K15824  farsoic acid methyltransferase
            K14937  methyl farnesoate epoxidase / farnesoate epoxidase [EC:1.14.14.127 1.14.14.128]
            K10719  juvenile hormone epoxide hydrolase
            K15825  juvenile hormone diol kinase
            K01063  juvenile-hormone esterase [EC:3.1.1.59]
            K15826  sesquiterpenoid omega-hydroxylase
            K14938  cholesterol 7-desaturase [EC:1.14.19.21]
            K14939  cytochrome P450 family 307 subfamily A
            K10720  ecdysteroid 25-hydroxylase [EC:1.14.-.-]
            K10721  ecdysteroid 22-hydroxylase [EC:1.14.-.-]
            K10722  ecdysteroid 2-hydroxylase [EC:1.14.-.-]
            K10723  ecdysone 20-monooxygenase [EC:1.14.99.22]
            K14985  26-hydroxylase [EC:1.14.-.-]
            K10724  ecdysone oxidase [EC:1.1.3.16]
COMPOUND    C00187  Cholesterol
            C00448  trans,trans-Farnesyl diphosphate
            C00477  Ecdysone
            C01126  (2E,6E)-Farnesol
            C01164  7-Dehydrocholesterol
            C02513  3-Dehydroecdysone
            C02633  20-Hydroxyecdysone
            C03461  2-trans,6-trans-Farnesal
            C09694  Juvenile hormone III
            C16493  2,22,25-Trideoxyecdysone
            C16494  2,22-Dideoxyecdysone
            C16495  2-Deoxyecdysone
            C16496  3-Epiecdysone
            C16497  3-Dehydro-2-deoxyecdysone
            C16498  2,22-Dideoxy-3-dehydroecdysone
            C16499  26-Hydroxyecdysone
            C16500  20,26-Dihydroxyecdysone
            C16502  Farnesoic acid
            C16503  Methyl farnesoate
            C16504  Juvenile hormone III acid
            C16505  (10S)-Juvenile hormone III diol
            C16506  (10S)-Juvenile hormone III acid diol
            C16507  (10S)-Juvenile hormone III diol phosphate
            C16508  12-trans-Hydroxy juvenile hormone III
            C16509  14alpha-Hydroxy-5beta-cholest-7-ene-3,6-dione
REFERENCE   PMID:15355237
  AUTHORS   Belles X, Martin D, Piulachs MD.
  TITLE     The mevalonate pathway and the synthesis of juvenile hormone in insects.
  JOURNAL   Annu Rev Entomol 50:181-99 (2005)
            DOI:10.1146/annurev.ento.50.071803.130356
REFERENCE   PMID:15026169
  AUTHORS   Gilbert LI.
  TITLE     Halloween genes encode P450 enzymes that mediate steroid hormone biosynthesis in Drosophila melanogaster.
  JOURNAL   Mol Cell Endocrinol 215:1-10 (2004)
            DOI:10.1016/j.mce.2003.11.003
REFERENCE   PMID:15350618
  AUTHORS   Warren JT, Petryk A, Marques G, Parvy JP, Shinoda T, Itoyama K, Kobayashi J, Jarcho M, Li Y, O'Connor MB, Dauphin-Villemant C, Gilbert LI.
  TITLE     Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis.
  JOURNAL   Insect Biochem Mol Biol 34:991-1010 (2004)
            DOI:10.1016/j.ibmb.2004.06.009
REFERENCE   
  AUTHORS   Omura T, Ishimura Y, Fujii Y (eds).
  TITLE     [Molecular Biology of P450] (In Japanese)
  JOURNAL   Kodansya (2003)
REL_PATHWAY ko00900  Terpenoid backbone biosynthesis
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