ENTRY ko00790 Pathway NAME Folate biosynthesis CLASS Metabolism; Metabolism of cofactors and vitamins PATHWAY_MAP ko00790 Folate biosynthesis MODULE M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00790] M00840 Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF [PATH:ko00790] M00841 Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF [PATH:ko00790] M00842 Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:ko00790] M00843 L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4 [PATH:ko00790] M00880 Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:ko00790] DRUG D00145 Trimethoprim (JAN/USP/INN) D00433 Sulfadiazine, silver (USP) D00447 Sulfamethoxazole (JP18/USP/INN) D00450 Sulfisoxazole (JP18/USP) D00488 Pyrimethamine (JAN/USP/INN) D00580 Sulfadoxine (JAN/USP/INN) D00587 Sulfadiazine (JAN/USP/INN) D00592 Dapsone (USP) D00870 Sulfamethizole (JP18/USP/INN) D00871 Sulfacetamide sodium (USP) D01047 Sulfathiazole (USP/INN) D01141 Sulfamonomethoxine (JAN/USAN/INN) D01142 Sulfadimethoxine (JAN/USP) D01526 Sulfisomidine (JAN) D01601 Acetylsulfamethoxazole (JAN) D01954 Sulfaphenazole (JAN/INN) D02001 Sulfamonomethoxine sodium (JAN) D02387 Cycloguanil pamoate (USAN) D02434 Sulfapyridine (USP/INN) D02435 Sulfamerazine (INN) D02437 Sulfaguanidine (INN) D02439 Sulfamethoxypyridazine (INN) D02440 Phthalylsulfathiazole (INN) D02447 Succinylsulfathiazole D02487 Proguanil hydrochloride (JAN/USP) D02516 Sulfamoxole (USAN/INN) D02519 Sulfacytine (USAN) D02520 Glucosulfone (INN) D03771 Diaveridine (USAN/INN) D05023 Sulfamonomethoxine hydrate (JP18) D05947 Sulfacetamide (USP/INN) D05948 Sulfachlorpyridazine (USP/INN) D05949 Sulfadiazine sodium (USP) D05952 Sulfaquinoxaline (USP/INN) D05956 Sulfisoxazole acetyl (USP) D05957 Sulfisoxazole diolamine (USAN) D06097 Tetroxoprim (USAN/INN) D06236 Trimethoprim sulfate (USP) D07060 Succinylsulfathiazole (INN) D07238 Brodimoprim (INN) D07239 Sulfathiourea (INN) D08337 Iclaprim (USAN/INN) D08428 Proguanil (INN) D08538 Sulfadimethoxine sodium (USP) D08540 Sulfamethoxypyridazine sodium salt D08543 Sulfanilamide (INN) D08563 Iclaprim mesylate (USAN) D08644 Trimethoprim lactate D11085 Trimethoprim hydrochloride DBLINKS GO: 0046656 ORTHOLOGY K01495 GTP cyclohydrolase IA [EC:3.5.4.16] K09007 GTP cyclohydrolase IB [EC:3.5.4.16] K22391 GTP cyclohydrolase I [EC:3.5.4.16] K01077 alkaline phosphatase [EC:3.1.3.1] K01113 alkaline phosphatase D [EC:3.1.3.1] K08310 dihydroneopterin triphosphate diphosphatase [EC:3.6.1.67] K19965 dihydroneopterin triphosphate pyrophosphohydrolase [EC:3.6.1.67] K13939 dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:4.1.2.25 2.7.6.3 2.5.1.15] K13940 dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3] K01633 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] K00950 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] K00796 dihydropteroate synthase [EC:2.5.1.15] K13941 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.7.6.3 2.5.1.15] K24102 dihydrofolate synthase / dihydropteroate synthase [EC:6.3.2.12 2.5.1.15] K18974 dihydropteroate synthase type 1 [EC:2.5.1.15] K18824 dihydropteroate synthase type 2 [EC:2.5.1.15] K18825 dihydropteroate synthase type 3 [EC:2.5.1.15] K00287 dihydrofolate reductase [EC:1.5.1.3] K18589 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K19643 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K18590 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K19644 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K19645 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K18591 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K13998 dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45] K01930 folylpolyglutamate synthase [EC:6.3.2.17] K11754 dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] K22099 dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] K20457 dihydrofolate synthase [EC:6.3.2.12] K01307 gamma-glutamyl hydrolase [EC:3.4.19.9] K01497 GTP cyclohydrolase II [EC:3.5.4.25] K14652 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25] K22100 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase [EC:4.2.1.160] K22101 dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase [EC:4.1.2.60 4.2.3.12] K01664 para-aminobenzoate synthetase component II [EC:2.6.1.85] K01665 para-aminobenzoate synthetase component I [EC:2.6.1.85] K13950 para-aminobenzoate synthetase [EC:2.6.1.85] K03342 para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38] K25575 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) component II [EC:2.6.1.123] K25578 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) component I [EC:2.6.1.123] K02619 4-amino-4-deoxychorismate lyase [EC:4.1.3.38] K18482 4-amino-4-deoxychorismate lyase [EC:4.1.3.38] K07589 D-erythro-7,8-dihydroneopterin triphosphate epimerase [EC:5.1.99.7] K13938 dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.50 1.5.1.3] K01737 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] K00072 sepiapterin reductase [EC:1.1.1.153] K00011 aldehyde reductase [EC:1.1.1.21] K00079 carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197] K04119 aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357] K00357 dihydropteridine reductase [EC:1.5.1.34] K01724 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96] K00500 phenylalanine-4-hydroxylase [EC:1.14.16.1] K00501 tyrosine 3-monooxygenase [EC:1.14.16.2] K00502 tryptophan 5-monooxygenase [EC:1.14.16.4] K03793 pteridine reductase [EC:1.5.1.33] K17745 sepiapterin reductase [EC:1.1.1.325] K00310 pyrimidodiazepine synthase [EC:1.5.4.1] K10026 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3] K06920 7-cyano-7-deazaguanine synthase [EC:6.3.4.20] K06879 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] K09457 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] K17488 GTP cyclohydrolase IV [EC:3.5.4.39] K17487 7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase [EC:3.1.4.56] K09739 dihydroneopterin aldolase [EC:4.1.2.25] K07142 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] K06984 beta-ribofuranosylaminobenzene 5'-phosphate synthase [EC:2.4.2.54] K06897 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase [EC:2.5.1.105] K17364 dihydromethanopterin reductase [EC:1.5.1.47] K18853 dihydromethanopterin reductase (acceptor) [EC:1.5.99.15] K15740 tetrahydromethanopterin:alpha-L-glutamate ligase [EC:6.3.2.33] K22102 dihydroneopterin phosphate aldolase [EC:4.1.2.59] K03639 GTP 3',8-cyclase [EC:4.1.99.22] K03637 cyclic pyranopterin monophosphate synthase [EC:4.6.1.17] K20967 GTP 3',8-cyclase / cyclic pyranopterin monophosphate synthase [EC:4.1.99.22 4.6.1.17] K03635 molybdopterin synthase catalytic subunit [EC:2.8.1.12] K21142 MoaE-MoaD fusion protein [EC:2.8.1.12] K03831 molybdopterin adenylyltransferase [EC:2.7.7.75] K03638 molybdopterin adenylyltransferase [EC:2.7.7.75] K03750 molybdopterin molybdotransferase [EC:2.10.1.1] K15376 gephyrin [EC:2.10.1.1 2.7.7.75] K07141 molybdenum cofactor cytidylyltransferase [EC:2.7.7.76] K03752 molybdenum cofactor guanylyltransferase [EC:2.7.7.77] K13818 molybdopterin-guanine dinucleotide biosynthesis protein [EC:2.7.7.77] K15631 molybdenum cofactor sulfurtransferase [EC:2.8.1.9] COMPOUND C00044 GTP C00101 Tetrahydrofolate C00119 5-Phospho-alpha-D-ribose 1-diphosphate C00156 4-Hydroxybenzoate C00251 Chorismate C00266 Glycolaldehyde C00268 Dihydrobiopterin C00272 Tetrahydrobiopterin C00415 Dihydrofolate C00504 Folate C00568 4-Aminobenzoate C00835 Sepiapterin C00921 Dihydropteroate C01217 5,6,7,8-Tetrahydromethanopterin C01300 6-(Hydroxymethyl)-7,8-dihydropterin C01304 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one C02587 Pyrimidodiazepine C02953 7,8-Dihydrobiopterin C03541 THF-polyglutamate C03684 6-Pyruvoyltetrahydropterin C04244 6-Lactoyl-5,6,7,8-tetrahydropterin C04807 6-Hydroxymethyl-7,8-dihydropterin diphosphate C04874 7,8-Dihydroneopterin C04895 7,8-Dihydroneopterin 3'-triphosphate C05922 Formamidopyrimidine nucleoside triphosphate C05923 2,5-Diaminopyrimidine nucleoside triphosphate C05924 Molybdopterin C05925 Dihydroneopterin phosphate C05926 Neopterin C05927 7,8-Dihydromethanopterin C06148 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine C06313 Biopterin C09332 THF-L-glutamate C11355 4-Amino-4-deoxychorismate C15522 4a-Hydroxytetrahydrobiopterin C15996 7-Cyano-7-carbaguanine C16675 7-Aminomethyl-7-carbaguanine C18237 Molybdoenzyme molybdenum cofactor C18239 Precursor Z C18802 Tetrahydrosarcinapterin C19848 Adenylated molybdopterin C19871 Guanylyl molybdenum cofactor C20239 6-Carboxy-5,6,7,8-tetrahydropterin C20248 7-Carboxy-7-carbaguanine C20264 L-threo-Tetrahydrobiopterin C20559 4-(beta-D-Ribofuranosyl)aniline 5'-phosphate C20562 N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate C20566 7,8-Dihydroneopterin 2'-phosphate C20567 7,8-Dihydroneopterin 2',3'-cyclic phosphate C21007 5,6,7,8-Tetrahydromonapterin C21008 7,8-Dihydromonapterin C21065 7,8-Dihydroxanthopterin C21094 7,8-Dihydromonapterin 3'-triphosphate C21107 4-(beta-D-Ribofuranosyl)phenol 5'-phosphate C21310 (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate C21485 Cytidylyl molybdenum cofactor C21486 Thio-molybdenum cofactor C21640 6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin REFERENCE AUTHORS Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds). TITLE [Cellular Functions and Metabolic Maps] (In Japanese) JOURNAL Tokyo Kagaku Dojin (1997) REFERENCE PMID:19675644 AUTHORS Schwarz G, Mendel RR, Ribbe MW TITLE Molybdenum cofactors, enzymes and pathways. JOURNAL Nature 460:839-47 (2009) DOI:10.1038/nature08302 REFERENCE PMID:16632608 AUTHORS Hanzelmann P, Schindelin H TITLE Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism. JOURNAL Proc Natl Acad Sci U S A 103:6829-34 (2006) DOI:10.1073/pnas.0510711103 REFERENCE PMID:18092812 AUTHORS Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H TITLE Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency. JOURNAL Biochemistry 47:615-26 (2008) DOI:10.1021/bi701734g REFERENCE PMID:12571226 AUTHORS Wuebbens MM, Rajagopalan KV TITLE Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis. JOURNAL J Biol Chem 278:14523-32 (2003) DOI:10.1074/jbc.M300453200 REFERENCE PMID:21867484 AUTHORS Werner ER, Blau N, Thony B TITLE Tetrahydrobiopterin: biochemistry and pathophysiology. JOURNAL Biochem J 438:397-414 (2011) DOI:10.1042/BJ20110293 REFERENCE PMID:12893295 AUTHORS Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A TITLE Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members. JOURNAL Arch Biochem Biophys 416:180-7 (2003) DOI:10.1016/S0003-9861(03)00295-9 REFERENCE PMID:1902669 AUTHORS Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N TITLE Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis. JOURNAL Biochem Biophys Res Commun 175:738-44 (1991) DOI:10.1016/0006-291X(91)91628-P REL_PATHWAY ko00230 Purine metabolism ko00362 Benzoate degradation ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis ko00670 One carbon pool by folate ko00680 Methane metabolism ///