ENTRY ko00770 Pathway NAME Pantothenate and CoA biosynthesis CLASS Metabolism; Metabolism of cofactors and vitamins PATHWAY_MAP ko00770 Pantothenate and CoA biosynthesis MODULE M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ko00770] M00046 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:ko00770] M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate [PATH:ko00770] M00120 Coenzyme A biosynthesis, pantothenate => CoA [PATH:ko00770] M00913 Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate [PATH:ko00770] M00914 Coenzyme A biosynthesis, archaea, 2-oxoisovalerate => 4-phosphopantoate => CoA [PATH:ko00770] DBLINKS GO: 0015940 0015937 ORTHOLOGY K00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86] K00077 panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169] K00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] K00207 DPYD; dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2] K00606 panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] K00826 E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42] K00859 coaE; dephospho-CoA kinase [EC:2.7.1.24] K00867 coaA; type I pantothenate kinase [EC:2.7.1.33] K00954 E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] K00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7] K01431 UPB1, pydC; beta-ureidopropionase [EC:3.5.1.6] K01464 DPYS, dht, hydA; dihydropyrimidinase [EC:3.5.2.2] K01513 ENPP1_3, CD203; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9] K01579 panD; aspartate 1-decarboxylase [EC:4.1.1.11] K01598 PPCDC, coaC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36] K01652 E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] K01653 E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6] K01687 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9] K01918 panC; pantoate--beta-alanine ligase [EC:6.3.2.1] K01922 PPCS, COAB; phosphopantothenate---cysteine ligase (ATP) [EC:6.3.2.51] K01947 birA-coaX; biotin---[acetyl-CoA-carboxylase] ligase / type III pantothenate kinase [EC:6.3.4.15 2.7.1.33] K02201 E2.7.7.3B; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] K02318 COASY; phosphopantetheine adenylyltransferase / dephospho-CoA kinase [EC:2.7.7.3 2.7.1.24] K03525 coaX; type III pantothenate kinase [EC:2.7.1.33] K04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9] K06016 pydC; beta-ureidopropionase / N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87] K06133 LYS5, acpT; 4'-phosphopantetheinyl transferase [EC:2.7.8.-] K06982 pok; pantoate kinase [EC:2.7.1.169] K08069 VNN; pantetheine hydrolase [EC:3.5.1.92] K08682 acpH; acyl carrier protein phosphodiesterase [EC:3.1.4.14] K09680 PANK1_2_3, CAB1, coaW; type II pantothenate kinase [EC:2.7.1.33] K09722 K09722, pps; 4-phosphopantoate---beta-alanine ligase [EC:6.3.2.36] K09735 dpck; GTP-dependent dephospho-CoA kinase [EC:2.7.1.237] K11258 ilvM; acetolactate synthase II small subunit [EC:2.2.1.6] K13038 coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5] K13367 FMS1; polyamine oxidase [EC:1.5.3.17] K13799 panC-cmk; pantoate ligase / CMP/dCMP kinase [EC:6.3.2.1 2.7.4.25] K17722 preT; dihydropyrimidine dehydrogenase (NAD+) subunit PreT [EC:1.3.1.1] K17723 preA; dihydropyrimidine dehydrogenase (NAD+) subunit PreA [EC:1.3.1.1] K17839 PAO4, PAO3, PAO2; polyamine oxidase [EC:1.5.3.17 1.5.3.-] K18933 mfnA, adc; tyrosine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.25 4.1.1.11] K18966 GADL1, CSAD; sulfinoalanine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.29 4.1.1.11] K21977 coaB; phosphopantothenate---cysteine ligase (CTP) [EC:6.3.2.5] K24263 panG; 2-dehydropantoate 2-reductase K24264 panP; aspartate 1-decarboxylase COMPOUND C00010 CoA C00022 Pyruvate C00049 L-Aspartate C00054 Adenosine 3',5'-bisphosphate C00097 L-Cysteine C00099 beta-Alanine C00106 Uracil C00141 3-Methyl-2-oxobutanoic acid C00183 L-Valine C00229 Acyl-carrier protein C00429 5,6-Dihydrouracil C00522 (R)-Pantoate C00750 Spermine C00831 Pantetheine C00864 Pantothenate C00882 Dephospho-CoA C00966 2-Dehydropantoate C01053 (R)-4-Dehydropantoate C01088 (R)-3,3-Dimethylmalate C01134 Pantetheine 4'-phosphate C02642 3-Ureidopropionate C03492 D-4'-Phosphopantothenate C03688 Apo-[acyl-carrier protein] C04079 N-((R)-Pantothenoyl)-L-cysteine C04272 (R)-2,3-Dihydroxy-3-methylbutanoate C04352 (R)-4'-Phosphopantothenoyl-L-cysteine C05665 3-Aminopropanal C05944 Pantothenol C06010 (S)-2-Acetolactate C18911 (R)-4-Phosphopantoate REL_PATHWAY ko00010 Glycolysis / Gluconeogenesis ko00240 Pyrimidine metabolism ko00250 Alanine, aspartate and glutamate metabolism ko00270 Cysteine and methionine metabolism ko00330 Arginine and proline metabolism ko00410 beta-Alanine metabolism ko00640 Propanoate metabolism ///