ENTRY       ko00770                     Pathway
NAME        Pantothenate and CoA biosynthesis
CLASS       Metabolism; Metabolism of cofactors and vitamins
PATHWAY_MAP ko00770  Pantothenate and CoA biosynthesis
MODULE      M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ko00770]
            M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:ko00770]
            M00119  Pantothenate biosynthesis, valine/L-aspartate => pantothenate [PATH:ko00770]
            M00120  Coenzyme A biosynthesis, pantothenate => CoA [PATH:ko00770]
            M00913  Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate [PATH:ko00770]
            M00914  Coenzyme A biosynthesis, archaea, 2-oxoisovalerate => 4-phosphopantoate => CoA [PATH:ko00770]
DBLINKS     GO: 0015940 0015937
ORTHOLOGY   K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
            K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
            K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
            K00053  ketol-acid reductoisomerase [EC:1.1.1.86]
            K01687  dihydroxy-acid dehydratase [EC:4.2.1.9]
            K00606  3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]
            K00077  2-dehydropantoate 2-reductase [EC:1.1.1.169]
            K24263  2-dehydropantoate 2-reductase [EC:1.1.1.169]
            K01918  pantoate--beta-alanine ligase [EC:6.3.2.1]
            K13799  pantoate ligase / CMP/dCMP kinase [EC:6.3.2.1 2.7.4.25]
            K00867  type I pantothenate kinase [EC:2.7.1.33]
            K09680  type II pantothenate kinase [EC:2.7.1.33]
            K03525  type III pantothenate kinase [EC:2.7.1.33]
            K01947  biotin---[acetyl-CoA-carboxylase] ligase / type III pantothenate kinase [EC:6.3.4.15 2.7.1.33]
            K06982  pantoate kinase [EC:2.7.1.169]
            K09722  4-phosphopantoate---beta-alanine ligase [EC:6.3.2.36]
            K01922  phosphopantothenate---cysteine ligase (ATP) [EC:6.3.2.51]
            K21977  phosphopantothenate---cysteine ligase (CTP) [EC:6.3.2.5]
            K01598  phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36]
            K13038  phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5]
            K01513  ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]
            K04765  nucleoside triphosphate diphosphatase [EC:3.6.1.9]
            K02318  phosphopantetheine adenylyltransferase / dephospho-CoA kinase [EC:2.7.7.3 2.7.1.24]
            K00954  pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]
            K02201  pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]
            K00859  dephospho-CoA kinase [EC:2.7.1.24]
            K09735  GTP-dependent dephospho-CoA kinase [EC:2.7.1.237]
            K00997  holo-[acyl-carrier protein] synthase [EC:2.7.8.7]
            K06133  4'-phosphopantetheinyl transferase [EC:2.7.8.-]
            K08682  acyl carrier protein phosphodiesterase [EC:3.1.4.14]
            K08069  pantetheine hydrolase [EC:3.5.1.92]
            K00826  branched-chain amino acid aminotransferase [EC:2.6.1.42]
            K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
            K17722  dihydropyrimidine dehydrogenase (NAD+) subunit PreT [EC:1.3.1.1]
            K17723  dihydropyrimidine dehydrogenase (NAD+) subunit PreA [EC:1.3.1.1]
            K01464  dihydropyrimidinase [EC:3.5.2.2]
            K01431  beta-ureidopropionase [EC:3.5.1.6]
            K06016  beta-ureidopropionase / N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87]
            K01579  aspartate 1-decarboxylase [EC:4.1.1.11]
            K24264  aspartate 1-decarboxylase [EC:4.1.1.11]
            K18933  tyrosine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.25 4.1.1.11]
            K18966  sulfinoalanine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.29 4.1.1.11]
            K17839  polyamine oxidase [EC:1.5.3.17 1.5.3.-]
            K13367  polyamine oxidase [EC:1.5.3.17]
            K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
COMPOUND    C00010  CoA
            C00022  Pyruvate
            C00049  L-Aspartate
            C00054  Adenosine 3',5'-bisphosphate
            C00097  L-Cysteine
            C00099  beta-Alanine
            C00106  Uracil
            C00141  3-Methyl-2-oxobutanoic acid
            C00183  L-Valine
            C00229  Acyl-carrier protein
            C00429  5,6-Dihydrouracil
            C00522  (R)-Pantoate
            C00750  Spermine
            C00831  Pantetheine
            C00864  Pantothenate
            C00882  Dephospho-CoA
            C00966  2-Dehydropantoate
            C01053  (R)-4-Dehydropantoate
            C01088  (R)-3,3-Dimethylmalate
            C01134  Pantetheine 4'-phosphate
            C02642  3-Ureidopropionate
            C03492  D-4'-Phosphopantothenate
            C03688  Apo-[acyl-carrier protein]
            C04079  N-((R)-Pantothenoyl)-L-cysteine
            C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
            C04352  (R)-4'-Phosphopantothenoyl-L-cysteine
            C05665  3-Aminopropanal
            C05944  Pantothenol
            C06010  (S)-2-Acetolactate
            C18911  (R)-4-Phosphopantoate
REL_PATHWAY ko00010  Glycolysis / Gluconeogenesis
            ko00240  Pyrimidine metabolism
            ko00250  Alanine, aspartate and glutamate metabolism
            ko00270  Cysteine and methionine metabolism
            ko00330  Arginine and proline metabolism
            ko00410  beta-Alanine metabolism
            ko00640  Propanoate metabolism
///