ENTRY ko00730 Pathway NAME Thiamine metabolism CLASS Metabolism; Metabolism of cofactors and vitamins PATHWAY_MAP ko00730 Thiamine metabolism MODULE M00127 Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:ko00730] M00895 Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP [PATH:ko00730] M00896 Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:ko00730] M00897 Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP [PATH:ko00730] M00898 Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP [PATH:ko00730] M00899 Thiamine salvage pathway, HMP/HET => TMP [PATH:ko00730] DBLINKS GO: 0006772 ORTHOLOGY K00788 thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] K00877 THI20; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase / thiaminase [EC:2.7.1.49 2.7.4.7 3.5.99.2] K00878 thiM; hydroxyethylthiazole kinase [EC:2.7.1.50] K00939 adk, AK; adenylate kinase [EC:2.7.4.3] K00941 thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7] K00946 thiL; thiamine-monophosphate kinase [EC:2.7.4.16] K00949 thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2] K01077 E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1] K01078 PHO; acid phosphatase [EC:3.1.3.2] K01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7] K03146 THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60] K03147 thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] K03148 thiF; sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73] K03149 thiG; thiazole synthase [EC:2.8.1.10] K03150 thiH; 2-iminoacetate synthase [EC:4.1.99.19] K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] K03153 thiO; glycine oxidase [EC:1.4.3.19] K03707 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2] K04487 iscS, NFS1; cysteine desulfurase [EC:2.8.1.7] K05307 THTPA; thiamine-triphosphatase [EC:3.6.1.28] K06928 NTPCR; nucleoside-triphosphatase [EC:3.6.1.15] K06949 rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] K07251 thiK; thiamine kinase [EC:2.7.1.89] K10810 tenI; thiazole tautomerase (transcriptional regulator TenI) [EC:5.3.99.10] K10811 E2.5.1.2; thiamine pyridinylase [EC:2.5.1.2] K14153 thiDE; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3] K14154 THI6; thiamine-phosphate diphosphorylase / hydroxyethylthiazole kinase [EC:2.5.1.3 2.7.1.50] K14394 ACP1; low molecular weight phosphotyrosine protein phosphatase [EC:3.1.3.2 3.1.3.48] K18278 THI5; pyrimidine precursor biosynthesis enzyme K20895 ylmB; formylaminopyrimidine deformylase [EC:3.5.1.-] K20896 TENA_E; formylaminopyrimidine deformylase / aminopyrimidine aminohydrolase [EC:3.5.1.- 3.5.99.-] K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3] K21220 thiN; thiamine-phosphate diphosphorylase [EC:2.5.1.3] K22699 thi4; sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] K22911 TH2; thiamine phosphate phosphatase / amino-HMP aminohydrolase [EC:3.1.3.100 3.5.99.-] K23458 PHO5_11_12; repressible acid phosphatase COMPOUND C00003 NAD+ C00018 Pyridoxal phosphate C00022 Pyruvate C00037 Glycine C00068 Thiamin diphosphate C00082 L-Tyrosine C00097 L-Cysteine C00118 D-Glyceraldehyde 3-phosphate C00378 Thiamine C01081 Thiamin monophosphate C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine C02892 Thiamine acetic acid C03028 Thiamin triphosphate C03373 Aminoimidazole ribotide C04294 5-(2-Hydroxyethyl)-4-methylthiazole C04327 4-Methyl-5-(2-phosphooxyethyl)thiazole C04556 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine C04752 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate C05856 Thiamine aldehyde C11437 1-Deoxy-D-xylulose 5-phosphate C15809 Iminoglycine C15810 Sulfur-carrier protein C15811 [Enzyme]-cysteine C15812 [Enzyme]-S-sulfanylcysteine C15813 Adenylyl-[sulfur-carrier protein] C15814 Thiocarboxy-[sulfur-carrier protein] C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine C20246 2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate C20247 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate C20267 4-Amino-5-aminomethyl-2-methylpyrimidine C20784 ADP-5-ethyl-4-methylthiazole-2-carboxylate REFERENCE PMID:15614489 AUTHORS Kawasaki Y, Onozuka M, Mizote T, Nosaka K. TITLE Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae. JOURNAL Curr Genet 47:156-62 (2005) DOI:10.1007/s00294-004-0557-x REFERENCE PMID:14567704 AUTHORS Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP. TITLE Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). JOURNAL Biochemistry 42:12430-8 (2003) DOI:10.1021/bi034902z REFERENCE PMID:22616866 AUTHORS Begley TP, Ealick SE, McLafferty FW TITLE Thiamin biosynthesis: still yielding fascinating biological chemistry. JOURNAL Biochem Soc Trans 40:555-60 (2012) DOI:10.1042/BST20120084 REFERENCE PMID:12777485 AUTHORS Wightman R, Meacock PA TITLE The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. JOURNAL Microbiology 149:1447-60 (2003) DOI:10.1099/mic.0.26194-0 REFERENCE PMID:22031445 AUTHORS Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP TITLE Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. JOURNAL Nature 478:542-6 (2011) DOI:10.1038/nature10503 REFERENCE PMID:19348578 AUTHORS Jurgenson CT, Begley TP, Ealick SE TITLE The structural and biochemical foundations of thiamin biosynthesis. JOURNAL Annu Rev Biochem 78:569-603 (2009) DOI:10.1146/annurev.biochem.78.072407.102340 REL_PATHWAY ko00010 Glycolysis / Gluconeogenesis ko00230 Purine metabolism ko00260 Glycine, serine and threonine metabolism ko00270 Cysteine and methionine metabolism ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis ko00750 Vitamin B6 metabolism ///