ENTRY       ko00670                     Pathway
NAME        One carbon pool by folate
CLASS       Metabolism; Metabolism of cofactors and vitamins
PATHWAY_MAP ko00670  One carbon pool by folate
MODULE      M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00670]
            M00140  C1-unit interconversion, prokaryotes [PATH:ko00670]
            M00141  C1-unit interconversion, eukaryotes [PATH:ko00670]
DRUG        D00145  Trimethoprim (JAN/USP/INN)
            D00488  Pyrimethamine (JAN/USP/INN)
            D02387  Cycloguanil pamoate (USAN)
            D02487  Proguanil hydrochloride (JAN/USP)
            D03771  Diaveridine (USAN/INN)
            D06097  Tetroxoprim (USAN/INN)
            D06236  Trimethoprim sulfate (USP)
            D07238  Brodimoprim (INN)
            D08337  Iclaprim (USAN/INN)
            D08428  Proguanil (INN)
            D08563  Iclaprim mesylate (USAN)
            D08644  Trimethoprim lactate
            D11085  Trimethoprim hydrochloride
DBLINKS     GO: 0035999
ORTHOLOGY   K00287  dihydrofolate reductase [EC:1.5.1.3]
            K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
            K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
            K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
            K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
            K19645  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
            K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
            K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
            K13938  dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.50 1.5.1.3]
            K01938  formate--tetrahydrofolate ligase [EC:6.3.4.3]
            K13402  monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3]
            K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
            K01491  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
            K01500  methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9]
            K00300  methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+) [EC:1.5.1.5 1.5.1.-]
            K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
            K00295  methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15]
            K00600  glycine hydroxymethyltransferase [EC:2.1.2.1]
            K11787  phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]
            K00601  phosphoribosylglycinamide formyltransferase [EC:2.1.2.2]
            K11175  phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
            K01492  phosphoribosylglycinamide/phosphoribosylaminoimidazolecarboxamide formyltransferase [EC:2.1.2.2 2.1.2.3]
            K00602  phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
            K00603  glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2]
            K13990  glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4]
            K00604  methionyl-tRNA formyltransferase [EC:2.1.2.9]
            K00605  glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]
            K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
            K24042  methionine synthase / methylenetetrahydrofolate reductase (NADH) [EC:2.1.1.13 1.5.1.54]
            K25221  [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.378]
            K25915  [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.385]
            K26930  [methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.389]
            K00560  thymidylate synthase [EC:2.1.1.45]
            K03465  thymidylate synthase (FAD) [EC:2.1.1.148]
            K00289  formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]
            K01433  formyltetrahydrofolate deformylase [EC:3.5.1.10]
            K25009  methylenetetrahydrofolate reductase [NAD(P)H] [EC:1.5.1.20]
            K25004  methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.53]
            K00297  methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]
            K25007  methylenetetrahydrofolate reductase (NADH) small subunit
            K25008  ion-translocating oxidoreductase complex subunit C [EC:7.-.-.-]
            K01746  formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]
            K01934  5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]
COMPOUND    C00101  Tetrahydrofolate
            C00143  5,10-Methylenetetrahydrofolate
            C00234  10-Formyltetrahydrofolate
            C00415  Dihydrofolate
            C00440  5-Methyltetrahydrofolate
            C00445  5,10-Methenyltetrahydrofolate
            C00504  Folate
            C00664  5-Formiminotetrahydrofolate
            C03479  Folinic acid
REL_PATHWAY ko00790  Folate biosynthesis
///