ENTRY ko00670 Pathway NAME One carbon pool by folate CLASS Metabolism; Metabolism of cofactors and vitamins PATHWAY_MAP ko00670 One carbon pool by folate MODULE M00035 Methionine degradation [PATH:ko00670] M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00670] M00140 C1-unit interconversion, prokaryotes [PATH:ko00670] M00141 C1-unit interconversion, eukaryotes [PATH:ko00670] M00338 Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ko00670] M00555 Betaine biosynthesis, choline => betaine [PATH:ko00670] M00621 Glycine cleavage system [PATH:ko00670] M00974 Betaine metabolism, animals, betaine => glycine [PATH:ko00670] DRUG D00145 Trimethoprim (JAN/USP/INN) D00488 Pyrimethamine (JAN/USP/INN) D02387 Cycloguanil pamoate (USAN) D02487 Proguanil hydrochloride (JAN/USP) D03771 Diaveridine (USAN/INN) D06097 Tetroxoprim (USAN/INN) D06236 Trimethoprim sulfate (USP) D07238 Brodimoprim (INN) D08337 Iclaprim (USAN/INN) D08428 Proguanil (INN) D08563 Iclaprim mesylate (USAN) D08644 Trimethoprim lactate D11085 Trimethoprim hydrochloride DBLINKS GO: 0035999 ORTHOLOGY K00108 betA, CHDH; choline dehydrogenase [EC:1.1.99.1] K00130 betB, gbsA; betaine-aldehyde dehydrogenase [EC:1.2.1.8] K00281 GLDC, gcvP; glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2] K00282 gcvPA; glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2] K00283 gcvPB; glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2] K00287 DHFR, folA; dihydrofolate reductase [EC:1.5.1.3] K00288 MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3] K00289 ALDH1L; formyltetrahydrofolate dehydrogenase [EC:1.5.1.6] K00295 MTD1; methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15] K00297 metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54] K00300 mtdA; methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+) K00309 dmg; dimethylglycine oxidase K00314 SARDH; sarcosine dehydrogenase [EC:1.5.8.3] K00315 DMGDH; dimethylglycine dehydrogenase [EC:1.5.8.4] K00382 DLD, lpd, pdhD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] K00499 CMO; choline monooxygenase [EC:1.14.15.7] K00544 BHMT; betaine-homocysteine S-methyltransferase [EC:2.1.1.5] K00547 mmuM, BHMT2; homocysteine S-methyltransferase [EC:2.1.1.10] K00548 metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] K00552 GNMT; glycine N-methyltransferase [EC:2.1.1.20] K00560 thyA, TYMS; thymidylate synthase [EC:2.1.1.45] K00600 glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1] K00601 E2.1.2.2; phosphoribosylglycinamide formyltransferase [EC:2.1.2.2] K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] K00603 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] K00605 gcvT, AMT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10] K00789 metK, MAT; S-adenosylmethionine synthetase [EC:2.5.1.6] K01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1] K01433 purU; formyltetrahydrofolate deformylase [EC:3.5.1.10] K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] K01492 purNH; phosphoribosylglycinamide/phosphoribosylaminoimidazolecarboxamide formyltransferase [EC:2.1.2.2 2.1.2.3] K01500 fchA; methenyltetrahydrofolate cyclohydrolase K01697 CBS; cystathionine beta-synthase [EC:4.2.1.22] K01746 E4.3.1.4; formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4] K01758 CTH; cystathionine gamma-lyase [EC:4.4.1.1] K01934 MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3] K02437 gcvH, GCSH; glycine cleavage system H protein K03465 thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] K10150 cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22] K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] K11440 gbsB; choline dehydrogenase [EC:1.1.1.1] K11787 GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1] K13402 MTHFD1L; monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3] K13403 MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9] K13938 folM; dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.50 1.5.1.3] K13990 FTCD; glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4] K13998 DHFR-TS; dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45] K14085 ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] K17217 mccB; cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2] K17755 codA; choline oxidase [EC:1.1.3.17] K18589 dfrA1, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K18590 dfrA12, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K18591 dfrD, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K19643 dfrA10, dfr10; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K19644 dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K24042 yitJ; methionine synthase / methylenetetrahydrofolate reductase (NADH) K25004 MTHFR; methylenetetrahydrofolate reductase (NADPH) K25007 metV; methylenetetrahydrofolate reductase (NADH) small subunit K25008 rnfC2; ion-translocating oxidoreductase complex subunit C K25009 E1.5.1.20; methylenetetrahydrofolate reductase [NAD(P)H] K25221 mtgA; [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase K25915 mtvA; [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase K26930 mtqA; [methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase COMPOUND C00002 ATP C00019 S-Adenosyl-L-methionine C00021 S-Adenosyl-L-homocysteine C00037 Glycine C00065 L-Serine C00073 L-Methionine C00097 L-Cysteine C00101 Tetrahydrofolate C00114 Choline C00143 5,10-Methylenetetrahydrofolate C00155 L-Homocysteine C00212 Adenosine C00213 Sarcosine C00234 10-Formyltetrahydrofolate C00364 dTMP C00365 dUMP C00415 Dihydrofolate C00440 5-Methyltetrahydrofolate C00445 5,10-Methenyltetrahydrofolate C00504 Folate C00576 Betaine aldehyde C00664 5-Formiminotetrahydrofolate C00719 Betaine C01026 N,N-Dimethylglycine C02291 L-Cystathionine C03479 Folinic acid REL_PATHWAY ko00260 Glycine, serine and threonine metabolism ko00270 Cysteine and methionine metabolism ko00790 Folate biosynthesis ///