ENTRY ko00670 Pathway NAME One carbon pool by folate CLASS Metabolism; Metabolism of cofactors and vitamins PATHWAY_MAP ko00670 One carbon pool by folate MODULE M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00670] M00140 C1-unit interconversion, prokaryotes [PATH:ko00670] M00141 C1-unit interconversion, eukaryotes [PATH:ko00670] DRUG D00145 Trimethoprim (JAN/USP/INN) D00488 Pyrimethamine (JAN/USP/INN) D02387 Cycloguanil pamoate (USAN) D02487 Proguanil hydrochloride (JAN/USP) D03771 Diaveridine (USAN/INN) D06097 Tetroxoprim (USAN/INN) D06236 Trimethoprim sulfate (USP) D07238 Brodimoprim (INN) D08337 Iclaprim (USAN/INN) D08428 Proguanil (INN) D08563 Iclaprim mesylate (USAN) D08644 Trimethoprim lactate D11085 Trimethoprim hydrochloride DBLINKS GO: 0035999 ORTHOLOGY K00287 dihydrofolate reductase [EC:1.5.1.3] K18589 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K19643 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K18590 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K19644 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K19645 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K18591 dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] K13998 dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45] K13938 dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.50 1.5.1.3] K01938 formate--tetrahydrofolate ligase [EC:6.3.4.3] K13402 monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3] K00288 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3] K01491 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] K01500 methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9] K00300 methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+) [EC:1.5.1.5 1.5.1.-] K13403 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9] K00295 methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15] K00600 glycine hydroxymethyltransferase [EC:2.1.2.1] K11787 phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1] K00601 phosphoribosylglycinamide formyltransferase [EC:2.1.2.2] K11175 phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] K01492 phosphoribosylglycinamide/phosphoribosylaminoimidazolecarboxamide formyltransferase [EC:2.1.2.2 2.1.2.3] K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] K00603 glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] K13990 glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4] K00605 glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10] K00548 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] K24042 methionine synthase / methylenetetrahydrofolate reductase (NADH) [EC:2.1.1.13 1.5.1.54] K25221 [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.378] K25915 [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.385] K26930 [methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.389] K00560 thymidylate synthase [EC:2.1.1.45] K03465 thymidylate synthase (FAD) [EC:2.1.1.148] K00289 formyltetrahydrofolate dehydrogenase [EC:1.5.1.6] K01433 formyltetrahydrofolate deformylase [EC:3.5.1.10] K25009 methylenetetrahydrofolate reductase [NAD(P)H] [EC:1.5.1.20] K25004 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.53] K00297 methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54] K25007 methylenetetrahydrofolate reductase (NADH) small subunit K25008 ion-translocating oxidoreductase complex subunit C [EC:7.-.-.-] K01746 formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4] K01934 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] K00547 homocysteine S-methyltransferase [EC:2.1.1.10] K00544 betaine-homocysteine S-methyltransferase [EC:2.1.1.5] K00789 S-adenosylmethionine synthetase [EC:2.5.1.6] K00552 glycine N-methyltransferase [EC:2.1.1.20] K01251 adenosylhomocysteinase [EC:3.13.2.1] K00315 dimethylglycine dehydrogenase [EC:1.5.8.4] K00309 dimethylglycine oxidase [EC:1.5.3.10] K00314 sarcosine dehydrogenase [EC:1.5.8.3] K00281 glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2] K00282 glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2] K00283 glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2] K00382 dihydrolipoyl dehydrogenase [EC:1.8.1.4] K02437 glycine cleavage system H protein K00108 choline dehydrogenase [EC:1.1.99.1] K00499 choline monooxygenase [EC:1.14.15.7] K11440 choline dehydrogenase [EC:1.1.1.1] K17755 choline oxidase [EC:1.1.3.17] K00130 betaine-aldehyde dehydrogenase [EC:1.2.1.8] K14085 aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] K01697 cystathionine beta-synthase [EC:4.2.1.22] K10150 cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22] K01758 cystathionine gamma-lyase [EC:4.4.1.1] K17217 cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2] COMPOUND C00002 ATP C00019 S-Adenosyl-L-methionine C00021 S-Adenosyl-L-homocysteine C00037 Glycine C00065 L-Serine C00073 L-Methionine C00097 L-Cysteine C00101 Tetrahydrofolate C00114 Choline C00143 5,10-Methylenetetrahydrofolate C00155 L-Homocysteine C00212 Adenosine C00213 Sarcosine C00234 10-Formyltetrahydrofolate C00364 dTMP C00365 dUMP C00415 Dihydrofolate C00440 5-Methyltetrahydrofolate C00445 5,10-Methenyltetrahydrofolate C00504 Folate C00576 Betaine aldehyde C00664 5-Formiminotetrahydrofolate C00719 Betaine C01026 N,N-Dimethylglycine C02291 L-Cystathionine C03479 Folinic acid REL_PATHWAY ko00260 Glycine, serine and threonine metabolism ko00270 Cysteine and methionine metabolism ko00790 Folate biosynthesis ///