ENTRY ko00633 Pathway NAME Nitrotoluene degradation CLASS Metabolism; Xenobiotics biodegradation and metabolism PATHWAY_MAP ko00633 Nitrotoluene degradation DBLINKS UMBBD: tnt tnt2 dnt GO: 0046260 ORTHOLOGY K10678 nitroreductase [EC:1.-.-.-] K10679 nitroreductase / dihydropteridine reductase [EC:1.-.-.- 1.5.1.34] K10680 N-ethylmaleimide reductase [EC:1.-.-.-] K06281 hydrogenase large subunit [EC:1.12.99.6] K06282 hydrogenase small subunit [EC:1.12.99.6] K23549 uptake hydrogenase large subunit [EC:1.12.99.6] K23548 uptake hydrogenase small subunit [EC:1.12.99.6] K00198 anaerobic carbon-monoxide dehydrogenase catalytic subunit [EC:1.2.7.4] K00196 anaerobic carbon-monoxide dehydrogenase iron sulfur subunit K00169 pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1] K00170 pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1] K00172 pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1] K00189 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1] K00171 pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1] K11180 dissimilatory sulfite reductase alpha subunit [EC:1.8.1.22] K11181 dissimilatory sulfite reductase beta subunit [EC:1.8.1.22] K27196 dissimilatory sulfite reductase flavoprotein subunit K00622 arylamine N-acetyltransferase [EC:2.3.1.5] K14579 naphthalene 1,2-dioxygenase subunit alpha [EC:1.14.12.12 1.14.12.23 1.14.12.24] K14580 naphthalene 1,2-dioxygenase subunit beta [EC:1.14.12.12 1.14.12.23 1.14.12.24] K14578 naphthalene 1,2-dioxygenase ferredoxin component K14581 naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7] K21683 4-methyl-5-nitrocatechol 5-monooxygenase [EC:1.14.13.210] COMPOUND C01468 4-Cresol C06002 (S)-Methylmalonate semialdehyde C11006 2,4-Dinitrotoluene C14401 2,4-Diaminotoluene C16391 Trinitrotoluene C16392 4-Hydroxylamino-2,6-dinitrotoluene C16393 2-Hydroxylamino-4,6-dinitrotoluene C16394 4-Amino-2,6-dinitrotoluene C16395 2-Amino-4,6-dinitrotoluene C16396 2,4-Diamino-6-nitrotoluene C16397 2,6-Diamino-4-nitrotoluene C16398 2-Amino-4-nitrotoluene C16399 2,4-Diamino-6-hydroxylaminotoluene C16400 2,4,6-Triaminotoluene C16401 2,4,6-Trihydroxytoluene C16402 2,4-Dihydroxylamino-6-nitrotoluene C16403 4-Amino-2-hydroxylamino-6-nitrotoluene C16411 4,4',6,6'-Tetranitro-2,2'-azoxytoluene C16412 2,4',6,6'-Tetranitro-2',4-azoxytoluene C16413 2,2',6,6'-Tetranitro-4,4'-azoxytoluene C16414 2-Amino-5-hydroxyl-4-hydroxylamino-6-nitrotoluene C16420 4-Acetamido-2-amino-6-nitrotoluene C18315 4-Methyl-5-nitrocatechol C18316 2-Hydroxy-5-methylquinone C18317 2,4,5-Trihydroxytoluene C18318 cis,cis-2,4-Dihydroxy-5-methyl-6-oxo-2,4-hexadienoate C18320 4-Amino-2-nitrotoluene REFERENCE AUTHORS Esteve-Nunez A, Ramos JL. TITLE Metabolism of 2,4,6-trinitrotoluene by Pseudomonas sp. JLR11. JOURNAL Environ Sci Tech 32:3802-3808 (1998) DOI:10.1021/es9803308 REFERENCE PMID:8534088 AUTHORS Gilcrease PC, Murphy VG. TITLE Bioconversion of 2,4-diamino-6-nitrotoluene to a novel metabolite under anoxic and aerobic conditions. JOURNAL Appl Environ Microbiol 61:4209-14 (1995) DOI:10.1128/AEM.61.12.4209-4214.1995 REFERENCE PMID:11527999 AUTHORS Esteve-Nunez A, Caballero A, Ramos JL. TITLE Biological degradation of 2,4,6-trinitrotoluene. JOURNAL Microbiol Mol Biol Rev 65:335-52, table of contents (2001) DOI:10.1128/MMBR.65.3.335-352.2001 REFERENCE PMID:14751225 AUTHORS Fleischmann TJ, Walker KC, Spain JC, Hughes JB, Morrie Craig A. TITLE Anaerobic transformation of 2,4,6-TNT by bovine ruminal microbes. JOURNAL Biochem Biophys Res Commun 314:957-63 (2004) DOI:10.1016/j.bbrc.2003.12.193 REFERENCE PMID:14753774 AUTHORS Borch T, Gerlach R. TITLE Use of reversed-phase high-performance liquid chromatography-diode array detection for complete separation of 2,4,6-trinitrotoluene metabolites and EPA Method 8330 explosives: influence of temperature and an ion-pair reagent. JOURNAL J Chromatogr A 1022:83-94 (2004) DOI:10.1016/j.chroma.2003.09.067 REFERENCE PMID:15490158 AUTHORS Yin H, Wood TK, Smets BF. TITLE Reductive transformation of TNT by Escherichia coli: pathway description. JOURNAL Appl Microbiol Biotechnol 67:397-404 (2005) DOI:10.1007/s00253-004-1736-x REFERENCE PMID:16187099 AUTHORS Kutty R, Bennett GN. TITLE Biochemical characterization of trinitrotoluene transforming oxygen-insensitive nitroreductases from Clostridium acetobutylicum ATCC 824. JOURNAL Arch Microbiol 184:158-67 (2005) DOI:10.1007/s00203-005-0036-x REFERENCE PMID:16535610 AUTHORS Fiorella PD, Spain JC. TITLE Transformation of 2,4,6-Trinitrotoluene by Pseudomonas pseudoalcaligenes JS52. JOURNAL Appl Environ Microbiol 63:2007-2015 (1997) DOI:10.1128/AEM.63.5.2007-2015.1997 REFERENCE PMID:17504490 AUTHORS Gonzalez-Perez MM, van Dillewijn P, Wittich RM, Ramos JL. TITLE Escherichia coli has multiple enzymes that attack TNT and release nitrogen for growth. JOURNAL Environ Microbiol 9:1535-40 (2007) DOI:10.1111/j.1462-2920.2007.01272.x REFERENCE PMID:16535348 AUTHORS Noguera DR, Freedman DL TITLE Reduction and Acetylation of 2,4-Dinitrotoluene by a Pseudomonas aeruginosa Strain. JOURNAL Appl Environ Microbiol 62:2257-63 (1996) DOI:10.1128/AEM.62.7.2257-2263.1996 REFERENCE PMID:9922262 AUTHORS Haigler BE, Johnson GR, Suen WC, Spain JC TITLE Biochemical and genetic evidence for meta-ring cleavage of 2,4, 5-trihydroxytoluene in Burkholderia sp. strain DNT. JOURNAL J Bacteriol 181:965-72 (1999) DOI:10.1128/JB.181.3.965-972.1999 REFERENCE PMID:12107140 AUTHORS Johnson GR, Jain RK, Spain JC TITLE Origins of the 2,4-dinitrotoluene pathway. JOURNAL J Bacteriol 184:4219-32 (2002) DOI:10.1128/JB.184.15.4219-4232.2002 REL_PATHWAY ko00280 Valine, leucine and isoleucine degradation ko00623 Toluene degradation ///