ENTRY ko00630 Pathway NAME Glyoxylate and dicarboxylate metabolism CLASS Metabolism; Carbohydrate metabolism PATHWAY_MAP ko00630 Glyoxylate and dicarboxylate metabolism MODULE M00012 Glyoxylate cycle [PATH:ko00630] M00373 Ethylmalonyl pathway [PATH:ko00630] M00532 Photorespiration [PATH:ko00630] M00621 Glycine cleavage system [PATH:ko00630] M00740 Methylaspartate cycle [PATH:ko00630] M00741 Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:ko00630] M00968 Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate [PATH:ko00630] DBLINKS GO: 0046487 0043648 ORTHOLOGY K01637 isocitrate/methylisocitrate lyase [EC:4.1.3.1 4.1.3.30] K01895 acetyl-CoA synthetase [EC:6.2.1.1] K01913 acetate/butyrate---CoA ligase [EC:6.2.1.1 6.2.1.2] K01638 malate synthase [EC:2.3.3.9] K00025 malate dehydrogenase [EC:1.1.1.37] K00026 malate dehydrogenase [EC:1.1.1.37] K00024 malate dehydrogenase [EC:1.1.1.37] K01647 citrate synthase [EC:2.3.3.1] K01659 2-methylcitrate synthase [EC:2.3.3.5] K27797 2-methylcitrate synthase [EC:2.3.3.5] K01681 aconitate hydratase [EC:4.2.1.3] K27802 aconitate hydratase A / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99] K01682 aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99] K08692 malate-CoA ligase subunit alpha [EC:6.2.1.9] K14067 malate-CoA ligase subunit beta [EC:6.2.1.9] K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] K00023 acetoacetyl-CoA reductase [EC:1.1.1.36] K17865 3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55] K14446 crotonyl-CoA carboxylase/reductase [EC:1.3.1.85] K05606 methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] K14447 ethylmalonyl-CoA mutase [EC:5.4.99.63] K14448 (2S)-methylsuccinyl-CoA dehydrogenase [EC:1.3.8.12] K14449 2-methylfumaryl-CoA hydratase [EC:4.2.1.148] K08691 malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25] K14451 (3S)-malyl-CoA thioesterase [EC:3.1.2.30] K01965 propionyl-CoA carboxylase alpha subunit [EC:6.4.1.3] K01966 propionyl-CoA carboxylase beta subunit [EC:6.4.1.3 2.1.3.15] K11263 acetyl-CoA/propionyl-CoA/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14] K27094 propionyl-CoA/long-chain acyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.3 6.4.1.- 2.1.3.15] K27095 acyl-CoA carboxylase epsilon subunit K18472 acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] K19312 acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] K22568 acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3] K01964 acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] K15036 acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15] K15037 biotin carboxyl carrier protein K01847 methylmalonyl-CoA mutase [EC:5.4.99.2] K01849 methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2] K01848 methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2] K19268 methylaspartate mutase epsilon subunit [EC:5.4.99.1] K01846 methylaspartate mutase sigma subunit [EC:5.4.99.1] K04835 methylaspartate ammonia-lyase [EC:4.3.1.2] K19280 succinyl-CoA:mesaconate CoA transferase [EC:2.8.3.26] K19281 beta-methylmalyl-CoA/(S)-malyl-CoA lyase [EC:4.1.3.24] K19282 bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30] K00104 glycolate dehydrogenase FAD-linked subunit [EC:1.1.99.14] K11472 glycolate dehydrogenase FAD-binding subunit [EC:1.1.99.14] K11473 glycolate dehydrogenase iron-sulfur subunit [EC:1.1.99.14] K11517 (S)-2-hydroxy-acid oxidase [EC:1.1.3.15] K03781 catalase [EC:1.11.1.6] K00015 glyoxylate reductase [EC:1.1.1.26] K00049 glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81] K15919 glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81] K18121 glyoxylate/succinic semialdehyde reductase [EC:1.1.1.79 1.1.1.-] K12972 glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81] K00090 glyoxylate/hydroxypyruvate/2-ketogluconate reductase [EC:1.1.1.79 1.1.1.81 1.1.1.215] K00018 glycerate dehydrogenase [EC:1.1.1.29] K15893 glycerate dehydrogenase [EC:1.1.1.29] K22982 hydroxypyruvate reductase [EC:1.1.1.81] K19269 phosphoglycolate phosphatase [EC:3.1.3.18 3.1.3.48] K01091 phosphoglycolate phosphatase [EC:3.1.3.18] K22223 phosphoglycolate phosphatase [EC:3.1.3.18] K01601 ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39] K01602 ribulose-bisphosphate carboxylase small chain [EC:4.1.1.39] K00830 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase [EC:2.6.1.44 2.6.1.45 2.6.1.51] K14272 glutamate--glyoxylate aminotransferase [EC:2.6.1.4 2.6.1.2 2.6.1.44] K00284 glutamate synthase (ferredoxin) [EC:1.4.7.1] K01915 glutamine synthetase [EC:6.3.1.2] K00600 glycine hydroxymethyltransferase [EC:2.1.2.1] K00281 glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2] K00282 glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2] K00283 glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2] K00605 glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10] K00382 dihydrolipoyl dehydrogenase [EC:1.8.1.4] K02437 glycine cleavage system H protein K01608 tartronate-semialdehyde synthase [EC:4.1.1.47] K01816 hydroxypyruvate isomerase [EC:5.3.1.22] K00042 2-hydroxy-3-oxopropionate reductase [EC:1.1.1.60] K00865 glycerate 2-kinase [EC:2.7.1.165] K11529 glycerate 2-kinase [EC:2.7.1.165] K15918 D-glycerate 3-kinase [EC:2.7.1.31] K07248 lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase [EC:1.2.1.22 1.2.1.21] K00048 lactaldehyde reductase [EC:1.1.1.77] K26209 glycolaldehyde reductase [EC:1.1.1.-] K26210 ribulose-1,5-bisphosphate 5-phosphatase [EC:3.1.3.109] K01636 ribulose 1-phosphate aldolase [EC:4.1.2.-] K03779 L(+)-tartrate dehydratase alpha subunit [EC:4.2.1.32] K03780 L(+)-tartrate dehydratase beta subunit [EC:4.2.1.32] K07246 tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase [EC:1.1.1.93 4.1.1.73 1.1.1.83] K01625 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] K18123 4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16] K01616 multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61] K01569 oxalate decarboxylase [EC:4.1.1.2] K00122 formate dehydrogenase [EC:1.17.1.9] K00126 formate dehydrogenase subunit delta [EC:1.17.1.9] K00123 formate dehydrogenase major subunit [EC:1.17.1.9] K22515 formate dehydrogenase beta subunit [EC:1.17.1.9] K00124 formate dehydrogenase iron-sulfur subunit K00127 formate dehydrogenase subunit gamma K01432 arylformamidase [EC:3.5.1.9] K14263 kynurenine formamidase [EC:3.5.1.9] K07130 arylformamidase [EC:3.5.1.9] K01433 formyltetrahydrofolate deformylase [EC:3.5.1.10] K01455 formamidase [EC:3.5.1.49] K25305 N,N-dimethylformamidase small subunit [EC:3.5.1.56] K03418 N,N-dimethylformamidase large subunit [EC:3.5.1.56] K01458 N-formylglutamate deformylase [EC:3.5.1.68] K22133 oxalate---CoA ligase [EC:6.2.1.8] K01577 oxalyl-CoA decarboxylase [EC:4.1.1.8] K07749 formyl-CoA transferase [EC:2.8.3.16] COMPOUND C00007 Oxygen C00011 CO2 C00014 Ammonia C00022 Pyruvate C00024 Acetyl-CoA C00025 L-Glutamate C00026 2-Oxoglutarate C00027 Hydrogen peroxide C00033 Acetate C00036 Oxaloacetate C00037 Glycine C00042 Succinate C00048 Glyoxylate C00058 Formate C00064 L-Glutamine C00065 L-Serine C00091 Succinyl-CoA C00100 Propanoyl-CoA C00111 Glycerone phosphate C00136 Butanoyl-CoA C00149 (S)-Malate C00158 Citrate C00160 Glycolate C00168 Hydroxypyruvate C00197 3-Phospho-D-glycerate C00209 Oxalate C00258 D-Glycerate C00266 Glycolaldehyde C00311 Isocitrate C00313 Oxalyl-CoA C00332 Acetoacetyl-CoA C00417 cis-Aconitate C00552 meso-Tartaric acid C00631 2-Phospho-D-glycerate C00683 (S)-Methylmalonyl-CoA C00798 Formyl-CoA C00877 Crotonoyl-CoA C00888 Pentanoyl-CoA C00898 (R,R)-Tartaric acid C00975 Dihydroxyfumarate C00988 2-Phosphoglycolate C01127 4-Hydroxy-2-oxoglutarate C01146 2-Hydroxy-3-oxopropanoate C01182 D-Ribulose 1,5-bisphosphate C01213 (R)-Methylmalonyl-CoA C01380 Ethylene glycol C01732 Mesaconate C01989 3-Ethylmalate C01990 3-Oxalomalate C02123 3-Propylmalate C02405 Formyl phosphate C03217 2-Hydroxy-3-oxoadipate C03459 2-Hydroxy-3-oxosuccinate C03548 trans-2,3-Epoxysuccinate C03561 (R)-3-Hydroxybutanoyl-CoA C03618 L-threo-3-Methylaspartate C04348 L-Malyl-CoA C06027 L-erythro-3-Methylmalyl-CoA C06028 2-Methylfumaryl-CoA C06049 N-Formylderivatives C18026 (2S)-Ethylmalonyl-CoA C18324 (2S)-Methylsuccinyl-CoA C20238 (2R)-Ethylmalonyl-CoA C22337 D-Ribulose 1-phosphate REFERENCE PMID:10978349 AUTHORS Njau RK, Herndon CA, Hawes JW. TITLE Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae. JOURNAL J Biol Chem 275:38780-6 (2000) DOI:10.1074/jbc.M007432200 REFERENCE PMID:18065535 AUTHORS Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G TITLE Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria. JOURNAL J Bacteriol 190:1366-74 (2008) DOI:10.1128/JB.01621-07 REFERENCE PMID:18819910 AUTHORS Erb TJ, Retey J, Fuchs G, Alber BE TITLE Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases. JOURNAL J Biol Chem 283:32283-93 (2008) DOI:10.1074/jbc.M805527200 REFERENCE PMID:9596633 AUTHORS Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM TITLE Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation. JOURNAL Plant Cell 10:741-52 (1998) DOI:10.1105/tpc.10.5.741 REFERENCE PMID:16407450 AUTHORS Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A TITLE Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco. JOURNAL Plant Physiol 140:444-56 (2006) DOI:10.1104/pp.105.071910 REFERENCE PMID:21252347 AUTHORS Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA TITLE A methylaspartate cycle in haloarchaea. JOURNAL Science 331:334-7 (2011) DOI:10.1126/science.1196544 REFERENCE PMID:11513957 AUTHORS Serrano JA, Bonete MJ TITLE Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii. JOURNAL Biochim Biophys Acta 1520:154-62 (2001) DOI:10.1016/S0167-4781(01)00263-9 REL_PATHWAY ko00010 Glycolysis / Gluconeogenesis ko00020 Citrate cycle (TCA cycle) ko00030 Pentose phosphate pathway ko00053 Ascorbate and aldarate metabolism ko00071 Fatty acid degradation ko00230 Purine metabolism ko00250 Alanine, aspartate and glutamate metabolism ko00260 Glycine, serine and threonine metabolism ko00620 Pyruvate metabolism ko00710 Carbon fixation by Calvin cycle ko00750 Vitamin B6 metabolism ko00910 Nitrogen metabolism ///