ENTRY       ko00603                     Pathway
NAME        Glycosphingolipid biosynthesis - globo and isoglobo series
CLASS       Metabolism; Glycan biosynthesis and metabolism
PATHWAY_MAP ko00603  Glycosphingolipid biosynthesis - globo and isoglobo series
MODULE      M00068  Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer [PATH:ko00603]
DBLINKS     GO: 0001576 1990387
ORTHOLOGY   K20736  alpha-1,3-galactosyltransferase 2 [EC:2.4.1.87]
            K00719  galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]
            K00722  globoside alpha-N-acetylgalactosaminyltransferase [EC:2.4.1.88]
            K01988  lactosylceramide 4-alpha-galactosyltransferase [EC:2.4.1.228]
            K01189  alpha-galactosidase [EC:3.2.1.22]
            K07406  alpha-galactosidase [EC:3.2.1.22]
            K07407  alpha-galactosidase [EC:3.2.1.22]
            K03877  beta-1,3-galactosyltransferase 5 [EC:2.4.1.-]
            K12373  hexosaminidase [EC:3.2.1.52]
            K01204  alpha-N-acetylgalactosaminidase [EC:3.2.1.49]
            K00718  galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]
            K00709  histo-blood group ABO system transferase [EC:2.4.1.40 2.4.1.37]
            K00780  beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:2.4.3.2 2.4.3.4]
            K03368  beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4B) [EC:2.4.3.2 2.4.3.4]
            K03371  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A) [EC:2.4.3.8]
            K03663  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase [EC:2.4.1.152]
COMPOUND    G00092  Lactosylceramide
            G00093  Globotriaosylceramide
            G00094  Globoside
            G00095  Forssman antigen
            G00096  IV3GalNAcb-Gb4Cer
            G00097  Galactosylgloboside
            G00098  Monosialylgalactosylgloboside
            G00099  Globo-H
            G00100  V3(NeuAc)2-Gb5Cer
            G00101
            G00102
            G00103
            G00104
            G00105  GalGb3Cer
            G00106
            G00107
            G00181  Disialosylglobopentaosylceramide
            G00392  iGb4-Cer
            G00403  iGb3-Cer
            G00474  Globo-A
            G02977
            G11492  IV4-alpha-Gal-Gb4Cer
            G13080  NORint
            G13081  NOR2 antigen
            G13341  Globo-B
REFERENCE   PMID:12716912
  AUTHORS   Saito S, Aoki H, Ito A, Ueno S, Wada T, Mitsuzuka K, Satoh M, Arai Y, Miyagi T.
  TITLE     Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.
  JOURNAL   J Biol Chem 278:26474-9 (2003)
            DOI:10.1074/jbc.M213223200
REFERENCE   PMID:10837462
  AUTHORS   Zhou D, Henion TR, Jungalwala FB, Berger EG, Hennet T.
  TITLE     The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase.
  JOURNAL   J Biol Chem 275:22631-4 (2000)
            DOI:10.1074/jbc.C000263200
REFERENCE   PMID:10748143
  AUTHORS   Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  TITLE     Molecular cloning of globotriaosylceramide/CD77 synthase, aglycosyltransferase that initiates the synthesis of globo seriesglycosphingolipids.
  JOURNAL   J Biol Chem 275:15152-6 (2000)
            DOI:10.1074/jbc.M909620199
REFERENCE   PMID:10854428
  AUTHORS   Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU.
  TITLE     Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipidsynthesis, predicts a family of alpha 1, 4-glycosyltransferases conservedin plants, insects, and mammals.
  JOURNAL   J Biol Chem 275:25315-21 (2000)
            DOI:10.1074/jbc.M002630200
REFERENCE   PMID:10854427
  AUTHORS   Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU
  TITLE     Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids.
  JOURNAL   J Biol Chem 275:25308-14 (2000)
            DOI:10.1074/jbc.M002629200
REL_PATHWAY ko00600  Sphingolipid metabolism
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