ENTRY ko00600 Pathway NAME Sphingolipid metabolism CLASS Metabolism; Lipid metabolism PATHWAY_MAP ko00600 Sphingolipid metabolism MODULE M00066 Lactosylceramide biosynthesis [PATH:ko00600] M00067 Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:ko00600] M00094 Ceramide biosynthesis [PATH:ko00600] M00099 Sphingosine biosynthesis [PATH:ko00600] M00100 Sphingosine degradation [PATH:ko00600] DBLINKS GO: 0006665 ORTHOLOGY K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00720 UGCG; ceramide glucosyltransferase [EC:2.4.1.80] K00725 B4GALNT1, GALGT; (N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase [EC:2.4.1.92] K01019 GAL3ST1; galactosylceramide sulfotransferase [EC:2.8.2.11] K01080 PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4] K01117 sph; sphingomyelin phosphodiesterase [EC:3.1.4.12] K01123 SMaseD; sphingomyelin phosphodiesterase D [EC:3.1.4.41] K01130 atsA, aslA; arylsulfatase [EC:3.1.6.1] K01134 ARSA; arylsulfatase A [EC:3.1.6.8] K01186 NEU1; sialidase-1 [EC:3.2.1.18] K01189 GLA; alpha-galactosidase [EC:3.2.1.22] K01190 lacZ; beta-galactosidase [EC:3.2.1.23] K01201 GBA, srfJ; glucosylceramidase [EC:3.2.1.45] K01202 GALC; galactosylceramidase [EC:3.2.1.46] K01441 ACER1_2, ASAH3; alkaline ceramidase [EC:3.5.1.23] K01634 SGPL1, DPL1; sphinganine-1-phosphate aldolase [EC:4.1.2.27] K04628 CGT, UGT8; ceramide galactosyltransferase [EC:2.4.1.47] K04708 KDSR; 3-dehydrosphinganine reductase [EC:1.1.1.102] K04709 LAG1, LAC1; very-long-chain ceramide synthase [EC:2.3.1.297] K04710 CERS1, LASS1; sphingoid base N-stearoyltransferase [EC:2.3.1.299] K04711 ACER3, YDC1; dihydroceramidase [EC:3.5.1.-] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04713 SUR2; sphinganine C4-monooxygenase [EC:1.14.18.5] K04714 SGMS; sphingomyelin synthase / ceramide phosphoethanolamine synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.27 2.7.8.48 3.1.4.62] K04715 CERK; ceramide kinase [EC:2.7.1.138] K04716 SGPP1; sphingosine-1-phosphate phosphatase 1 [EC:3.1.3.-] K04717 SGPP2; sphingosine-1-phosphate phosphotase 2 [EC:3.1.3.-] K04718 SPHK; sphingosine kinase [EC:2.7.1.91] K05848 YPC1; phytoceramidase [EC:3.5.1.-] K07406 melA; alpha-galactosidase [EC:3.2.1.22] K07407 E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22] K07553 B4GALT6; beta-1,4-galactosyltransferase 6 [EC:2.4.1.274] K09905 B4GALT5; beta-1,4-galactosyltransferase 5 [EC:2.4.1.274 2.4.1.-] K12309 GLB1, ELNR1; beta-galactosidase [EC:3.2.1.23] K12348 ASAH1; acid ceramidase [EC:3.5.1.23] K12349 ASAH2; neutral ceramidase [EC:3.5.1.23] K12350 SMPD1, ASM; sphingomyelin phosphodiesterase [EC:3.1.4.12] K12351 SMPD2; sphingomyelin phosphodiesterase 2 [EC:3.1.4.12] K12352 SMPD3; sphingomyelin phosphodiesterase 3 [EC:3.1.4.12] K12353 SMPD4; sphingomyelin phosphodiesterase 4 [EC:3.1.4.12] K12354 ENPP7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [EC:3.1.4.12] K12357 NEU2_3_4; sialidase-2/3/4 [EC:3.2.1.18] K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] K12382 PSAP, SGP1; saposin K12383 GM2A; ganglioside GM2 activator K17108 GBA2; non-lysosomal glucosylceramidase [EC:3.2.1.45] K22697 SAMD8; ceramide phosphoethanolamine synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.48 3.1.4.62] K23451 LCB3; dihydrosphingosine 1-phosphate phosphatase K23550 nanH; sialidase K23727 CERS5_6, LASS5_6; sphingoid base N-palmitoyltransferase K24621 CERS2_4, LASS2_4; very-long-chain ceramide synthase K24622 CERS3, LASS3; very-long-chain ceramide synthase / ultra-long-chain ceramide synthase K26283 CPES; ceramide phosphoethanolamine synthase K28194 LOH1_3; very-long-chain ceramide synthase K28195 LOH2; ceramide synthase K28560 bcerS; bacterial ceramide synthase K28561 cerR; ceramide reductase K28874 spmT; sphingomyelin phosphodiesterase COMPOUND C00065 L-Serine C00154 Palmitoyl-CoA C00195 N-Acylsphingosine C00319 Sphingosine C00346 Ethanolamine phosphate C00550 Sphingomyelin C00836 Sphinganine C01120 Sphinganine 1-phosphate C01190 Glucosylceramide C01290 Lactosylceramide C01747 Psychosine C02686 Galactosylceramide C02934 3-Dehydrosphinganine C02960 Ceramide 1-phosphate C03108 D-Glucosylsphingosine C03272 Globoside C03405 Lactosylceramide sulfate C03640 Sphingosyl-phosphocholine C04730 GM3 C04737 alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide C04884 N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide C04911 D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide C05681 Ceramide 2-aminoethylphosphonate C06062 Ceramide phosphoethanolamine C06124 Sphingosine 1-phosphate C06125 Sulfatide C06126 Digalactosylceramide C06127 Digalactosylceramide sulfate C06128 GM4 C06135 GA2 C06136 GA1 C12126 Dihydroceramide C12144 Phytosphingosine C12145 Phytoceramide C22467 Gangliotriaosylceramide-II3 sulfate C23072 Oxidized ceramide REFERENCE PMID:12011104 AUTHORS Merrill AH Jr. TITLE De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. JOURNAL J Biol Chem 277:25843-6 (2002) DOI:10.1074/jbc.R200009200 REFERENCE PMID:10652340 AUTHORS Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M. TITLE Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. JOURNAL J Biol Chem 275:3462-8 (2000) DOI:10.1074/jbc.275.5.3462 REFERENCE PMID:11305904 AUTHORS Hannun YA, Luberto C, Argraves KM. TITLE Enzymes of sphingolipid metabolism: from modular to integrative signaling. JOURNAL Biochemistry 40:4893-903 (2001) DOI:10.1021/bi002836k REFERENCE PMID:1495423 AUTHORS Merrill AH Jr, Wang E. TITLE Enzymes of ceramide biosynthesis. JOURNAL Methods Enzymol 209:427-37 (1992) DOI:10.1016/0076-6879(92)09053-6 REFERENCE PMID:8457204 AUTHORS Hirschberg K, Rodger J, Futerman AH. TITLE The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. JOURNAL Biochem J 290 ( Pt 3):751-7 (1993) DOI:10.1042/bj2900751 REFERENCE PMID:10366774 AUTHORS Dickson RC, Lester RL. TITLE Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. JOURNAL Biochim Biophys Acta 1438:305-21 (1999) DOI:10.1016/S1388-1981(99)00068-2 REL_PATHWAY ko00260 Glycine, serine and threonine metabolism ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko00604 Glycosphingolipid biosynthesis - ganglio series ///