ENTRY ko00564 Pathway NAME Glycerophospholipid metabolism CLASS Metabolism; Lipid metabolism PATHWAY_MAP ko00564 Glycerophospholipid metabolism MODULE M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:ko00564] M00091 Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:ko00564] M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:ko00564] M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:ko00564] DBLINKS GO: 0006650 ORTHOLOGY K00006 GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8] K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] K00096 araM, egsA; glycerol-1-phosphate dehydrogenase [NAD(P)+] [EC:1.1.1.261] K00105 glpO; alpha-glycerophosphate oxidase [EC:1.1.3.21] K00111 glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3] K00112 glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3] K00113 glpC; glycerol-3-phosphate dehydrogenase subunit C K00550 PLMT; phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.71] K00551 PEMT; phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71] K00570 pmtA; phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71] K00623 CHAT; choline O-acetyltransferase [EC:2.3.1.6] K00629 GPAT1_2; glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15] K00630 ATS1; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15] K00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15] K00649 GNPAT; glyceronephosphate O-acyltransferase [EC:2.3.1.42] K00650 LCAT; lecithin-cholesterol acyltransferase [EC:2.3.1.43] K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] K00866 CKI1; choline kinase [EC:2.7.1.32] K00894 ETNK, EKI; ethanolamine kinase [EC:2.7.1.82] K00901 dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107] K00967 PCYT2; ethanolamine-phosphate cytidylyltransferase [EC:2.7.7.14] K00968 PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15] K00980 tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39] K00981 E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41] K00993 EPT1; ethanolaminephosphotransferase [EC:2.7.8.1] K00994 CHPT1, CPT1; diacylglycerol cholinephosphotransferase [EC:2.7.8.2] K00995 PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] K00998 pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8] K00999 CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11] K01004 pcs; phosphatidylcholine synthase [EC:2.7.8.24] K01047 PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4] K01048 pldB; lysophospholipase [EC:3.1.1.5] K01049 ACHE; acetylcholinesterase [EC:3.1.1.7] K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4] K01080 PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4] K01094 GEP4, pgpP; phosphatidylglycerophosphatase [EC:3.1.3.27] K01095 pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27] K01096 pgpB; phosphatidylglycerophosphatase B [EC:3.1.3.27 3.6.1.75 3.1.3.4 3.6.1.27] K01114 plc; phospholipase C [EC:3.1.4.3] K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4] K01126 E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] K01517 ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [EC:3.6.1.13 3.6.1.16 3.6.1.53] K01521 cdh; CDP-diacylglycerol pyrophosphatase [EC:3.6.1.26] K01613 psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65] K03735 eutB; ethanolamine ammonia-lyase large subunit [EC:4.3.1.7] K03736 eutC; ethanolamine ammonia-lyase small subunit [EC:4.3.1.7] K04019 eutA; ethanolamine utilization protein EutA K04714 SGMS; sphingomyelin synthase / ceramide phosphoethanolamine synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.27 2.7.8.48 3.1.4.62] K05929 E2.1.1.103, NMT; phosphoethanolamine N-methyltransferase [EC:2.1.1.103] K05939 aas; acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20] K06123 AYR1; 1-acylglycerone phosphate reductase [EC:1.1.1.101] K06124 PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase [EC:3.1.3.75] K06128 LYPLA1; lysophospholipase I [EC:3.1.1.5] K06129 LYPLA3; lysophospholipase III [EC:3.1.1.5] K06130 LYPLA2; lysophospholipase II [EC:3.1.1.5] K06131 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] K06132 clsC; cardiolipin synthase C [EC:2.7.8.-] K06900 capV; cGAMP-activated phospholipase [EC:3.1.1.32 3.1.1.-] K07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107] K07094 pcrB; heptaprenylglyceryl phosphate synthase [EC:2.5.1.-] K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] K08729 PTDSS1; phosphatidylserine synthase 1 [EC:2.7.8.-] K08730 PTDSS2; phosphatidylserine synthase 2 [EC:2.7.8.29] K08744 CRLS; cardiolipin synthase (CMP-forming) [EC:2.7.8.41] K13333 PLB; lysophospholipase [EC:3.1.1.5] K13506 GPAT3_4, AGPAT9, AGPAT6; glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15] K13507 GAT; glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase [EC:2.3.1.15 2.3.1.42] K13508 GPAT; glycerol-3-phosphate acyltransferase [EC:2.3.1.15 2.3.1.198] K13509 AGPAT1_2; lysophosphatidate acyltransferase [EC:2.3.1.51] K13510 LPCAT1_2; lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67] K13511 TAZ; monolysocardiolipin acyltransferase [EC:2.3.1.-] K13512 LPCAT4, AGPAT7; lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-] K13513 LCLAT1, AGPAT8; lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51] K13514 LPGAT1; lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-] K13515 LPCAT3, MBOAT5; lysophospholipid acyltransferase 5 [EC:2.3.1.23 2.3.1.-] K13516 MBOAT7; lysophospholipid acyltransferase 7 [EC:2.3.1.-] K13517 MBOAT1_2; lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-] K13519 LPT1, ALE1; lysophospholipid acyltransferase [EC:2.3.1.51 2.3.1.23 2.3.1.-] K13523 AGPAT3_4; lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-] K13535 CLD1; cardiolipin-specific phospholipase [EC:3.1.1.-] K13618 PLA1A; phosphatidylserine sn-1 acylhydrolase [EC:3.1.1.111] K13621 BTA1; betaine lipid synthase K13622 btaA; S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase K13623 btaB; S-adenosylmethionine-diacylgycerolhomoserine-N-methlytransferase K13644 CEPT1; choline/ethanolamine phosphotransferase [EC:2.7.8.1 2.7.8.2] K14156 CHK; choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82] K14286 AGXT2L1, ETNPPL; ethanolamine-phosphate phospho-lyase [EC:4.2.3.2] K14621 PLB1, PLB; phospholipase B1, membrane-associated [EC:3.1.1.4 3.1.1.5] K14674 TGL4; TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51] K14676 NTE, NRE; lysophospholipid hydrolase [EC:3.1.1.5] K15728 LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4] K16342 PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4] K16343 PLA2G6, IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4] K16368 DGK1; diacylglycerol kinase (CTP) [EC:2.7.1.174] K16369 CHO2; phosphatidylethanolamine N-methyltransferase [EC:2.1.1.17] K16619 plc, cpa; phospholipase C / alpha-toxin [EC:3.1.4.3] K16817 PLA2G16; HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4] K16818 DAD1; phospholipase A1 [EC:3.1.1.32] K16860 PLD3_4; phospholipase D3/4 [EC:3.1.4.4] K17103 CHO1, pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8] K17104 E2.5.1.41; phosphoglycerol geranylgeranyltransferase [EC:2.5.1.41] K17105 E2.5.1.42; geranylgeranylglycerol-phosphate geranylgeranyltransferase [EC:2.5.1.42] K17717 pld; phospholipase D [EC:3.1.4.4] K17830 GGR; digeranylgeranylglycerophospholipid reductase [EC:1.3.1.101 1.3.7.11] K18693 DPP1, DPPL, PLPP4_5; diacylglycerol diphosphate phosphatase / phosphatidate phosphatase [EC:3.6.1.75 3.1.3.4] K18694 PGC1; phosphatidylglycerol phospholipase C [EC:3.1.4.-] K18695 GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2] K18696 GDE1; glycerophosphodiester phosphodiesterase [EC:3.1.4.46] K18697 pgpC; phosphatidylglycerophosphatase C [EC:3.1.3.27] K19007 AGPAT5; lysophosphatidiate acyltransferase [EC:2.3.1.51] K19664 carS; CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase [EC:2.7.7.67] K19665 pssA; archaetidylserine synthase [EC:2.7.8.38] K21830 pchP; phosphoethanolamine/phosphocholine phosphatase [EC:3.1.3.75] K22389 LCAT3; phospholipase A1 [EC:3.1.1.32] K22697 SAMD8; ceramide phosphoethanolamine synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.48 3.1.4.62] K22831 LOA1; 1-acylglycerol-3-phosphate O-acyltransferase [EC:2.3.1.51] K24872 yvoF; heptaprenylglycerol acetyltransferase K25193 SDC; serine decarboxylase K28477 glpD; glycerol-3-phosphate oxidase K28873 GDPD5; glycerophosphocholine phosphodiesterase COMPOUND C00040 Acyl-CoA C00065 L-Serine C00084 Acetaldehyde C00093 sn-Glycerol 3-phosphate C00111 Glycerone phosphate C00114 Choline C00157 Phosphatidylcholine C00189 Ethanolamine C00269 CDP-diacylglycerol C00307 CDP-choline C00344 Phosphatidylglycerol C00346 Ethanolamine phosphate C00350 Phosphatidylethanolamine C00416 Phosphatidate C00513 CDP-glycerol C00570 CDP-ethanolamine C00588 Choline phosphate C00623 sn-Glycerol 1-phosphate C00641 1,2-Diacyl-sn-glycerol C00670 sn-Glycero-3-phosphocholine C00681 1-Acyl-sn-glycerol 3-phosphate C01194 1-Phosphatidyl-D-myo-inositol C01210 N-Methylethanolamine phosphate C01233 sn-Glycero-3-phosphoethanolamine C01241 Phosphatidyl-N-methylethanolamine C01996 Acetylcholine C02737 Phosphatidylserine C03372 Acylglycerone phosphate C03819 1-Acylglycerophosphoinositol C03872 L-Serine-phosphoethanolamine C03892 Phosphatidylglycerophosphate C03974 2-Acyl-sn-glycerol 3-phosphate C04230 1-Acyl-sn-glycero-3-phosphocholine C04233 2-Acyl-sn-glycero-3-phosphocholine C04308 Phosphatidyl-N-dimethylethanolamine C04438 1-Acyl-sn-glycero-3-phosphoethanolamine C04590 3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate C04638 2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate C05973 2-Acyl-sn-glycero-3-phosphoethanolamine C05974 2-Acyl-sn-glycero-3-phosphoserine C05976 Aminoacyl-phosphatidylglycerol C05980 Cardiolipin C06771 Triethanolamine C06772 Diethanolamine C13482 Phosphodimethylethanolamine C18059 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol C18125 1-Acyl-sn-glycero-3-phosphoserine C18126 1-Acyl-sn-glycero-3-phosphoglycerol C18129 Monolysocardiolipin C18168 Diacylglycerylhomoserine C18169 Diacylglyceryl-N,N,N-trimethylhomoserine C20466 2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine C20518 2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate C22340 Heptaprenylglyceryl phosphate C22341 Heptaprenylglycerol C22342 Diacetylheptaprenylglycerol REFERENCE PMID:1512203 AUTHORS Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML. TITLE The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae. JOURNAL J Bacteriol 174:5702-10 (1992) DOI:10.1128/JB.174.17.5702-5710.1992 REFERENCE PMID:10092508 AUTHORS Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M. TITLE Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. JOURNAL Biochem Biophys Res Commun 257:50-6 (1999) DOI:10.1006/bbrc.1999.0411 REFERENCE PMID:10542045 AUTHORS Athenstaedt K, Daum G. TITLE Phosphatidic acid, a key intermediate in lipid metabolism. JOURNAL Eur J Biochem 266:1-16 (1999) DOI:10.1046/j.1432-1327.1999.00822.x REFERENCE PMID:12431977 AUTHORS Shields DJ, Lehner R, Agellon LB, Vance DE. TITLE Membrane topography of human phosphatidylethanolamine N-methyltransferase. JOURNAL J Biol Chem 278:2956-62 (2003) DOI:10.1074/jbc.M210904200 REFERENCE PMID:14663079 AUTHORS Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O. TITLE Pathways for phosphatidylcholine biosynthesis in bacteria. JOURNAL Microbiology 149:3461-71 (2003) DOI:10.1099/mic.0.26522-0 REFERENCE PMID:15522832 AUTHORS Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G. TITLE Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae. JOURNAL Biochim Biophys Acta 1686:161-8 (2004) DOI:10.1016/j.bbalip.2004.09.007 REFERENCE PMID:1649829 AUTHORS Hsu L, Jackowski S, Rock CO TITLE Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity. JOURNAL J Biol Chem 266:13783-8 (1991) REFERENCE PMID:10938271 AUTHORS Stone SJ, Vance JE. TITLE Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes. JOURNAL J Biol Chem 275:34534-40 (2000) DOI:10.1074/jbc.M002865200 REL_PATHWAY ko00010 Glycolysis / Gluconeogenesis ko00260 Glycine, serine and threonine metabolism ko00561 Glycerolipid metabolism ko00562 Inositol phosphate metabolism ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ko00565 Ether lipid metabolism ko00620 Pyruvate metabolism ///