ENTRY ko00564 Pathway NAME Glycerophospholipid metabolism CLASS Metabolism; Lipid metabolism PATHWAY_MAP ko00564 Glycerophospholipid metabolism MODULE M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:ko00564] M00091 Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:ko00564] M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:ko00564] M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:ko00564] DBLINKS GO: 0006650 ORTHOLOGY K00006 glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8] K00057 glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] K00105 alpha-glycerophosphate oxidase [EC:1.1.3.21] K00111 glycerol-3-phosphate dehydrogenase [EC:1.1.5.3] K00112 glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3] K00113 glycerol-3-phosphate dehydrogenase subunit C K00629 glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15] K13506 glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15] K13507 glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase [EC:2.3.1.15 2.3.1.42] K00630 glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15] K13508 glycerol-3-phosphate acyltransferase [EC:2.3.1.15 2.3.1.198] K00631 glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15] K08591 acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] K00655 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] K13509 lysophosphatidate acyltransferase [EC:2.3.1.51] K13523 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-] K19007 lysophosphatidiate acyltransferase [EC:2.3.1.51] K13513 lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51] K13517 lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-] K13519 lysophospholipid acyltransferase [EC:2.3.1.51 2.3.1.23 2.3.1.-] K14674 TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51] K22831 1-acylglycerol-3-phosphate O-acyltransferase [EC:2.3.1.51] K00649 glyceronephosphate O-acyltransferase [EC:2.3.1.42] K06123 1-acylglycerone phosphate reductase [EC:1.1.1.101] K00980 glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39] K01517 manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [EC:3.6.1.13 3.6.1.16 3.6.1.53] K01080 phosphatidate phosphatase [EC:3.1.3.4] K15728 phosphatidate phosphatase LPIN [EC:3.1.3.4] K18693 diacylglycerol diphosphate phosphatase / phosphatidate phosphatase [EC:3.6.1.75 3.1.3.4] K00901 diacylglycerol kinase (ATP) [EC:2.7.1.107] K07029 diacylglycerol kinase (ATP) [EC:2.7.1.107] K16368 diacylglycerol kinase (CTP) [EC:2.7.1.174] K00994 diacylglycerol cholinephosphotransferase [EC:2.7.8.2] K13644 choline/ethanolamine phosphotransferase [EC:2.7.8.1 2.7.8.2] K01114 phospholipase C [EC:3.1.4.3] K16619 phospholipase C / alpha-toxin [EC:3.1.4.3] K22697 phosphatidylethanolamine phospholipase C [EC:3.1.4.62] K04714 sphingomyelin synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.27 3.1.4.62] K18694 phosphatidylglycerol phospholipase C [EC:3.1.4.-] K01115 phospholipase D1/2 [EC:3.1.4.4] K16860 phospholipase D3/4 [EC:3.1.4.4] K17717 phospholipase D [EC:3.1.4.4] K00650 lecithin-cholesterol acyltransferase [EC:2.3.1.43] K01047 secretory phospholipase A2 [EC:3.1.1.4] K16342 cytosolic phospholipase A2 [EC:3.1.1.4] K16343 calcium-independent phospholipase A2 [EC:3.1.1.4] K14621 phospholipase B1, membrane-associated [EC:3.1.1.4 3.1.1.5] K16817 HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4] K01058 phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4] K13510 lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67] K13512 lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-] K13515 lysophospholipid acyltransferase 5 [EC:2.3.1.23 2.3.1.-] K16818 phospholipase A1 [EC:3.1.1.32] K22389 phospholipase A1 [EC:3.1.1.32] K06900 cGAMP-activated phospholipase [EC:3.1.1.32 3.1.1.-] K06128 lysophospholipase I [EC:3.1.1.5] K06129 lysophospholipase III [EC:3.1.1.5] K06130 lysophospholipase II [EC:3.1.1.5] K13333 lysophospholipase [EC:3.1.1.5] K01048 lysophospholipase [EC:3.1.1.5] K14676 lysophospholipid hydrolase [EC:3.1.1.5] K18695 glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2] K18696 glycerophosphodiester phosphodiesterase [EC:3.1.4.46] K01126 glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] K00623 choline O-acetyltransferase [EC:2.3.1.6] K01049 acetylcholinesterase [EC:3.1.1.7] K00866 choline kinase [EC:2.7.1.32] K14156 choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82] K06124 phosphoethanolamine/phosphocholine phosphatase [EC:3.1.3.75] K00968 choline-phosphate cytidylyltransferase [EC:2.7.7.15] K00993 ethanolaminephosphotransferase [EC:2.7.8.1] K05939 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20] K25193 serine decarboxylase [EC:4.1.1.-] K00894 ethanolamine kinase [EC:2.7.1.82] K00967 ethanolamine-phosphate cytidylyltransferase [EC:2.7.7.14] K05929 phosphoethanolamine N-methyltransferase [EC:2.1.1.103] K04019 ethanolamine utilization protein EutA K03735 ethanolamine ammonia-lyase large subunit [EC:4.3.1.7] K03736 ethanolamine ammonia-lyase small subunit [EC:4.3.1.7] K14286 ethanolamine-phosphate phospho-lyase [EC:4.2.3.2] K00551 phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71] K16369 phosphatidylethanolamine N-methyltransferase [EC:2.1.1.17] K00550 phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.71] K00570 phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71] K01521 CDP-diacylglycerol pyrophosphatase [EC:3.6.1.26] K00981 phosphatidate cytidylyltransferase [EC:2.7.7.41] K01004 phosphatidylcholine synthase [EC:2.7.8.24] K00998 CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8] K17103 CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8] K13618 phosphatidylserine sn-1 acylhydrolase [EC:3.1.1.111] K08729 phosphatidylserine synthase 1 [EC:2.7.8.-] K08730 phosphatidylserine synthase 2 [EC:2.7.8.29] K01613 phosphatidylserine decarboxylase [EC:4.1.1.65] K00995 CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] K01094 phosphatidylglycerophosphatase GEP4 [EC:3.1.3.27] K01095 phosphatidylglycerophosphatase A [EC:3.1.3.27] K01096 phosphatidylglycerophosphatase B [EC:3.1.3.27 3.6.1.75 3.1.3.4 3.6.1.27] K18697 phosphatidylglycerophosphatase C [EC:3.1.3.27] K06131 cardiolipin synthase A/B [EC:2.7.8.-] K06132 cardiolipin synthase C [EC:2.7.8.-] K08744 cardiolipin synthase (CMP-forming) [EC:2.7.8.41] K13511 monolysocardiolipin acyltransferase [EC:2.3.1.-] K13535 cardiolipin-specific phospholipase [EC:3.1.1.-] K13514 lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-] K00999 CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11] K13516 lysophospholipid acyltransferase 7 [EC:2.3.1.-] K13621 betaine lipid synthase K13622 S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase K13623 S-adenosylmethionine-diacylgycerolhomoserine-N-methlytransferase K00096 glycerol-1-phosphate dehydrogenase [NAD(P)+] [EC:1.1.1.261] K17104 phosphoglycerol geranylgeranyltransferase [EC:2.5.1.41] K17105 geranylgeranylglycerol-phosphate geranylgeranyltransferase [EC:2.5.1.42] K19664 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase [EC:2.7.7.67] K19665 archaetidylserine synthase [EC:2.7.8.38] K17830 digeranylgeranylglycerophospholipid reductase [EC:1.3.1.101 1.3.7.11] K07094 heptaprenylglyceryl phosphate synthase [EC:2.5.1.-] K24872 heptaprenylglycerol acetyltransferase [EC:2.3.1.-] COMPOUND C00040 Acyl-CoA C00065 L-Serine C00084 Acetaldehyde C00093 sn-Glycerol 3-phosphate C00111 Glycerone phosphate C00114 Choline C00157 Phosphatidylcholine C00189 Ethanolamine C00269 CDP-diacylglycerol C00307 CDP-choline C00344 Phosphatidylglycerol C00346 Ethanolamine phosphate C00350 Phosphatidylethanolamine C00416 Phosphatidate C00513 CDP-glycerol C00570 CDP-ethanolamine C00588 Choline phosphate C00623 sn-Glycerol 1-phosphate C00641 1,2-Diacyl-sn-glycerol C00670 sn-Glycero-3-phosphocholine C00681 1-Acyl-sn-glycerol 3-phosphate C01194 1-Phosphatidyl-D-myo-inositol C01210 N-Methylethanolamine phosphate C01233 sn-Glycero-3-phosphoethanolamine C01241 Phosphatidyl-N-methylethanolamine C01996 Acetylcholine C02737 Phosphatidylserine C03372 Acylglycerone phosphate C03819 1-Acylglycerophosphoinositol C03872 L-Serine-phosphoethanolamine C03892 Phosphatidylglycerophosphate C03974 2-Acyl-sn-glycerol 3-phosphate C04230 1-Acyl-sn-glycero-3-phosphocholine C04233 2-Acyl-sn-glycero-3-phosphocholine C04308 Phosphatidyl-N-dimethylethanolamine C04438 1-Acyl-sn-glycero-3-phosphoethanolamine C04590 3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate C04638 2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate C05973 2-Acyl-sn-glycero-3-phosphoethanolamine C05974 2-Acyl-sn-glycero-3-phosphoserine C05976 Aminoacyl-phosphatidylglycerol C05980 Cardiolipin C06771 Triethanolamine C06772 Diethanolamine C13482 Phosphodimethylethanolamine C18059 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol C18125 1-Acyl-sn-glycero-3-phosphoserine C18126 1-Acyl-sn-glycero-3-phosphoglycerol C18129 Monolysocardiolipin C18168 Diacylglycerylhomoserine C18169 Diacylglyceryl-N,N,N-trimethylhomoserine C20466 2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine C20518 2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate C22340 Heptaprenylglyceryl phosphate C22341 Heptaprenylglycerol C22342 Diacetylheptaprenylglycerol REFERENCE PMID:1512203 AUTHORS Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML. TITLE The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae. JOURNAL J Bacteriol 174:5702-10 (1992) DOI:10.1128/JB.174.17.5702-5710.1992 REFERENCE PMID:10092508 AUTHORS Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M. TITLE Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. JOURNAL Biochem Biophys Res Commun 257:50-6 (1999) DOI:10.1006/bbrc.1999.0411 REFERENCE PMID:10542045 AUTHORS Athenstaedt K, Daum G. TITLE Phosphatidic acid, a key intermediate in lipid metabolism. JOURNAL Eur J Biochem 266:1-16 (1999) DOI:10.1046/j.1432-1327.1999.00822.x REFERENCE PMID:12431977 AUTHORS Shields DJ, Lehner R, Agellon LB, Vance DE. TITLE Membrane topography of human phosphatidylethanolamine N-methyltransferase. JOURNAL J Biol Chem 278:2956-62 (2003) DOI:10.1074/jbc.M210904200 REFERENCE PMID:14663079 AUTHORS Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O. TITLE Pathways for phosphatidylcholine biosynthesis in bacteria. JOURNAL Microbiology 149:3461-71 (2003) DOI:10.1099/mic.0.26522-0 REFERENCE PMID:15522832 AUTHORS Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G. TITLE Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae. JOURNAL Biochim Biophys Acta 1686:161-8 (2004) DOI:10.1016/j.bbalip.2004.09.007 REFERENCE PMID:1649829 AUTHORS Hsu L, Jackowski S, Rock CO TITLE Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity. JOURNAL J Biol Chem 266:13783-8 (1991) REFERENCE PMID:10938271 AUTHORS Stone SJ, Vance JE. TITLE Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes. JOURNAL J Biol Chem 275:34534-40 (2000) DOI:10.1074/jbc.M002865200 REL_PATHWAY ko00010 Glycolysis / Gluconeogenesis ko00260 Glycine, serine and threonine metabolism ko00561 Glycerolipid metabolism ko00562 Inositol phosphate metabolism ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ko00565 Ether lipid metabolism ko00620 Pyruvate metabolism ///