ENTRY       ko00531                     Pathway
NAME        Glycosaminoglycan degradation
CLASS       Metabolism; Glycan biosynthesis and metabolism
PATHWAY_MAP ko00531  Glycosaminoglycan degradation
MODULE      M00076  Dermatan sulfate degradation [PATH:ko00531]
            M00077  Chondroitin sulfate degradation [PATH:ko00531]
            M00078  Heparan sulfate degradation [PATH:ko00531]
            M00079  Keratan sulfate degradation [PATH:ko00531]
DBLINKS     GO: 0006027
ORTHOLOGY   K01132  GALNS; N-acetylgalactosamine-6-sulfatase [EC:3.1.6.4]
            K01135  ARSB; arylsulfatase B [EC:3.1.6.12]
            K01136  IDS; iduronate 2-sulfatase [EC:3.1.6.13]
            K01137  GNS; N-acetylglucosamine-6-sulfatase [EC:3.1.6.14]
            K01195  uidA, GUSB; beta-glucuronidase [EC:3.2.1.31]
            K01197  hya; hyaluronoglucosaminidase [EC:3.2.1.35]
            K01205  NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50]
            K01207  nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52]
            K01217  IDUA; L-iduronidase [EC:3.2.1.76]
            K01565  SGSH; N-sulfoglucosamine sulfohydrolase [EC:3.10.1.1]
            K07964  HPSE; heparanase [EC:3.2.1.166]
            K07965  HPSE2; heparanase 2 [EC:3.2.1.-]
            K10532  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [EC:2.3.1.78]
            K12309  GLB1, ELNR1; beta-galactosidase [EC:3.2.1.23]
            K12373  HEXA_B; hexosaminidase [EC:3.2.1.52]
COMPOUND    C00426  Dermatan sulfate
            C00573  Keratan sulfate
            C00634  Chondroitin 4-sulfate
            C00925  Heparan sulfate
            G00526  
            G00711  
            G00872  DWA-2
            G01391  
            G01945  
            G01977  
            G02632  
            G09660  
            G10008  
            G10505  Hyaluronic acid
            G12336  
            G13034  
            G13035  
            G13036  
            G13037  
            G13038  
            G13039  
            G13040  
            G13041  
            G13042  
            G13043  
            G13073  
            G13074  
REFERENCE   PMID:27570
  AUTHORS   Greiling H, Stuhlsatz HW, Cantz M, Gehler J
  TITLE     Increased urinary excretion of keratan sulfate in fucosidosis.
  JOURNAL   J Clin Chem Clin Biochem 16:329-34 (1978)
            DOI:10.1515/cclm.1978.16.6.329
REFERENCE   PMID:3161730
  AUTHORS   Fuchs W, Beck M, Kresse H
  TITLE     Intralysosomal formation and metabolic fate of N-acetylglucosamine 6-sulfate from keratan sulfate.
  JOURNAL   Eur J Biochem 151:551-6 (1985)
            DOI:10.1111/j.1432-1033.1985.tb09138.x
REL_PATHWAY ko00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
            ko00533  Glycosaminoglycan biosynthesis - keratan sulfate
            ko00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
///