ENTRY ko00525 Pathway NAME Acarbose and validamycin biosynthesis CLASS Metabolism; Biosynthesis of other secondary metabolites PATHWAY_MAP ko00525 Acarbose and validamycin biosynthesis MODULE M00814 Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose [PATH:ko00525] M00815 Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A [PATH:ko00525] ORTHOLOGY K19969 2-epi-5-epi-valiolone synthase [EC:4.2.3.152] K19979 2-epi-5-epi-valiolone 7-kinase [EC:2.7.1.188] K19974 2-epi-5-epi-valiolone 7-phosphate 2-epimerase [EC:5.1.3.35] K20424 2-epi-valiolone-7-phosphate 1-reductase [EC:1.1.1.-] K20425 cyclitol oxidoreductase K20426 1-epi-valienol-7-phosphate kinase [EC:2.7.-.-] K20427 valienol-1-phosphate guanylyltransferase [EC:2.7.7.91] K00973 glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] K23144 UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.7.7.24 2.7.7.83 2.3.1.157 2.3.1.276] K01710 dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] K20428 dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33] K20430 glycosyltransferase AcbS [EC:2.4.-.-] K19978 acarbose 7IV-phosphotransferase [EC:2.7.1.187] K20431 2-epi-5-epi-valiolone epimerase [EC:5.1.3.33] K20432 5-epi-valiolone dehydratase [EC:4.2.1.-] K20433 C7-cyclitol 7-kinase [EC:2.7.1.214] K20434 cyclitol reductase K20435 validone 7-phosphate aminotransferase [EC:2.6.1.-] K20436 validamine 7-phosphate valienyltransferase [EC:2.5.1.135] K20437 validoxylamine A 7'-phosphate phosphatase [EC:3.1.3.101] K20438 validoxylamine A glucosyltransferase [EC:2.4.1.338] K21036 validamycin A dioxygenase [EC:1.14.11.52] K20439 putative phosphohexomutase / phosphatase K20440 salbostatin 6'-phosphate phosphatase [EC:3.1.3.-] K20441 5-epi-valiolone oxidase [EC:1.1.3.-] K20442 2-keto-5-epi-valolone aminotransferase [EC:2.6.1.-] K20443 cetoniacytone B acyltransferase [EC:2.3.1.-] COMPOUND C00103 D-Glucose 1-phosphate C00842 dTDP-glucose C04268 dTDP-4-amino-4,6-dideoxy-D-glucose C06802 Acarbose C11907 dTDP-4-oxo-6-deoxy-D-glucose C12112 Validamycin A C17691 2-epi-5-epi-Valiolone C17692 2-epi-5-epi-Valiolone 7-phosphate C17693 5-epi-Valiolone 7-phosphate C17694 5-epi-Valiolone C17695 2-Keto-5-epi-valiolone C17696 Valienone C17697 Valienone 7-phosphate C17698 Salbostatin C17699 Cetoniacytone A C17700 Validoxylamine A C20956 alpha-D-Sedoheptulopyranose 7-phosphate C21156 Acarbose 7IV-phosphate C21204 5-epi-Valiolol 7-phosphate C21205 1-epi-Valienol 7-phosphate C21206 1,7-Diphospho-1-epi-valienol C21207 NDP-1-epi-valienol 7-phosphate C21208 dTDP-acarviose-7-phosphate C21209 1-epi-Valienol 1-phosphate C21210 NDP-1-epi-valienol C21211 Salbostatin 6'-phosphate C21216 Validamine 7-phosphate C21218 Validone 7-phosphate C21219 Validoxylamine A 7'-phosphate C21247 2-Amino-5-epi-valiolone C21248 2-Aminovalienone C21249 Cetoniacytone B C21293 Validamycin B C21367 Valienol 1-phosphate C21368 GDP-valienol C21415 Valienol 7-phosphate REFERENCE PMID:17390001 AUTHORS Flatt PM, Mahmud T TITLE Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds. JOURNAL Nat Prod Rep 24:358-92 (2007) DOI:10.1039/b603816f REFERENCE PMID:17661520 AUTHORS Mahmud T, Flatt PM, Wu X TITLE Biosynthesis of unusual aminocyclitol-containing natural products. JOURNAL J Nat Prod 70:1384-91 (2007) DOI:10.1021/np070210q REFERENCE PMID:22944206 AUTHORS Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A TITLE The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism. JOURNAL J Biotechnol 167:178-89 (2013) DOI:10.1016/j.jbiotec.2012.08.011 REFERENCE PMID:22443545 AUTHORS Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A TITLE The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110. JOURNAL BMC Genomics 13:112 (2012) DOI:10.1186/1471-2164-13-112 REFERENCE PMID:17003911 AUTHORS Deng Z, Bai L TITLE Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China. JOURNAL Nat Prod Rep 23:811-27 (2006) DOI:10.1039/b611140h REFERENCE PMID:21766819 AUTHORS Asamizu S, Yang J, Almabruk KH, Mahmud T TITLE Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. JOURNAL J Am Chem Soc 133:12124-35 (2011) DOI:10.1021/ja203574u REFERENCE PMID:18648803 AUTHORS Choi WS, Wu X, Choeng YH, Mahmud T, Jeong BC, Lee SH, Chang YK, Kim CJ, Hong SK TITLE Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838. JOURNAL Appl Microbiol Biotechnol 80:637-45 (2008) DOI:10.1007/s00253-008-1591-2 REFERENCE PMID:19101977 AUTHORS Wu X, Flatt PM, Xu H, Mahmud T TITLE Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419. JOURNAL Chembiochem 10:304-14 (2009) DOI:10.1002/cbic.200800527 REL_PATHWAY ko00030 Pentose phosphate pathway ko00520 Amino sugar and nucleotide sugar metabolism ///