ENTRY       ko00450                     Pathway
NAME        Selenocompound metabolism
CLASS       Metabolism; Metabolism of other amino acids
PATHWAY_MAP ko00450  Selenocompound metabolism
ORTHOLOGY   K00384  trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]
            K00548  metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
            K00549  metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14]
            K00562  INMT, TEMT; methyltransferase [EC:2.1.1.49 2.1.1.96]
            K00816  CCBL; kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64]
            K00955  cysNC; bifunctional enzyme CysN/CysC [EC:2.7.7.4 2.7.1.25]
            K00956  cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4]
            K00957  cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]
            K00958  sat, met3; sulfate adenylyltransferase [EC:2.7.7.4]
            K01008  selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]
            K01042  selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]
            K01739  metB; cystathionine gamma-synthase [EC:2.5.1.48]
            K01758  CTH; cystathionine gamma-lyase [EC:4.4.1.1]
            K01760  metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
            K01761  E4.4.1.11; methionine-gamma-lyase [EC:4.4.1.11]
            K01763  SCLY; selenocysteine lyase [EC:4.4.1.16]
            K01874  MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]
            K03341  SEPSECS; O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase [EC:2.9.1.2]
            K07309  ynfE; Tat-targeted selenate reductase subunit YnfE [EC:1.97.1.9]
            K07310  ynfF; Tat-targeted selenate reductase subunit YnfF [EC:1.97.1.9]
            K08247  E2.1.1.12; methionine S-methyltransferase [EC:2.1.1.12]
            K10837  PSTK; O-phosphoseryl-tRNA(Sec) kinase [EC:2.7.1.164]
            K11717  sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]
            K12527  ygfK; putative selenate reductase [EC:1.97.1.9]
            K12528  xdhD; putative selenate reductase molybdopterin-binding subunit
            K12529  ygfM; putative selenate reductase FAD-binding subunit
            K13811  PAPSS; 3'-phosphoadenosine 5'-phosphosulfate synthase [EC:2.7.7.4 2.7.1.25]
            K14155  patB, malY; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
            K17050  serA, clrA; selenate/chlorate reductase subunit alpha [EC:1.97.1.9 1.97.1.1]
            K17051  serB, clrB; selenate/chlorate reductase subunit beta [EC:1.97.1.9 1.97.1.1]
            K17052  serC, clrC; selenate/chlorate reductase subunit gamma [EC:1.97.1.9 1.97.1.1]
            K22182  TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
            K24042  yitJ; methionine synthase / methylenetetrahydrofolate reductase (NADH)
            K27874  srdA; selenate reductase (quinol) subunit A
            K27875  srdB; selenate reductase (quinol) subunit B
            K27876  srdC; selenate reductase (quinol) subunit C
COMPOUND    C00017  Protein
            C00041  L-Alanine
            C01528  Hydrogen selenide
            C02535  Dimethyl selenide
            C05172  Selenophosphoric acid
            C05335  L-Selenomethionine
            C05336  Selenomethionyl-tRNA(Met)
            C05684  Selenite
            C05686  Adenylyl selenate
            C05688  L-Selenocysteine
            C05689  Se-Methyl-L-selenocysteine
            C05690  Se-Methylselenomethionine
            C05695  gamma-Glutamyl-Se-methylselenocysteine
            C05697  Selenate
            C05698  Selenohomocysteine
            C05699  L-Selenocystathionine
            C05703  Methaneselenol
            C06481  L-Seryl-tRNA(Sec)
            C06482  L-Selenocysteinyl-tRNA(Sec)
            C16638  O-Phosphoseryl-tRNA(Sec)
            C18870  Selenodiglutathione
            C18871  Glutathioselenol
            C18872  Trimethylselenonium
            C18893  1-Methylseleno-N-acetyl-D-galactosamine
            C18902  Methylselenic acid
            C18904  Methylselenopyruvate
            C18905  Methylselenocysteine Se-oxide
REFERENCE   PMID:21190829
  AUTHORS   Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  TITLE     Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  JOURNAL   J Nutr Biochem 22:945-55 (2011)
            DOI:10.1016/j.jnutbio.2010.08.006
REFERENCE   PMID:19051051
  AUTHORS   McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  TITLE     Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  JOURNAL   Transgenic Res 18:407-24 (2009)
            DOI:10.1007/s11248-008-9233-0
REFERENCE   PMID:20383543
  AUTHORS   Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  TITLE     Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds.
  JOURNAL   Amino Acids 41:29-41 (2011)
            DOI:10.1007/s00726-010-0578-3
REFERENCE   PMID:17451884
  AUTHORS   Suzuki KT, Kurasaki K, Suzuki N
  TITLE     Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  JOURNAL   Biochim Biophys Acta 1770:1053-61 (2007)
            DOI:10.1016/j.bbagen.2007.03.007
REFERENCE   PMID:11782468
  AUTHORS   Gromer S, Gross JH
  TITLE     Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  JOURNAL   J Biol Chem 277:9701-6 (2002)
            DOI:10.1074/jbc.M109234200
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