ENTRY ko00405 Pathway NAME Phenazine biosynthesis CLASS Metabolism; Biosynthesis of other secondary metabolites PATHWAY_MAP ko00405 Phenazine biosynthesis MODULE M00835 Pyocyanine biosynthesis, chorismate => pyocyanine [PATH:ko00405] ORTHOLOGY K13063 2-amino-4-deoxychorismate synthase [EC:2.6.1.86] K20261 trans-2,3-dihydro-3-hydroxyanthranilic acid synthase [EC:3.3.2.15] K06998 trans-2,3-dihydro-3-hydroxyanthranilate isomerase [EC:5.3.3.17] K20260 phenazine biosynthesis protein K20262 dihydrophenazinedicarboxylate synthase [EC:1.10.3.16] K21103 phenazine-1-carboxylate N-methyltransferase [EC:2.1.1.327] K20940 5-methylphenazine-1-carboxylate 1-monooxygenase [EC:1.14.13.218] K21338 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase [EC:2.5.1.121] K01657 anthranilate synthase component I [EC:4.1.3.27] K01658 anthranilate synthase component II [EC:4.1.3.27] K18000 anthranilate-CoA ligase [EC:6.2.1.32] K18003 anthraniloyl-CoA anthraniloyltransferase [EC:2.3.1.262] K20257 2-aminobenzoylacetyl-CoA thioesterase [EC:3.1.2.32] K18001 2-heptyl-4(1H)-quinolone synthase subunit PqsB [EC:2.3.1.230] K18002 2-heptyl-4(1H)-quinolone synthase subunit PqsC [EC:2.3.1.230] K17940 2-heptyl-3-hydroxy-4(1H)-quinolone synthase [EC:1.14.13.182] COMPOUND C00108 Anthranilate C00251 Chorismate C01748 Pyocyanine C01944 Octanoyl-CoA C02247 Anthraniloyl-CoA C11848 2-Heptyl-3-hydroxy-quinolone C12119 Phenazine-1,6-dicarboxylic acid C18054 2-Amino-2-deoxyisochorismate C19830 (5S,6S)-6-Amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate C19831 (1R,6S)-6-Amino-5-oxocyclohex-2-ene-1-carboxylate C20643 2-Heptyl-4(1H)-quinolone C20981 5,10-Dihydrophenazine-1-carboxylate C20982 9-(Dimethylallyl)-5,10-dihydrophenazine-1-carboxylate C21295 5-Methylphenazine-1-carboxylate C21408 (1R,6R)-1,4,5,5a,6,9-Hexahydrophenazine-1,6-dicarboxylate C21409 (1R,10aS)-1,4,10,10a-Tetrahydrophenazine-1,6-dicarboxylate C21410 (5aS)-5,5a-Dihydrophenazine-1,6-dicarboxylate C21411 (1R,10aS)-1,4,10,10a-Tetrahydrophenazine-1-carboxylate C21412 (10aS)-10,10a-Dihydrophenazine-1-carboxylate C21413 (1R)-1,4,5,10-Tetrahydrophenazine-1-carboxylate C21442 Phenazine-1-carboxylate C21452 (2-Aminobenzoyl)acetyl-CoA C21453 (2-Aminobenzoyl)acetate C21473 (1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate C21474 5,10-Dihydrophenazine-1,6-dicarboxylate C21475 5,10-Dihydrophenazine C21476 Phenazine C21477 1-Hydroxyphenazine C21488 S-Anthraniloyl-L-cysteinyl-protein C21489 S-Octanoyl-L-cysteinyl-protein C21490 1-(2-Aminophenyl)decane-1,3-dione REFERENCE PMID:23897464 AUTHORS Xu N, Ahuja EG, Janning P, Mavrodi DV, Thomashow LS, Blankenfeldt W TITLE Trapped intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of phenazine biosynthesis. JOURNAL Acta Crystallogr D Biol Crystallogr 69:1403-13 (2013) DOI:10.1107/S0907444913008354 REFERENCE PMID:20352425 AUTHORS Pierson LS 3rd, Pierson EA TITLE Metabolism and function of phenazines in bacteria: impacts on the behavior of bacteria in the environment and biotechnological processes. JOURNAL Appl Microbiol Biotechnol 86:1659-70 (2010) DOI:10.1007/s00253-010-2509-3 REFERENCE PMID:19053436 AUTHORS Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W TITLE PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis. JOURNAL J Am Chem Soc 130:17053-61 (2008) DOI:10.1021/ja806325k REFERENCE PMID:19658148 AUTHORS Mentel M, Ahuja EG, Mavrodi DV, Breinbauer R, Thomashow LS, Blankenfeldt W TITLE Of two make one: the biosynthesis of phenazines. JOURNAL Chembiochem 10:2295-304 (2009) DOI:10.1002/cbic.200900323 REFERENCE PMID:15502343 AUTHORS Parsons JF, Calabrese K, Eisenstein E, Ladner JE TITLE Structure of the phenazine biosynthesis enzyme PhzG. JOURNAL Acta Crystallogr D Biol Crystallogr 60:2110-3 (2004) DOI:10.1107/S0907444904022474 REFERENCE PMID:11591691 AUTHORS Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS TITLE Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1. JOURNAL J Bacteriol 183:6454-65 (2001) DOI:10.1128/JB.183.21.6454-6465.2001 REL_PATHWAY ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis ///