ENTRY ko00380 Pathway NAME Tryptophan metabolism CLASS Metabolism; Amino acid metabolism PATHWAY_MAP ko00380 Tryptophan metabolism MODULE M00037 Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:ko00380] M00038 Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:ko00380] M00370 Glucosinolate biosynthesis, tryptophan => glucobrassicin [PATH:ko00380] M00912 NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:ko00380] M00936 Melatonin biosynthesis, plants, tryptophan => serotonin => melatonin [PATH:ko00380] DBLINKS GO: 0006568 0009851 ORTHOLOGY K00453 tryptophan 2,3-dioxygenase [EC:1.13.11.11] K00463 indoleamine 2,3-dioxygenase [EC:1.13.11.52] K01432 arylformamidase [EC:3.5.1.9] K14263 kynurenine formamidase [EC:3.5.1.9] K07130 arylformamidase [EC:3.5.1.9] K00486 kynurenine 3-monooxygenase [EC:1.14.13.9] K01556 kynureninase [EC:3.7.1.3] K16901 anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9] K16902 FAD reductase [NAD(P)H] [EC:1.5.1.45] K00452 3-hydroxyanthranilate 3,4-dioxygenase [EC:1.13.11.6] K03392 aminocarboxymuconate-semialdehyde decarboxylase [EC:4.1.1.45] K23234 aminomuconate-semialdehyde dehydrogenase [EC:1.2.1.32] K10217 aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.32 1.2.1.85] K15067 2-aminomuconate deaminase [EC:3.5.99.5] K15791 2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-] K00658 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] K00382 dihydrolipoyl dehydrogenase [EC:1.8.1.4] K00252 glutaryl-CoA dehydrogenase [EC:1.3.8.6] K01692 enoyl-CoA hydratase [EC:4.2.1.17] K01825 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8] K01782 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] K07515 enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211] K07514 enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8] K07511 enoyl-CoA hydratase [EC:4.2.1.17] K00022 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] K00816 kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64] K00825 kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39] K14264 kynurenine aminotransferase [EC:2.6.1.7] K01667 tryptophanase [EC:4.1.99.1] K00502 tryptophan 5-monooxygenase [EC:1.14.16.4] K01593 aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105] K22433 L-tryptophan decarboxylase [EC:4.1.1.105] K24541 tryptamine 5-hydroxylase [EC:1.14.14.186] K00274 monoamine oxidase [EC:1.4.3.4] K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] K14085 aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] K00149 aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3] K00157 aldehyde oxidase [EC:1.2.3.1] K00543 acetylserotonin O-methyltransferase [EC:2.1.1.4] K00669 arylalkylamine N-acetyltransferase [EC:2.3.1.87] K22450 aralkylamine N-acetyltransferase [EC:2.3.1.87] K22588 acetylserotonin O-methyltransferase, plant [EC:2.1.1.4] K13066 caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase [EC:2.1.1.68 2.1.1.4] K07408 cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1] K07409 cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1] K07410 cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1] K14338 cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4] K00562 methyltransferase [EC:2.1.1.49 2.1.1.96] K11812 tryptophan N-monooxygenase [EC:1.14.14.156] K11813 tryptophan N-monooxygenase [EC:1.14.14.156] K11816 indole-3-pyruvate monooxygenase [EC:1.14.13.168] K03334 L-amino-acid oxidase [EC:1.4.3.2] K14265 tryptophan aminotransferase [EC:2.6.1.27] K00838 aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5] K16903 L-tryptophan---pyruvate aminotransferase [EC:2.6.1.99] K00837 aromatic aminotransferase [EC:2.6.1.-] K23109 aromatic 2-oxoacid reductase [EC:1.1.1.110] K04103 indolepyruvate decarboxylase [EC:4.1.1.74] K11182 diamine oxidase [EC:1.4.3.22] K11868 indoleacetaldoxime dehydratase [EC:4.8.1.3] K11817 indole-3-acetaldehyde oxidase [EC:1.2.3.7] K22417 benzaldehyde dehydrogenase (NAD+) / indole-3-acetaldehyde oxidase [EC:1.2.1.28 1.2.3.7] K01501 nitrilase [EC:3.5.5.1] K01721 nitrile hydratase subunit alpha [EC:4.2.1.84] K20807 nitrile hydratase subunit beta [EC:4.2.1.84] K00466 tryptophan 2-monooxygenase [EC:1.13.12.3] K01426 amidase [EC:3.5.1.4] K21801 indoleacetamide hydrolase [EC:3.5.1.-] K11818 aromatic aldoxime N-monooxygenase [EC:1.14.14.45] K11819 S-alkyl-thiohydroximate lyase SUR1 [EC:4.4.1.-] K11820 N-hydroxythioamide S-beta-glucosyltransferase [EC:2.4.1.195] K11821 aromatic desulfoglucosinolate sulfotransferase [EC:2.8.2.24] K01237 myrosinase [EC:3.2.1.147] K03781 catalase [EC:1.11.1.6] K03782 catalase-peroxidase [EC:1.11.1.21] K20219 o-aminophenol oxidase [EC:1.10.3.4] K20204 grixazone synthase / o-aminophenol oxidase [EC:1.10.3.15 1.10.3.4] K23947 2-oxoglutarate-dependent dioxygenase [EC:1.14.11.-] K23384 indoleacetate decarboxylase [EC:4.1.1.115] COMPOUND C00024 Acetyl-CoA C00078 L-Tryptophan C00108 Anthranilate C00322 2-Oxoadipate C00328 L-Kynurenine C00331 Indolepyruvate C00332 Acetoacetyl-CoA C00398 Tryptamine C00463 Indole C00527 Glutaryl-CoA C00632 3-Hydroxyanthranilate C00637 Indole-3-acetaldehyde C00643 5-Hydroxy-L-tryptophan C00780 Serotonin C00877 Crotonoyl-CoA C00954 Indole-3-acetate C00955 Indole-3-ethanol C00978 N-Acetylserotonin C01111 7,8-Dihydroxykynurenate C01144 (S)-3-Hydroxybutanoyl-CoA C01249 7,8-Dihydro-7,8-dihydroxykynurenate C01252 4-(2-Aminophenyl)-2,4-dioxobutanoate C01598 Melatonin C01717 4-Hydroxy-2-quinolinecarboxylic acid C01987 2-Aminophenol C02161 2-Aminophenoxazin-3-one C02172 N-Acetylisatin C02220 2-Aminomuconate C02298 N-Acetylindoxyl C02470 Xanthurenic acid C02693 (Indol-3-yl)acetamide C02700 L-Formylkynurenine C02775 2,3-Dihydroxyindole C02937 Indole-3-acetaldehyde oxime C02938 3-Indoleacetonitrile C03227 3-Hydroxy-L-kynurenine C03230 (Indol-3-yl)glycolaldehyde C03453 gamma-Oxalocrotonate C03574 2-Formylaminobenzaldehyde C03722 Quinolinate C03824 2-Aminomuconate semialdehyde C04409 2-Amino-3-carboxymuconate semialdehyde C05634 5-Hydroxyindoleacetaldehyde C05635 5-Hydroxyindoleacetate C05636 3-Hydroxykynurenamine C05637 4,8-Dihydroxyquinoline C05638 5-Hydroxykynurenamine C05639 4,6-Dihydroxyquinoline C05640 Cinnavalininate C05641 5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate C05642 Formyl-N-acetyl-5-methoxykynurenamine C05643 6-Hydroxymelatonin C05644 3-Methylindolepyruvate C05645 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate C05646 5-Hydroxyindolepyruvate C05647 Formyl-5-hydroxykynurenamine C05648 5-Hydroxy-N-formylkynurenine C05651 5-Hydroxykynurenine C05652 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate C05653 Formylanthranilate C05654 5-(2'-Formylethyl)-4,6-dihydroxypicolinate C05655 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate C05656 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate C05658 Indoxyl C05659 5-Methoxytryptamine C05660 5-Methoxyindoleacetate C05663 6-Hydroxykynurenate C05830 8-Methoxykynurenate C05831 3-Methoxyanthranilate C05832 5-Hydroxyindoleacetylglycine C05834 3-Methyldioxyindole C05835 2-Formaminobenzoylacetate C05837 Glucobrassicin C06212 N-Methylserotonin C06213 N-Methyltryptamine C08313 Skatole C10164 Picolinic acid C16516 Indolylmethylthiohydroximate C16517 Indolylmethyl-desulfoglucosinolate C16518 S-(Indolylmethylthiohydroximoyl)-L-cysteine C17203 N-Hydroxyl-tryptamine C22006 (R)-(Indol-3-yl)lactate C22202 2-Oxoindole-3-acetate REFERENCE PMID:15749753 AUTHORS Woodward AW, Bartel B TITLE Auxin: regulation, action, and interaction. JOURNAL Ann Bot 95:707-35 (2005) DOI:10.1093/aob/mci083 REL_PATHWAY ko00010 Glycolysis / Gluconeogenesis ko00362 Benzoate degradation ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis ko00627 Aminobenzoate degradation ko00760 Nicotinate and nicotinamide metabolism ///