ENTRY ko00380 Pathway NAME Tryptophan metabolism CLASS Metabolism; Amino acid metabolism PATHWAY_MAP ko00380 Tryptophan metabolism MODULE M00037 Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:ko00380] M00038 Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:ko00380] M00370 Glucosinolate biosynthesis, tryptophan => glucobrassicin [PATH:ko00380] M00912 NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:ko00380] M00936 Melatonin biosynthesis, plants, tryptophan => serotonin => melatonin [PATH:ko00380] DBLINKS GO: 0006568 0009851 ORTHOLOGY K00022 HADH; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] K00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] K00149 ALDH9A1; aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3] K00157 AOX; aldehyde oxidase [EC:1.2.3.1] K00252 GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6] K00274 MAO, aofH; monoamine oxidase [EC:1.4.3.4] K00382 DLD, lpd, pdhD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] K00452 HAAO; 3-hydroxyanthranilate 3,4-dioxygenase [EC:1.13.11.6] K00453 TDO2, kynA; tryptophan 2,3-dioxygenase [EC:1.13.11.11] K00463 IDO, INDO; indoleamine 2,3-dioxygenase [EC:1.13.11.52] K00466 iaaM; tryptophan 2-monooxygenase [EC:1.13.12.3] K00486 KMO, BNA4; kynurenine 3-monooxygenase [EC:1.14.13.9] K00502 TPH1_2; tryptophan 5-monooxygenase [EC:1.14.16.4] K00543 ASMT; acetylserotonin O-methyltransferase [EC:2.1.1.4] K00562 INMT, TEMT; methyltransferase [EC:2.1.1.49 2.1.1.96] K00626 ACAT, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] K00658 DLST, sucB; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] K00669 AANAT; arylalkylamine N-acetyltransferase [EC:2.3.1.87] K00816 CCBL; kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64] K00825 AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39] K00837 ISS1, VAS1; aromatic aminotransferase K00838 ARO8; aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5] K01237 E3.2.1.147; myrosinase [EC:3.2.1.147] K01426 E3.5.1.4, amiE; amidase [EC:3.5.1.4] K01432 AFMID; arylformamidase [EC:3.5.1.9] K01501 E3.5.5.1; nitrilase [EC:3.5.5.1] K01556 KYNU; kynureninase [EC:3.7.1.3] K01593 DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105] K01667 tnaA; tryptophanase [EC:4.1.99.1] K01692 paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17] K01721 nthA; nitrile hydratase subunit alpha [EC:4.2.1.84] K01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] K01825 fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8] K03334 IL4I1; L-amino-acid oxidase [EC:1.4.3.2] K03392 ACMSD; aminocarboxymuconate-semialdehyde decarboxylase [EC:4.1.1.45] K03781 katE, CAT, catB, srpA; catalase [EC:1.11.1.6] K03782 katG; catalase-peroxidase [EC:1.11.1.21] K04103 ipdC; indolepyruvate decarboxylase [EC:4.1.1.74] K07130 kynB; arylformamidase [EC:3.5.1.9] K07408 CYP1A1; cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1] K07409 CYP1A2; cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1] K07410 CYP1B1; cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1] K07511 ECHS1; enoyl-CoA hydratase [EC:4.2.1.17] K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8] K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211] K10217 dmpC, xylG, praB; aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.32 1.2.1.85] K11182 AOC1, ABP1; diamine oxidase [EC:1.4.3.22] K11812 CYP79B1_2; tryptophan N-monooxygenase [EC:1.14.14.156] K11813 CYP79B3; tryptophan N-monooxygenase [EC:1.14.14.156] K11816 YUCCA; indole-3-pyruvate monooxygenase [EC:1.14.13.168] K11817 AAO1_2; indole-3-acetaldehyde oxidase [EC:1.2.3.7] K11818 CYP83B1; aromatic aldoxime N-monooxygenase [EC:1.14.14.45] K11819 SUR1, RTY; S-alkyl-thiohydroximate lyase SUR1 [EC:4.4.1.-] K11820 UGT74B1; N-hydroxythioamide S-beta-glucosyltransferase [EC:2.4.1.195] K11821 ST5A, SOT16; aromatic desulfoglucosinolate sulfotransferase [EC:2.8.2.24] K11868 CYP71A13; indoleacetaldoxime dehydratase [EC:4.8.1.3] K13066 COMT; caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase [EC:2.1.1.68 2.1.1.4] K14085 ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] K14263 BNA7; kynurenine formamidase [EC:3.5.1.9] K14264 BNA3; kynurenine aminotransferase [EC:2.6.1.7] K14265 Tam1; tryptophan aminotransferase [EC:2.6.1.27] K14338 cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4] K15067 amnD; 2-aminomuconate deaminase [EC:3.5.99.5] K15791 DHKTD1; 2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-] K16901 K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9] K16902 E1.5.1.45; FAD reductase [NAD(P)H] [EC:1.5.1.45] K16903 TAA1; L-tryptophan---pyruvate aminotransferase [EC:2.6.1.99] K20204 griF; grixazone synthase / o-aminophenol oxidase [EC:1.10.3.15 1.10.3.4] K20219 phsA; o-aminophenol oxidase [EC:1.10.3.4] K20807 nthB; nitrile hydratase subunit beta [EC:4.2.1.84] K21801 iaaH; indoleacetamide hydrolase [EC:3.5.1.-] K22417 AAO4; benzaldehyde dehydrogenase (NAD+) / indole-3-acetaldehyde oxidase [EC:1.2.1.28 1.2.3.7] K22433 PSID; L-tryptophan decarboxylase [EC:4.1.1.105] K22450 SNAT; aralkylamine N-acetyltransferase [EC:2.3.1.87] K22588 ASMT; acetylserotonin O-methyltransferase, plant [EC:2.1.1.4] K23109 fldH; aromatic 2-oxoacid reductase K23234 ALDH8A1; aminomuconate-semialdehyde dehydrogenase K23384 iad; indoleacetate decarboxylase K23947 DAO; 2-oxoglutarate-dependent dioxygenase K24541 CYP71P1; tryptamine 5-hydroxylase K28345 tdiA; didemethylasterriquinone D synthase K28781 E1.4.1.19; tryptophan dehydrogenase COMPOUND C00024 Acetyl-CoA C00078 L-Tryptophan C00108 Anthranilate C00322 2-Oxoadipate C00328 L-Kynurenine C00331 Indolepyruvate C00332 Acetoacetyl-CoA C00398 Tryptamine C00463 Indole C00527 Glutaryl-CoA C00632 3-Hydroxyanthranilate C00637 Indole-3-acetaldehyde C00643 5-Hydroxy-L-tryptophan C00780 Serotonin C00877 Crotonoyl-CoA C00954 Indole-3-acetate C00955 Indole-3-ethanol C00978 N-Acetylserotonin C01111 7,8-Dihydroxykynurenate C01144 (S)-3-Hydroxybutanoyl-CoA C01249 7,8-Dihydro-7,8-dihydroxykynurenate C01252 4-(2-Aminophenyl)-2,4-dioxobutanoate C01598 Melatonin C01717 4-Hydroxy-2-quinolinecarboxylic acid C01987 2-Aminophenol C02161 2-Aminophenoxazin-3-one C02172 N-Acetylisatin C02220 2-Aminomuconate C02298 N-Acetylindoxyl C02470 Xanthurenic acid C02693 (Indol-3-yl)acetamide C02700 L-Formylkynurenine C02775 2,3-Dihydroxyindole C02937 Indole-3-acetaldehyde oxime C02938 3-Indoleacetonitrile C03227 3-Hydroxy-L-kynurenine C03230 (Indol-3-yl)glycolaldehyde C03453 gamma-Oxalocrotonate C03574 2-Formylaminobenzaldehyde C03722 Quinolinate C03824 2-Aminomuconate semialdehyde C04409 2-Amino-3-carboxymuconate semialdehyde C05634 5-Hydroxyindoleacetaldehyde C05635 5-Hydroxyindoleacetate C05636 3-Hydroxykynurenamine C05637 4,8-Dihydroxyquinoline C05638 5-Hydroxykynurenamine C05639 4,6-Dihydroxyquinoline C05640 Cinnavalininate C05641 5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate C05642 Formyl-N-acetyl-5-methoxykynurenamine C05643 6-Hydroxymelatonin C05644 3-Methylindolepyruvate C05645 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate C05646 5-Hydroxyindolepyruvate C05647 Formyl-5-hydroxykynurenamine C05648 5-Hydroxy-N-formylkynurenine C05651 5-Hydroxykynurenine C05652 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate C05653 Formylanthranilate C05654 5-(2'-Formylethyl)-4,6-dihydroxypicolinate C05655 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate C05656 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate C05658 Indoxyl C05659 5-Methoxytryptamine C05660 5-Methoxyindoleacetate C05663 6-Hydroxykynurenate C05830 8-Methoxykynurenate C05831 3-Methoxyanthranilate C05832 5-Hydroxyindoleacetylglycine C05834 3-Methyldioxyindole C05835 2-Formaminobenzoylacetate C05837 Glucobrassicin C06212 N-Methylserotonin C06213 N-Methyltryptamine C08313 Skatole C10164 Picolinic acid C16516 Indolylmethylthiohydroximate C16517 Indolylmethyl-desulfoglucosinolate C16518 S-(Indolylmethylthiohydroximoyl)-L-cysteine C17203 N-Hydroxyl-tryptamine C22006 (R)-(Indol-3-yl)lactate C22202 2-Oxoindole-3-acetate C23064 Didemethylasterriquinone D REFERENCE PMID:15749753 AUTHORS Woodward AW, Bartel B TITLE Auxin: regulation, action, and interaction. JOURNAL Ann Bot 95:707-35 (2005) DOI:10.1093/aob/mci083 REL_PATHWAY ko00010 Glycolysis / Gluconeogenesis ko00362 Benzoate degradation ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis ko00627 Aminobenzoate degradation ko00760 Nicotinate and nicotinamide metabolism ///