ENTRY ko00330 Pathway NAME Arginine and proline metabolism CLASS Metabolism; Amino acid metabolism PATHWAY_MAP ko00330 Arginine and proline metabolism MODULE M00015 Proline biosynthesis, glutamate => proline [PATH:ko00330] M00047 Creatine pathway [PATH:ko00330] M00133 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:ko00330] M00134 Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:ko00330] M00135 GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:ko00330] M00136 GABA biosynthesis, prokaryotes, putrescine => GABA [PATH:ko00330] M00879 Arginine succinyltransferase pathway, arginine => glutamate [PATH:ko00330] M00970 Proline degradation, proline => glutamate [PATH:ko00330] M00972 Proline metabolism [PATH:ko00330] DBLINKS GO: 0006525 0006560 ORTHOLOGY K00613 glycine amidinotransferase [EC:2.1.4.1] K00542 guanidinoacetate N-methyltransferase [EC:2.1.1.2] K00933 creatine kinase [EC:2.7.3.2] K27382 creatine kinase M-type [EC:2.7.3.2] K01470 creatinine amidohydrolase [EC:3.5.2.10] K01485 cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21] K03365 cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21] K01473 N-methylhydantoinase A [EC:3.5.2.14] K01474 N-methylhydantoinase B [EC:3.5.2.14] K08687 N-carbamoylsarcosine amidase [EC:3.5.1.59] K08688 creatinase [EC:3.5.3.3] K01583 arginine decarboxylase [EC:4.1.1.19] K01584 arginine decarboxylase [EC:4.1.1.19] K01585 arginine decarboxylase [EC:4.1.1.19] K02626 arginine decarboxylase [EC:4.1.1.19] K01480 agmatinase [EC:3.5.3.11] K10536 agmatine deiminase [EC:3.5.3.12] K12251 N-carbamoylputrescine amidase [EC:3.5.1.53] K14329 agmatine coumaroyltransferase [EC:2.3.1.64 2.3.1.-] K27502 carboxyaminopropylagmatine dehydrogenase [EC:1.5.1.55] K27684 carboxyaminopropylagmatine decarboxylase [EC:4.1.1.127] K27683 N1-aminopropylagmatine ureohydrolase [EC:3.5.3.24] K01581 ornithine decarboxylase [EC:4.1.1.17] K00797 spermidine synthase [EC:2.5.1.16] K24034 spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming) [EC:2.5.1.16 1.5.1.10] K00802 spermine synthase [EC:2.5.1.22] K01611 S-adenosylmethionine decarboxylase [EC:4.1.1.50] K13746 carboxynorspermidine synthase [EC:1.5.1.43] K13747 carboxynorspermidine decarboxylase [EC:4.1.1.96] K11182 diamine oxidase [EC:1.4.3.22] K09251 putrescine aminotransferase [EC:2.6.1.82] K12256 putrescine---pyruvate transaminase [EC:2.6.1.113] K03343 putrescine oxidase [EC:1.4.3.10] K12259 spermine oxidase [EC:1.5.3.16 1.5.3.-] K13366 polyamine oxidase [EC:1.5.3.14 1.5.3.16 1.5.3.-] K17839 polyamine oxidase [EC:1.5.3.17 1.5.3.-] K13367 polyamine oxidase [EC:1.5.3.17] K00316 spermidine dehydrogenase [EC:1.5.99.6] K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] K14085 aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] K00149 aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3] K00137 aminobutyraldehyde dehydrogenase [EC:1.2.1.19] K12254 4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase [EC:1.2.1.54 1.2.1.-] K05604 beta-Ala-His dipeptidase [EC:3.4.13.20] K08660 cytosolic nonspecific dipeptidase [EC:3.4.13.18] K14755 carnosine synthase [EC:6.3.2.11] K00657 diamine N-acetyltransferase [EC:2.3.1.57] K00274 monoamine oxidase [EC:1.4.3.4] K12252 arginine:pyruvate transaminase [EC:2.6.1.84] K21639 L-arginine oxidase [EC:1.4.3.25] K12253 5-guanidino-2-oxopentanoate decarboxylase [EC:4.1.1.75] K12255 guanidinobutyrase [EC:3.5.3.7] K25365 guanidinobutyrase / D-arginase [EC:3.5.3.7 3.5.3.10] K27001 taurocyamine/4-guanidinobutanoate/3-guanidinopropanoate hydrolase [EC:3.5.3.- 3.5.3.7 3.5.3.17] K01426 amidase [EC:3.5.1.4] K00673 arginine N-succinyltransferase [EC:2.3.1.109] K01484 succinylarginine dihydrolase [EC:3.5.3.23] K00840 succinylornithine aminotransferase [EC:2.6.1.81] K06447 succinylglutamic semialdehyde dehydrogenase [EC:1.2.1.71] K05526 succinylglutamate desuccinylase [EC:3.5.1.96] K09470 gamma-glutamylputrescine synthase [EC:6.3.1.11] K09471 gamma-glutamylputrescine oxidase [EC:1.4.3.-] K09472 4-(gamma-glutamylamino)butanal dehydrogenase [EC:1.2.1.99] K09473 gamma-glutamyl-gamma-aminobutyrate hydrolase [EC:3.5.1.94] K23233 D-octopine dehydrogenase [EC:1.5.1.11] K00296 D-nopaline dehydrogenase [EC:1.5.1.19] K24952 nopaline oxidase subunit A K24953 nopaline oxidase subunit B K24954 octopine oxidase subunit A K24955 octopine oxidase subunit B K00934 arginine kinase [EC:2.7.3.3] K13240 nitric-oxide synthase, brain [EC:1.14.13.39] K13241 nitric-oxide synthase, inducible [EC:1.14.13.39] K13242 nitric-oxide synthase, endothelial [EC:1.14.13.39] K13427 nitric-oxide synthase, plant [EC:1.14.13.39] K00491 nitric-oxide synthase, bacterial [EC:1.14.14.47] K27542 arginine dihydrolase [EC:3.5.3.27] K27545 arginine dihydrolase [EC:3.5.3.27] K01476 arginase [EC:3.5.3.1] K00819 ornithine--oxo-acid transaminase [EC:2.6.1.13] K00286 pyrroline-5-carboxylate reductase [EC:1.5.1.2] K00318 proline dehydrogenase [EC:1.5.5.2] K13821 RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88] K01750 ornithine cyclodeaminase [EC:4.3.1.12] K00294 1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88] K00931 glutamate 5-kinase [EC:2.7.2.11] K00147 glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] K12657 delta-1-pyrroline-5-carboxylate synthetase [EC:2.7.2.11 1.2.1.41] K22842 L-glutamate-5-semialdehyde N-acetyltransferase [EC:2.3.1.271] K01259 proline iminopeptidase [EC:3.4.11.5] K11142 cytosol aminopeptidase [EC:3.4.11.1 3.4.11.5] K00472 prolyl 4-hydroxylase [EC:1.14.11.2] K23121 trans-4-hydroxy-L-proline dehydratase [EC:4.2.1.172] K11394 hydroxyproline dehydrogenase [EC:1.5.5.3] K14454 aspartate aminotransferase, cytoplasmic [EC:2.6.1.1] K14455 aspartate aminotransferase, mitochondrial [EC:2.6.1.1] K00811 aspartate aminotransferase, chloroplastic [EC:2.6.1.1] K00812 aspartate aminotransferase [EC:2.6.1.1] K00813 aspartate aminotransferase [EC:2.6.1.1] K11358 aspartate aminotransferase [EC:2.6.1.1] K00824 D-alanine transaminase [EC:2.6.1.21] K18123 4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16] K01777 proline racemase [EC:5.1.1.4] K21672 2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26] K10793 D-proline reductase (dithiol) PrdA [EC:1.21.4.1] K10794 D-proline reductase (dithiol) PrdB [EC:1.21.4.1] K00273 D-amino-acid oxidase [EC:1.4.3.3] K17851 D-proline dehydrogenase [EC:1.5.99.13] K18384 trans-L-3-hydroxyproline dehydratase [EC:4.2.1.77] K22548 trans-L-3-hydroxyproline dehydratase [EC:4.2.1.77] K21624 cis-L-3-hydroxyproline dehydratase [EC:4.2.1.171] K09123 cis-L-3-hydroxyproline dehydratase [EC:4.2.1.171] K19743 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1] K19742 1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49] COMPOUND C00012 Peptide C00019 S-Adenosyl-L-methionine C00022 Pyruvate C00025 L-Glutamate C00048 Glyoxylate C00062 L-Arginine C00077 L-Ornithine C00086 Urea C00134 Putrescine C00148 L-Proline C00179 Agmatine C00213 Sarcosine C00223 p-Coumaroyl-CoA C00300 Creatine C00315 Spermidine C00334 4-Aminobutanoate C00406 Feruloyl-CoA C00431 5-Aminopentanoate C00436 N-Carbamoylputrescine C00441 L-Aspartate 4-semialdehyde C00533 Nitric oxide C00555 4-Aminobutyraldehyde C00581 Guanidinoacetate C00750 Spermine C00763 D-Proline C00791 Creatinine C00884 Homocarnosine C00986 1,3-Diaminopropane C01035 4-Guanidinobutanoate C01043 N-Carbamoylsarcosine C01110 5-Amino-2-oxopentanoic acid C01137 S-Adenosylmethioninamine C01157 Hydroxyproline C01165 L-Glutamate 5-semialdehyde C01250 N-Acetyl-L-glutamate 5-semialdehyde C01682 Nopaline C02305 Phosphocreatine C02565 N-Methylhydantoin C02647 4-Guanidinobutanal C02714 N-Acetylputrescine C02946 4-Acetamidobutanoate C03078 4-Guanidinobutanamide C03166 Phosphoguanidinoacetate C03287 L-Glutamyl 5-phosphate C03296 N2-Succinyl-L-arginine C03375 Norspermidine C03415 N2-Succinyl-L-ornithine C03564 1-Pyrroline-2-carboxylate C03771 5-Guanidino-2-oxopentanoate C03912 (S)-1-Pyrroline-5-carboxylate C04137 Octopine C04281 L-1-Pyrroline-3-hydroxy-5-carboxylate C05147 trans-3-Hydroxy-L-proline C05931 N-Succinyl-L-glutamate C05932 N-Succinyl-L-glutamate 5-semialdehyde C05933 N(omega)-Hydroxyarginine C05936 N4-Acetylaminobutanal C05938 L-4-Hydroxyglutamate semialdehyde C05945 L-Arginine phosphate C05946 (4R)-4-Hydroxy-2-oxoglutarate C05947 L-erythro-4-Hydroxyglutamate C10497 Feruloylputrescine C15699 gamma-L-Glutamylputrescine C15700 gamma-Glutamyl-gamma-aminobutyraldehyde C15767 4-(L-gamma-Glutamylamino)butanoate C18172 Carboxyspermidine C18174 Carboxynorspermidine C18326 p-Coumaroylputrescine C19706 cis-3-Hydroxy-L-proline C20560 N1-(3-Aminopropyl)agmatine C22886 N1-[(S)-3-amino-3-carboxypropyl]agmatine REFERENCE PMID:5288244 AUTHORS Haake P, Allen GW. TITLE Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase). JOURNAL Proc Natl Acad Sci U S A 68:2691-3 (1971) DOI:10.1073/pnas.68.11.2691 REFERENCE PMID:16499623 AUTHORS Kurihara S, Oda S, Kumagai H, Suzuki H. TITLE Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12. JOURNAL FEMS Microbiol Lett 256:318-23 (2006) DOI:10.1111/j.1574-6968.2006.00137.x REFERENCE PMID:15590624 AUTHORS Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H. TITLE A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. JOURNAL J Biol Chem 280:4602-8 (2005) DOI:10.1074/jbc.M411114200 REL_PATHWAY ko00020 Citrate cycle (TCA cycle) ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00260 Glycine, serine and threonine metabolism ko00270 Cysteine and methionine metabolism ko00310 Lysine degradation ko00410 beta-Alanine metabolism ko00470 D-Amino acid metabolism ko00480 Glutathione metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko00650 Butanoate metabolism ko00770 Pantothenate and CoA biosynthesis ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis ///