ENTRY ko00310 Pathway NAME Lysine degradation CLASS Metabolism; Amino acid metabolism PATHWAY_MAP ko00310 Lysine degradation MODULE M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:ko00310] M00956 Lysine degradation, bacteria, L-lysine => succinate [PATH:ko00310] M00957 Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA [PATH:ko00310] M00960 Lysine degradation, bacteria, L-lysine => D-lysine => succinate [PATH:ko00310] DBLINKS GO: 0006554 ORTHOLOGY K00290 saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7] K14157 alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9] K00293 saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10] K24034 spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming) [EC:2.5.1.16 1.5.1.10] K14085 aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] K26061 L-aminoadipate-semialdehyde dehydrogenase K26062 2-aminoadipate transaminase [EC:2.6.1.39] K00825 kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39] K15791 2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-] K00658 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] K00382 dihydrolipoyl dehydrogenase [EC:1.8.1.4] K00252 glutaryl-CoA dehydrogenase [EC:1.3.8.6] K01692 enoyl-CoA hydratase [EC:4.2.1.17] K01825 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8] K01782 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] K07515 enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211] K07514 enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8] K07511 enoyl-CoA hydratase [EC:4.2.1.17] K00022 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] K18201 hydroxylysine kinase [EC:2.7.1.81] K18202 5-phosphonooxy-L-lysine phospho-lyase [EC:4.2.3.134] K00468 lysine 2-monooxygenase [EC:1.13.12.2] K01506 5-aminopentanamidase [EC:3.5.1.30] K25316 amino-acid racemase [EC:5.1.1.10] K25317 amino-acid racemase [EC:5.1.1.10] K01582 lysine decarboxylase [EC:4.1.1.18] K23385 D-ornithine/D-lysine decarboxylase [EC:4.1.1.116] K09251 putrescine aminotransferase [EC:2.6.1.82] K00137 aminobutyraldehyde dehydrogenase [EC:1.2.1.19] K14268 5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.48 2.6.1.19] K07250 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48] K00135 succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] K15737 glutarate dioxygenase [EC:1.14.11.64] K15736 (S)-2-hydroxyglutarate dehydrogenase [EC:1.1.5.13] K25986 2-oxoadipate dioxygenase/decarboxylase [EC:1.13.11.93] K26063 (R)-2-hydroxyglutarate dehydrogenase [EC:1.1.-.-] K01041 glutaryl-CoA transferase [EC:2.8.3.-] K01843 lysine 2,3-aminomutase [EC:5.4.3.2] K01844 beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3] K18011 beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3] K18012 L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11] K18013 3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247] K18014 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14] K01034 acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] K01035 acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] K21672 2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26] K00824 D-alanine transaminase [EC:2.6.1.21] K26064 D-lysine oxidase K13609 delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21] K19743 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1] K00306 sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7] K26065 L-pipecolate oxidase K18854 acetyl-CoA:lysine N6-acetyltransferase [EC:2.3.1.306] K18804 [cytochrome c]-lysine N-methyltransferase [EC:2.1.1.59] K18826 calmodulin-lysine N-methyltransferase [EC:2.1.1.60] K09186 [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354] K09187 [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354] K09188 [histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354] K14959 [histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354] K09189 [histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354] K11422 [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354] K11431 [histone H3]-lysine4 N-methyltransferase [EC:2.1.1.364] K20796 [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354] K06101 [histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354] K11426 [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357] K22748 [histone H3]-lysine4 N-trimethyltransferase ATXR3 [EC:2.1.1.354] K11419 [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355] K11420 [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355] K11421 [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366] K18494 [histone H3]-lysine9 N-trimethyltransferase SETDB2 [EC:2.1.1.355] K11432 [histone H3]-lysine9 N-trimethyltransferase PRDM2 [EC:2.1.1.355] K17451 [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356] K11430 [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] K11433 [histone H3]-lysine36 N-dimethyltransferase SETMAR [EC:2.1.1.357] K15588 [histone H3]-lysine36 N-dimethyltransferase NSD1 [EC:2.1.1.357] K11424 [histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357] K11425 [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase [EC:2.1.1.370 2.1.1.371] K11423 [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359] K23700 [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359] K11427 [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360] K11428 [histone H4]-lysine20 N-methyltransferase SETD8 [EC:2.1.1.361] K20795 [histone H4]-lysine20 N-methyltransferase PRDM6 [EC:2.1.1.361] K11429 [histone H4]-N-methyl-L-lysine20 N-methyltransferase [EC:2.1.1.362] K04462 [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367] K22410 [histone H3]-lysine9 N-methyltransferase [EC:2.1.1.367] K24405 [histone H3]-lysine9 N-dimethyltransferase [EC:2.1.1.368] K24406 [histone H3]-lysine27 N-methyltransferase [EC:2.1.1.369] K24407 [histone H4]-lysine20 N-trimethyltransferase [EC:2.1.1.372] K00474 trimethyllysine dioxygenase [EC:1.14.11.8] K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] K00149 aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3] K00471 gamma-butyrobetaine dioxygenase [EC:1.14.11.1] K00473 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4] K13645 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4] K13646 lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66] K13647 procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate [EC:1.14.11.4] K11703 collagen beta-1,O-galactosyltransferase [EC:2.4.1.50] COMPOUND C00024 Acetyl-CoA C00026 2-Oxoglutarate C00037 Glycine C00042 Succinate C00047 L-Lysine C00068 Thiamin diphosphate C00136 Butanoyl-CoA C00164 Acetoacetate C00322 2-Oxoadipate C00332 Acetoacetyl-CoA C00408 L-Pipecolate C00431 5-Aminopentanoate C00449 N6-(L-1,3-Dicarboxypropyl)-L-lysine C00450 (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate C00487 Carnitine C00489 Glutarate C00527 Glutaryl-CoA C00739 D-Lysine C00877 Crotonoyl-CoA C00956 L-2-Aminoadipate C00990 5-Aminopentanamide C01087 (R)-2-Hydroxyglutarate C01142 (3S)-3,6-Diaminohexanoate C01144 (S)-3-Hydroxybutanoyl-CoA C01149 4-Trimethylammoniobutanal C01181 4-Trimethylammoniobutanoate C01186 (3S,5S)-3,5-Diaminohexanoate C01211 Procollagen 5-hydroxy-L-lysine C01259 (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine C01672 Cadaverine C02188 Protein lysine C02727 N6-Acetyl-L-lysine C03087 5-Acetamidopentanoate C03196 (S)-2-Hydroxyglutarate C03239 6-Amino-2-oxohexanoate C03273 5-Oxopentanoate C03366 5-Phosphooxy-L-lysine C03656 (S)-5-Amino-3-oxohexanoic acid C03793 N6,N6,N6-Trimethyl-L-lysine C04020 D-Lysopine C04076 L-2-Aminoadipate 6-semialdehyde C04092 Delta1-Piperideine-2-carboxylate C04487 5-(D-Galactosyloxy)-L-lysine-procollagen C05161 (2R,5S)-2,5-Diaminohexanoate C05231 L-3-Aminobutyryl-CoA C05544 Protein N6-methyl-L-lysine C05545 Protein N6,N6-dimethyl-L-lysine C05546 Protein N6,N6,N6-trimethyl-L-lysine C05548 6-Acetamido-2-oxohexanoate C05825 2-Amino-5-oxohexanoate C06157 [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine C12455 5-Aminopentanal C15972 Enzyme N6-(lipoyl)lysine C15973 Enzyme N6-(dihydrolipoyl)lysine C16741 L-Hydroxylysine C22667 4-Carboxy-1-hydroxybutyryl-ThPP REFERENCE PMID:11802770 AUTHORS Vaz FM, Wanders RJ. TITLE Carnitine biosynthesis in mammals. JOURNAL Biochem J 361:417-29 (2002) DOI:10.1042/bj3610417 REFERENCE PMID:1682209 AUTHORS Large PJ, Robertson A. TITLE The route of lysine breakdown in Candida tropicalis. JOURNAL FEMS Microbiol Lett 66:209-13 (1991) DOI:10.1111/j.1574-6968.1990.tb03998.x REL_PATHWAY ko00020 Citrate cycle (TCA cycle) ko00300 Lysine biosynthesis ko00311 Penicillin and cephalosporin biosynthesis ko00780 Biotin metabolism ///