ENTRY       ko00290                     Pathway
NAME        Valine, leucine and isoleucine biosynthesis
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP ko00290  Valine, leucine and isoleucine biosynthesis
MODULE      M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ko00290]
            M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ko00290]
            M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:ko00290]
            M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ko00290]
DBLINKS     GO: 0009097 0009098 0009099
ORTHOLOGY   K01754  threonine dehydratase [EC:4.3.1.19]
            K17989  L-serine/L-threonine ammonia-lyase [EC:4.3.1.17 4.3.1.19]
            K09011  (R)-citramalate synthase [EC:2.3.3.21]
            K01702  3-isopropylmalate dehydratase [EC:4.2.1.33]
            K01703  3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]
            K01704  3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]
            K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
            K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
            K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
            K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
            K00053  ketol-acid reductoisomerase [EC:1.1.1.86]
            K01687  dihydroxy-acid dehydratase [EC:4.2.1.9]
            K00826  branched-chain amino acid aminotransferase [EC:2.6.1.42]
            K00263  leucine dehydrogenase [EC:1.4.1.9]
            K00835  valine--pyruvate aminotransferase [EC:2.6.1.66]
            K14260  alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
            K01649  2-isopropylmalate synthase [EC:2.3.3.13]
            K21359  3-isopropylmalate/methylthioalkylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.170]
            K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
COMPOUND    C00022  Pyruvate
            C00024  Acetyl-CoA
            C00109  2-Oxobutanoate
            C00123  L-Leucine
            C00141  3-Methyl-2-oxobutanoic acid
            C00183  L-Valine
            C00188  L-Threonine
            C00233  4-Methyl-2-oxopentanoate
            C00407  L-Isoleucine
            C00671  (S)-3-Methyl-2-oxopentanoic acid
            C02226  2-Methylmaleate
            C02504  alpha-Isopropylmalate
            C02612  (R)-2-Methylmalate
            C02631  2-Isopropylmaleate
            C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
            C04236  (2S)-2-Isopropyl-3-oxosuccinate
            C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
            C04411  (2R,3S)-3-Isopropylmalate
            C06006  (S)-2-Aceto-2-hydroxybutanoate
            C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
            C06010  (S)-2-Acetolactate
            C06032  D-erythro-3-Methylmalate
            C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
REFERENCE   PMID:15292141
  AUTHORS   Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  TITLE     Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  JOURNAL   J Bacteriol 186:5400-9 (2004)
            DOI:10.1128/JB.186.16.5400-5409.2004
REL_PATHWAY ko00260  Glycine, serine and threonine metabolism
            ko00280  Valine, leucine and isoleucine degradation
            ko00620  Pyruvate metabolism
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