ENTRY ko00280 Pathway NAME Valine, leucine and isoleucine degradation CLASS Metabolism; Amino acid metabolism PATHWAY_MAP ko00280 Valine, leucine and isoleucine degradation MODULE M00036 Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:ko00280] M00741 Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:ko00280] DBLINKS GO: 0006550 0006552 0006574 ORTHOLOGY K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] K03334 L-amino-acid oxidase [EC:1.4.3.2] K00271 valine dehydrogenase (NAD+) [EC:1.4.1.23] K00263 leucine dehydrogenase [EC:1.4.1.9] K00166 2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4] K00167 2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4] K11381 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4] K09699 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168] K00382 dihydrolipoyl dehydrogenase [EC:1.8.1.4] K00186 2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7] K00187 2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7] K00189 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1] K00188 2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7] K00248 butyryl-CoA dehydrogenase [EC:1.3.8.1] K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] K00253 isovaleryl-CoA dehydrogenase [EC:1.3.8.4] K11410 short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] K09478 short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] K11538 isobutyryl-CoA dehydrogenase [EC:1.3.99.-] K01692 enoyl-CoA hydratase [EC:4.2.1.17] K01825 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8] K01782 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] K07515 enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211] K07514 enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8] K07511 enoyl-CoA hydratase [EC:4.2.1.17] K00022 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] K08683 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178] K00632 acetyl-CoA acyltransferase [EC:2.3.1.16] K07513 acetyl-CoA acyltransferase 1 [EC:2.3.1.16] K07508 acetyl-CoA acyltransferase 2 [EC:2.3.1.16] K07509 acetyl-CoA acyltransferase [EC:2.3.1.16] K01965 propionyl-CoA carboxylase alpha subunit [EC:6.4.1.3] K01966 propionyl-CoA carboxylase beta subunit [EC:6.4.1.3 2.1.3.15] K11263 acetyl-CoA/propionyl-CoA/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14] K27094 propionyl-CoA/long-chain acyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.3 6.4.1.- 2.1.3.15] K27095 acyl-CoA carboxylase epsilon subunit K18472 acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] K19312 acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] K22568 acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3] K01964 acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] K15036 acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15] K15037 biotin carboxyl carrier protein K05606 methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] K01847 methylmalonyl-CoA mutase [EC:5.4.99.2] K01849 methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2] K01848 methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2] K05605 3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4] K00020 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] K23146 3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase [EC:1.1.1.31 1.1.1.59] K00140 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27] K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] K14085 aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] K00149 aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3] K00157 aldehyde oxidase [EC:1.2.3.1] K18660 malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-] K18661 malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-] K00822 beta-alanine--pyruvate transaminase [EC:2.6.1.18] K07250 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48] K13524 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22] K00827 alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase [EC:2.6.1.44 2.6.1.40] K01968 3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4] K01969 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4] K05607 methylglutaconyl-CoA hydratase [EC:4.2.1.18] K13766 methylglutaconyl-CoA hydratase [EC:4.2.1.18] K01640 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] K01027 3-oxoacid CoA-transferase [EC:2.8.3.5] K01028 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5] K01029 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5] K01907 acetoacetyl-CoA synthetase [EC:6.2.1.16] K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] K01641 hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] COMPOUND C00024 Acetyl-CoA C00068 Thiamin diphosphate C00091 Succinyl-CoA C00100 Propanoyl-CoA C00123 L-Leucine C00141 3-Methyl-2-oxobutanoic acid C00164 Acetoacetate C00183 L-Valine C00233 4-Methyl-2-oxopentanoate C00332 Acetoacetyl-CoA C00349 2-Methyl-3-oxopropanoate C00356 (S)-3-Hydroxy-3-methylglutaryl-CoA C00407 L-Isoleucine C00630 2-Methylpropanoyl-CoA C00671 (S)-3-Methyl-2-oxopentanoic acid C00683 (S)-Methylmalonyl-CoA C01205 (R)-3-Amino-2-methylpropanoate C01213 (R)-Methylmalonyl-CoA C02170 Methylmalonate C02939 3-Methylbutanoyl-CoA C03069 3-Methylcrotonyl-CoA C03231 3-Methylglutaconyl-CoA C03284 L-3-Aminoisobutanoate C03344 2-Methylacetoacetyl-CoA C03345 2-Methylbut-2-enoyl-CoA C03460 2-Methylprop-2-enoyl-CoA C04405 (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA C05996 Branched chain fatty acid C05998 3-Hydroxyisovaleryl-CoA C06000 (S)-3-Hydroxyisobutyryl-CoA C06001 (S)-3-Hydroxyisobutyrate C06002 (S)-Methylmalonate semialdehyde C15972 Enzyme N6-(lipoyl)lysine C15973 Enzyme N6-(dihydrolipoyl)lysine C15974 3-Methyl-1-hydroxybutyl-ThPP C15975 [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine C15976 2-Methyl-1-hydroxypropyl-ThPP C15977 [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine C15978 2-Methyl-1-hydroxybutyl-ThPP C15979 [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine C15980 (S)-2-Methylbutanoyl-CoA C20827 3-Hydroxyisovalerate REL_PATHWAY ko00020 Citrate cycle (TCA cycle) ko00240 Pyrimidine metabolism ko00290 Valine, leucine and isoleucine biosynthesis ko00522 Biosynthesis of 12-, 14- and 16-membered macrolides ko00640 Propanoate metabolism ko00900 Terpenoid backbone biosynthesis ko01056 Biosynthesis of type II polyketide backbone ///