ENTRY ko00240 Pathway NAME Pyrimidine metabolism CLASS Metabolism; Nucleotide metabolism PATHWAY_MAP ko00240 Pyrimidine metabolism MODULE M00046 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:ko00240] M00051 De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:ko00240] M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:ko00240] M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ko00240] M00938 Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:ko00240] M00939 Pyrimidine degradation, uracil => 3-hydroxypropanoate [PATH:ko00240] M00968 Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate [PATH:ko00240] DRUG D00323 Flucytosine (JP18/USP/INN) D00391 Trifluridine (JAN/USP/INN) D00488 Pyrimethamine (JAN/USP/INN) D02387 Cycloguanil pamoate (USAN) D02487 Proguanil hydrochloride (JAN/USP) D03034 Azelaic acid (USAN/INN) D03771 Diaveridine (USAN/INN) D08428 Proguanil (INN) D12505 Olorofim (USAN/INN) DBLINKS GO: 0006220 0006213 ORTHOLOGY K11540 carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3] K11541 carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2] K01954 carbamoyl-phosphate synthase [EC:6.3.5.5] K01955 carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] K01956 carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] K00609 aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] K00610 aspartate carbamoyltransferase regulatory subunit K00608 aspartate carbamoyltransferase [EC:2.1.3.2] K01465 dihydroorotase [EC:3.5.2.3] K17828 dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14] K02823 dihydroorotate dehydrogenase electron transfer subunit K00226 dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1] K00254 dihydroorotate dehydrogenase [EC:1.3.5.2] K13421 uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23] K00762 orotate phosphoribosyltransferase [EC:2.4.2.10] K01591 orotidine-5'-phosphate decarboxylase [EC:4.1.1.23] K13800 UMP-CMP kinase [EC:2.7.4.14] K13809 UMP-CMP kinase 2, mitochondrial [EC:2.7.4.14] K09903 uridylate kinase [EC:2.7.4.22] K00940 nucleoside-diphosphate kinase [EC:2.7.4.6] K18533 adenylate/nucleoside-diphosphate kinase [EC:2.7.4.3 2.7.4.6] K01510 apyrase [EC:3.6.1.5] K14641 apyrase [EC:3.6.1.5] K14642 golgi apyrase [EC:3.6.1.5] K12304 soluble calcium-activated nucleotidase 1 [EC:3.6.1.6] K12305 ectonucleoside triphosphate diphosphohydrolase 4 [EC:3.6.1.6] K01511 ectonucleoside triphosphate diphosphohydrolase 5/6 [EC:3.6.1.6] K01513 ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9] K04765 nucleoside triphosphate diphosphatase [EC:3.6.1.9] K25435 putative bifunctional nucleoside triphosphate pyrophosphatase / methyltransferase [EC:3.6.1.- 2.1.1.-] K06287 nucleoside triphosphate pyrophosphatase [EC:3.6.1.-] K07043 UTP pyrophosphatase [EC:3.6.1.-] K27603 uridylate cyclase [EC:4.6.1.26] K01518 bis(5'-nucleosidyl)-tetraphosphatase [EC:3.6.1.17] K26955 bis(5'-nucleosidyl)-tetraphosphatase [EC:3.6.1.17] K01937 CTP synthase [EC:6.3.4.2] K27604 cytidylate cyclase [EC:4.6.1.6] K00945 CMP/dCMP kinase [EC:2.7.4.25] K13799 pantoate ligase / CMP/dCMP kinase [EC:6.3.2.1 2.7.4.25] K08320 (d)CTP diphosphatase [EC:3.6.1.65] K00876 uridine kinase [EC:2.7.1.48] K01081 5'-nucleotidase [EC:3.1.3.5] K19970 5'-nucleotidase [EC:3.1.3.5] K11751 5'-nucleotidase / UDP-sugar diphosphatase [EC:3.1.3.5 3.6.1.45] K03787 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6] K02566 5'-nucleotidase [EC:3.1.3.5] K08693 2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase / 5'-nucleotidase [EC:3.1.4.16 3.1.3.6 3.1.3.5] K08723 pyrimidine 5'-nucleotidase [EC:3.1.3.-] K25434 pyrimidine 5'-nucleotidase [EC:3.1.3.-] K01240 uridine nucleosidase [EC:3.2.2.3] K25589 inosine/uridine nucleosidase [EC:3.2.2.2 3.2.2.3] K00757 uridine phosphorylase [EC:2.4.2.3] K09913 purine/pyrimidine-nucleoside phosphorylase [EC:2.4.2.1 2.4.2.2] K00761 uracil phosphoribosyltransferase [EC:2.4.2.9] K02825 pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] K01119 2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase [EC:3.1.4.16 3.1.3.6] K09769 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16] K16328 pseudouridine kinase [EC:2.7.1.83] K16329 pseudouridylate synthase [EC:4.2.1.70] K16330 pseudouridylate synthase / pseudouridine kinase [EC:4.2.1.70 2.7.1.83] K24242 7-methylguanosine nucleotidase [EC:3.1.3.91] K10213 ribosylpyrimidine nucleosidase [EC:3.2.2.8] K01250 pyrimidine-specific ribonucleoside hydrolase [EC:3.2.2.-] K12700 non-specific riboncleoside hydrolase [EC:3.2.2.-] K00756 pyrimidine-nucleoside phosphorylase [EC:2.4.2.2] K21057 cytidine kinase [EC:2.7.1.213] K22026 nucleoside kinase [EC:2.7.1.73 2.7.1.213 2.7.1.-] K06966 pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-] K18931 AMP phosphorylase [EC:2.4.2.57] K01489 cytidine deaminase [EC:3.5.4.5] K01485 cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21] K03365 cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21] K00527 ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2] K00524 ribonucleotide reductase, class II [EC:1.17.4.2] K21636 ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] K01494 dCTP deaminase [EC:3.5.4.13] K00525 ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] K00526 ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] K10807 ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] K10808 ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] K16904 dCTP diphosphatase [EC:3.6.1.12] K09887 dCTP deaminase (dUMP-forming) [EC:3.5.4.30] K07023 5'-deoxynucleotidase [EC:3.1.3.89] K08722 5'-deoxynucleotidase [EC:3.1.3.89] K06952 5'-nucleotidase [EC:3.1.3.89] K00893 deoxycitidine/deoxyadenosine/deoxyguanosine kinase [EC:2.7.1.74 2.7.1.76 2.7.1.113] K15519 deoxyadenosine/deoxycytidine kinase [EC:2.7.1.76 2.7.1.74] K05961 deoxynucleoside kinase [EC:2.7.1.145] K01493 dCMP deaminase [EC:3.5.4.12] K19796 Straboviridae dCMP hydroxymethylase [EC:2.1.2.8] K19797 Straboviridae T-even-induced deoxynucleotide kinase [EC:2.7.4.12] K00943 dTMP kinase [EC:2.7.4.9] K01520 dUTP diphosphatase [EC:3.6.1.23] K00758 thymidine phosphorylase [EC:2.4.2.4] K00857 thymidine kinase [EC:2.7.1.21] K00560 thymidylate synthase [EC:2.1.1.45] K13998 dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45] K03465 thymidylate synthase (FAD) [EC:2.1.1.148] K24670 2',3'-cyclic-nucleotide 2'-phosphodiesterase / phosphoenolpyruvate phosphatase [EC:3.1.4.16 3.1.3.60] K17722 dihydropyrimidine dehydrogenase (NAD+) subunit PreT [EC:1.3.1.1] K17723 dihydropyrimidine dehydrogenase (NAD+) subunit PreA [EC:1.3.1.1] K00207 dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2] K01464 dihydropyrimidinase [EC:3.5.2.2] K01431 beta-ureidopropionase [EC:3.5.1.6] K06016 beta-ureidopropionase / N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87] K19794 barbiturase [EC:3.5.2.1] K19795 ureidomalonase [EC:3.5.1.95] K09018 pyrimidine oxygenase [EC:1.14.99.46] K09024 flavin reductase [EC:1.5.1.-] K09020 ureidoacrylate peracid hydrolase [EC:3.5.1.110] K09021 aminoacrylate peracid reductase K09023 aminoacrylate hydrolase [EC:3.5.1.-] K16066 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-] K09019 3-hydroxypropanoate dehydrogenase [EC:1.1.1.-] COMPOUND C00015 UDP C00039 DNA C00046 RNA C00055 CMP C00063 CTP C00064 L-Glutamine C00075 UTP C00086 Urea C00099 beta-Alanine C00105 UMP C00106 Uracil C00112 CDP C00119 5-Phospho-alpha-D-ribose 1-diphosphate C00169 Carbamoyl phosphate C00178 Thymine C00214 Thymidine C00222 3-Oxopropanoate C00239 dCMP C00295 Orotate C00299 Uridine C00337 (S)-Dihydroorotate C00363 dTDP C00364 dTMP C00365 dUMP C00380 Cytosine C00383 Malonate C00429 5,6-Dihydrouracil C00438 N-Carbamoyl-L-aspartate C00458 dCTP C00459 dTTP C00460 dUTP C00475 Cytidine C00526 Deoxyuridine C00672 2-Deoxy-D-ribose 1-phosphate C00705 dCDP C00813 Barbiturate C00881 Deoxycytidine C00941 3',5'-Cyclic CMP C01013 3-Hydroxypropanoate C01103 Orotidine 5'-phosphate C01168 Pseudouridine 5'-phosphate C01205 (R)-3-Amino-2-methylpropanoate C01346 dUDP C01368 3'-UMP C01563 Carbamate C02067 Pseudouridine C02170 Methylmalonate C02354 2',3'-Cyclic CMP C02355 2',3'-Cyclic UMP C02376 5-Methylcytosine C02642 3-Ureidopropionate C03997 5-Hydroxymethyldeoxycytidylate C05281 5-Methylbarbiturate C05822 3'-CMP C06198 P1,P4-Bis(5'-uridyl) tetraphosphate C11038 2'-Deoxy-5-hydroxymethylcytidine-5'-diphosphate C11039 2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate C15607 3-Oxo-3-ureidopropanoate C20231 (Z)-3-Ureidoacrylate peracid C20249 (Z)-3-Peroxyaminoacrylate C20253 Aminoacrylate C20254 Ureidoacrylate C20846 3-Oxo-3-ureidoisobutyrate C21028 (R)-5,6-Dihydrothymine C21029 (R)-3-Ureidoisobutyrate C22509 3',5'-Cyclic UMP REL_PATHWAY ko00030 Pentose phosphate pathway ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00280 Valine, leucine and isoleucine degradation ko00410 beta-Alanine metabolism ///