ENTRY ko00240 Pathway NAME Pyrimidine metabolism CLASS Metabolism; Nucleotide metabolism PATHWAY_MAP ko00240 Pyrimidine metabolism MODULE M00046 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:ko00240] M00051 De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:ko00240] M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:ko00240] M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ko00240] M00938 Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:ko00240] M00939 Pyrimidine degradation, uracil => 3-hydroxypropanoate [PATH:ko00240] M00968 Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate [PATH:ko00240] DRUG D00323 Flucytosine (JP19/USP/INN) D00391 Trifluridine (JAN/USP/INN) D00488 Pyrimethamine (JAN/USP/INN) D02387 Cycloguanil pamoate (USAN) D02487 Proguanil hydrochloride (JAN/USP) D03034 Azelaic acid (USAN/INN) D03771 Diaveridine (USAN/INN) D08428 Proguanil (INN) D12505 Olorofim (JAN/USAN/INN) DBLINKS GO: 0006220 0006213 ORTHOLOGY K00207 DPYD; dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2] K00226 pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1] K00254 DHODH, pyrD; dihydroorotate dehydrogenase [EC:1.3.5.2] K00524 nrdJ; ribonucleotide reductase, class II [EC:1.17.4.2] K00525 E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] K00526 E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] K00527 rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2] K00560 thyA, TYMS; thymidylate synthase [EC:2.1.1.45] K00608 pyrBI; aspartate carbamoyltransferase [EC:2.1.3.2] K00609 pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] K00610 pyrI; aspartate carbamoyltransferase regulatory subunit K00756 pdp; pyrimidine-nucleoside phosphorylase [EC:2.4.2.2] K00757 udp, UPP; uridine phosphorylase [EC:2.4.2.3] K00758 deoA, TYMP; thymidine phosphorylase [EC:2.4.2.4] K00761 upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9] K00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] K00857 tdk, TK; thymidine kinase [EC:2.7.1.21] K00876 udk, UCK; uridine kinase [EC:2.7.1.48] K00893 DCK; deoxycitidine/deoxyadenosine/deoxyguanosine kinase [EC:2.7.1.74 2.7.1.76 2.7.1.113] K00940 ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6] K00943 tmk, DTYMK; dTMP kinase [EC:2.7.4.9] K00945 cmk; CMP/dCMP kinase [EC:2.7.4.25] K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] K01119 cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase [EC:3.1.4.16 3.1.3.6] K01240 URH1; uridine nucleosidase [EC:3.2.2.3] K01250 rihA; pyrimidine-specific ribonucleoside hydrolase [EC:3.2.2.-] K01431 UPB1, pydC; beta-ureidopropionase [EC:3.5.1.6] K01464 DPYS, dht, hydA; dihydropyrimidinase [EC:3.5.2.2] K01465 URA4, pyrC; dihydroorotase [EC:3.5.2.3] K01485 codA; cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21] K01489 cdd, CDA; cytidine deaminase [EC:3.5.4.5] K01493 comEB; dCMP deaminase [EC:3.5.4.12] K01494 dcd; dCTP deaminase [EC:3.5.4.13] K01510 ENTPD1_3_8, CD39; apyrase [EC:3.6.1.5] K01511 ENTPD5_6; ectonucleoside triphosphate diphosphohydrolase 5/6 [EC:3.6.1.6] K01513 ENPP1_3, CD203; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9] K01518 NUDT2; bis(5'-nucleosidyl)-tetraphosphatase [EC:3.6.1.17] K01520 dut; dUTP diphosphatase [EC:3.6.1.23] K01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23] K01937 pyrG, CTPS; CTP synthase [EC:6.3.4.2] K01954 K01954; carbamoyl-phosphate synthase [EC:6.3.5.5] K01955 carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] K01956 carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] K02566 nagD; 5'-nucleotidase [EC:3.1.3.5] K02823 pyrDII; dihydroorotate dehydrogenase electron transfer subunit K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] K03365 FCY1; cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21] K03465 thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6] K04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9] K05961 dnk; deoxynucleoside kinase [EC:2.7.1.145] K06016 pydC; beta-ureidopropionase / N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87] K06287 yhdE; nucleoside triphosphate pyrophosphatase [EC:3.6.1.-] K06952 yfdR; 5'-nucleotidase [EC:3.1.3.89] K06966 ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-] K07023 YGK1, HDDC2; 5'-deoxynucleotidase [EC:3.1.3.89] K07043 upp; UTP pyrophosphatase [EC:3.6.1.-] K08320 nudG; (d)CTP diphosphatase [EC:3.6.1.65] K08693 yfkN; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase / 5'-nucleotidase [EC:3.1.4.16 3.1.3.6 3.1.3.5] K08722 yfbR; 5'-deoxynucleotidase [EC:3.1.3.89] K08723 yjjG; pyrimidine 5'-nucleotidase [EC:3.1.3.-] K09018 rutA; pyrimidine oxygenase [EC:1.14.99.46] K09019 rutE; 3-hydroxypropanoate dehydrogenase [EC:1.1.1.-] K09020 rutB; ureidoacrylate peracid hydrolase [EC:3.5.1.110] K09021 rutC; aminoacrylate peracid reductase K09023 rutD; aminoacrylate hydrolase [EC:3.5.1.-] K09024 rutF; flavin reductase [EC:1.5.1.-] K09769 ymdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16] K09887 dcd; dCTP deaminase (dUMP-forming) [EC:3.5.4.30] K09903 pyrH; uridylate kinase [EC:2.7.4.22] K09913 ppnP; purine/pyrimidine-nucleoside phosphorylase [EC:2.4.2.1 2.4.2.2] K10213 rihB; ribosylpyrimidine nucleosidase [EC:3.2.2.8] K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3] K11541 URA2; carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2] K11751 ushA; 5'-nucleotidase / UDP-sugar diphosphatase [EC:3.1.3.5 3.6.1.45] K12304 CANT1; soluble calcium-activated nucleotidase 1 [EC:3.6.1.6] K12305 ENTPD4, LALP70; ectonucleoside triphosphate diphosphohydrolase 4 [EC:3.6.1.6] K12700 rihC; non-specific riboncleoside hydrolase [EC:3.2.2.-] K13421 UMPS; uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23] K13799 panC-cmk; pantoate ligase / CMP/dCMP kinase [EC:6.3.2.1 2.7.4.25] K13800 CMPK1, UMPK; UMP-CMP kinase [EC:2.7.4.14] K13809 CMPK2; UMP-CMP kinase 2, mitochondrial [EC:2.7.4.14] K13998 DHFR-TS; dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45] K14641 APY; apyrase [EC:3.6.1.5] K14642 YND1; golgi apyrase [EC:3.6.1.5] K15519 dck; deoxyadenosine/deoxycytidine kinase [EC:2.7.1.76 2.7.1.74] K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-] K16328 psuK; pseudouridine kinase [EC:2.7.1.83] K16329 psuG; pseudouridylate synthase [EC:4.2.1.70] K16330 K16330; pseudouridylate synthase / pseudouridine kinase [EC:4.2.1.70 2.7.1.83] K16904 DCTPP1; dCTP diphosphatase [EC:3.6.1.12] K17722 preT; dihydropyrimidine dehydrogenase (NAD+) subunit PreT [EC:1.3.1.1] K17723 preA; dihydropyrimidine dehydrogenase (NAD+) subunit PreA [EC:1.3.1.1] K17828 pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14] K18533 AK9; adenylate/nucleoside-diphosphate kinase [EC:2.7.4.3 2.7.4.6] K18931 deoA; AMP phosphorylase [EC:2.4.2.57] K19794 bar; barbiturase [EC:3.5.2.1] K19795 E3.5.1.95; ureidomalonase [EC:3.5.1.95] K19796 gp42; Straboviridae dCMP hydroxymethylase [EC:2.1.2.8] K19797 gp1; Straboviridae T-even-induced deoxynucleotide kinase [EC:2.7.4.12] K19970 NT5E, CD73; 5'-nucleotidase [EC:3.1.3.5] K21057 E2.7.1.213; cytidine kinase [EC:2.7.1.213] K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] K22026 K22026; nucleoside kinase [EC:2.7.1.73 2.7.1.213 2.7.1.-] K24242 NT5C3; 7-methylguanosine nucleotidase K24670 K24670; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / phosphoenolpyruvate phosphatase K25434 pynA; pyrimidine 5'-nucleotidase K25435 ASMTL; putative bifunctional nucleoside triphosphate pyrophosphatase / methyltransferase K25589 inuH; inosine/uridine nucleosidase K26955 NUDT25, NUDX25; bis(5'-nucleosidyl)-tetraphosphatase K27603 pycC; uridylate cyclase K27604 pycC; cytidylate cyclase K28865 CDADC1; cytidine deaminase COMPOUND C00015 UDP C00039 DNA C00046 RNA C00055 CMP C00063 CTP C00064 L-Glutamine C00075 UTP C00086 Urea C00099 beta-Alanine C00105 UMP C00106 Uracil C00112 CDP C00119 5-Phospho-alpha-D-ribose 1-diphosphate C00169 Carbamoyl phosphate C00178 Thymine C00214 Thymidine C00222 3-Oxopropanoate C00239 dCMP C00295 Orotate C00299 Uridine C00337 (S)-Dihydroorotate C00363 dTDP C00364 dTMP C00365 dUMP C00380 Cytosine C00383 Malonate C00429 5,6-Dihydrouracil C00438 N-Carbamoyl-L-aspartate C00458 dCTP C00459 dTTP C00460 dUTP C00475 Cytidine C00526 Deoxyuridine C00672 2-Deoxy-D-ribose 1-phosphate C00705 dCDP C00813 Barbiturate C00881 Deoxycytidine C00941 3',5'-Cyclic CMP C01013 3-Hydroxypropanoate C01103 Orotidine 5'-phosphate C01168 Pseudouridine 5'-phosphate C01205 (R)-3-Amino-2-methylpropanoate C01346 dUDP C01368 3'-UMP C01563 Carbamate C02067 Pseudouridine C02170 Methylmalonate C02354 2',3'-Cyclic CMP C02355 2',3'-Cyclic UMP C02376 5-Methylcytosine C02642 3-Ureidopropionate C03997 5-Hydroxymethyldeoxycytidylate C05281 5-Methylbarbiturate C05822 3'-CMP C06198 P1,P4-Bis(5'-uridyl) tetraphosphate C11038 2'-Deoxy-5-hydroxymethylcytidine-5'-diphosphate C11039 2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate C15607 3-Oxo-3-ureidopropanoate C20231 (Z)-3-Ureidoacrylate peracid C20249 (Z)-3-Peroxyaminoacrylate C20253 Aminoacrylate C20254 Ureidoacrylate C20846 3-Oxo-3-ureidoisobutyrate C21028 (R)-5,6-Dihydrothymine C21029 (R)-3-Ureidoisobutyrate C22509 3',5'-Cyclic UMP REL_PATHWAY ko00030 Pentose phosphate pathway ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00280 Valine, leucine and isoleucine degradation ko00410 beta-Alanine metabolism ///