ENTRY ko00061 Pathway NAME Fatty acid biosynthesis CLASS Metabolism; Lipid metabolism PATHWAY_MAP ko00061 Fatty acid biosynthesis MODULE M00082 Fatty acid biosynthesis, initiation [PATH:ko00061] M00083 Fatty acid biosynthesis, elongation [PATH:ko00061] M00086 beta-Oxidation, acyl-CoA synthesis [PATH:ko00061] M00873 Fatty acid biosynthesis in mitochondria, animals [PATH:ko00061] M00874 Fatty acid biosynthesis in mitochondria, fungi [PATH:ko00061] DBLINKS GO: 0006633 ORTHOLOGY K11262 acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15] K01946 acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15] K01962 acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] K02160 acetyl-CoA carboxylase biotin carboxyl carrier protein K01961 acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] K01963 acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] K11263 acetyl-CoA/propionyl-CoA/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14] K18472 acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] K18660 malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-] K00645 [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] K00665 fatty acid synthase, animal type [EC:2.3.1.85] K00668 fatty acid synthase subunit beta, fungi type [EC:2.3.1.86] K00667 fatty acid synthase subunit alpha, fungi type [EC:2.3.1.86] K11533 fatty acid synthase, bacteria type [EC:2.3.1.-] K00648 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] K18473 acetoacetyl-[acyl-carrier protein] synthase [EC:2.3.1.180] K00647 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41] K09458 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] K00059 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] K11539 carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-] K13370 17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) / 3-oxoacyl-[acyl-carrier protein] reductase alpha subunit [EC:1.1.1.62 1.1.1.239] K01716 3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14] K02372 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] K16363 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] K22540 3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-] K22541 3-hydroxyacyl-thioester dehydratase, fungi type [EC:4.2.1.-] K00208 enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] K02371 enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9] K10780 enoyl-[acyl-carrier protein] reductase III [EC:1.3.1.104] K00209 enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase (NAD+) [EC:1.3.1.9 1.3.1.44] K07512 mitochondrial enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase [EC:1.3.1.- 1.3.1.38] K18474 trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14] K10781 fatty acyl-ACP thioesterase B [EC:3.1.2.14 3.1.2.21] K01071 medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21] K10782 fatty acyl-ACP thioesterase A [EC:3.1.2.14] K03921 acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26] K03922 acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.-] K01897 long-chain acyl-CoA synthetase [EC:6.2.1.3] K15013 long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3] COMPOUND C00024 Acetyl-CoA C00083 Malonyl-CoA C00154 Palmitoyl-CoA C00173 Acyl-[acyl-carrier protein] C00229 Acyl-carrier protein C00249 Hexadecanoic acid C00383 Malonate C00638 Long-chain fatty acid C00685 3-Oxoacyl-[acyl-carrier protein] C00693 trans-2,3-Dehydroacyl-[acyl-carrier protein] C00712 (9Z)-Octadecenoic acid C01203 Oleoyl-[acyl-carrier protein] C01209 Malonyl-[acyl-carrier protein] C01271 (3R)-3-Hydroxyacyl-[acyl-carrier protein] C01530 Octadecanoic acid C01571 Decanoic acid C02679 Dodecanoic acid C02843 Long-chain acyl-CoA C03939 Acetyl-[acyl-carrier protein] C04088 Octadecanoyl-[acyl-carrier protein] C04180 cis-Dec-3-enoyl-[acp] C04246 But-2-enoyl-[acyl-carrier protein] C04618 (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] C04619 (3R)-3-Hydroxydecanoyl-[acyl-carrier protein] C04620 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] C04633 (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] C04688 (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] C05223 Dodecanoyl-[acyl-carrier protein] C05744 Acetoacetyl-[acp] C05745 Butyryl-[acp] C05746 3-Oxohexanoyl-[acp] C05747 (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein] C05748 trans-Hex-2-enoyl-[acp] C05749 Hexanoyl-[acp] C05750 3-Oxooctanoyl-[acp] C05751 trans-Oct-2-enoyl-[acp] C05752 Octanoyl-[acp] C05753 3-Oxodecanoyl-[acp] C05754 trans-Dec-2-enoyl-[acp] C05755 Decanoyl-[acp] C05756 3-Oxododecanoyl-[acp] C05757 (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein] C05758 trans-Dodec-2-enoyl-[acp] C05759 3-Oxotetradecanoyl-[acp] C05760 trans-Tetradec-2-enoyl-[acp] C05761 Tetradecanoyl-[acp] C05762 3-Oxohexadecanoyl-[acp] C05763 trans-Hexadec-2-enoyl-[acp] C05764 Hexadecanoyl-[acp] C06423 Octanoic acid C06424 Tetradecanoic acid C08362 (9Z)-Hexadecenoic acid C16219 3-Oxostearoyl-[acp] C16220 (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein] C16221 (2E)-Octadecenoyl-[acp] C16520 Hexadecenoyl-[acyl-carrier protein] C20683 Long-chain acyl-[acyl-carrier protein] C20794 n-7 Unsaturated acyl-[acyl-carrier protein] REFERENCE PMID:12061798 AUTHORS Salas JJ, Ohlrogge JB. TITLE Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases. JOURNAL Arch Biochem Biophys 403:25-34 (2002) DOI:10.1016/S0003-9861(02)00017-6 REFERENCE PMID:12518017 AUTHORS Zhang YM, Marrakchi H, White SW, Rock CO. TITLE The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase. JOURNAL J Lipid Res 44:1-10 (2003) DOI:10.1194/jlr.R200016-JLR200 REFERENCE PMID:11337402 AUTHORS Voelker T, Kinney AJ. TITLE VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS. JOURNAL Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001) DOI:10.1146/annurev.arplant.52.1.335 REFERENCE PMID:17573542 AUTHORS Barker GC, Larson TR, Graham IA, Lynn JR, King GJ. TITLE Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome. JOURNAL Plant Physiol 144:1827-42 (2007) DOI:10.1104/pp.107.096172 REFERENCE PMID:30201289 AUTHORS Bowman CE, Wolfgang MJ TITLE Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism. JOURNAL Adv Biol Regul 71:34-40 (2019) DOI:10.1016/j.jbior.2018.09.002 REFERENCE PMID:25203508 AUTHORS Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z TITLE Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. JOURNAL Nat Commun 5:4805 (2014) DOI:10.1038/ncomms5805 REFERENCE PMID:19686777 AUTHORS Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ TITLE Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism. JOURNAL Prog Lipid Res 49:27-45 (2010) DOI:10.1016/j.plipres.2009.08.001 REFERENCE PMID:27553474 AUTHORS Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK TITLE Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology. JOURNAL Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017) DOI:10.1016/j.bbalip.2016.08.011 REL_PATHWAY ko00020 Citrate cycle (TCA cycle) ko00062 Fatty acid elongation ko00071 Fatty acid degradation ko00074 Mycolic acid biosynthesis ko00410 beta-Alanine metabolism ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko00620 Pyruvate metabolism ko00785 Lipoic acid metabolism ///