ENTRY 3101 CDS T01001 SYMBOL HK3, HKIII, HXK3 NAME (RefSeq) hexokinase 3 ORTHOLOGY K00844 hexokinase [EC:2.7.1.1] ORGANISM hsa Homo sapiens (human) PATHWAY hsa00010 Glycolysis / Gluconeogenesis hsa00051 Fructose and mannose metabolism hsa00052 Galactose metabolism hsa00500 Starch and sucrose metabolism hsa00520 Amino sugar and nucleotide sugar metabolism hsa00524 Neomycin, kanamycin and gentamicin biosynthesis hsa01100 Metabolic pathways hsa01200 Carbon metabolism hsa01250 Biosynthesis of nucleotide sugars hsa04066 HIF-1 signaling pathway hsa04910 Insulin signaling pathway hsa04930 Type II diabetes mellitus hsa04973 Carbohydrate digestion and absorption hsa05131 Shigellosis hsa05230 Central carbon metabolism in cancer MODULE hsa_M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate hsa_M00549 Nucleotide sugar biosynthesis, glucose => UDP-glucose hsa_M00892 UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc NETWORK nt06524 Apoptosis ELEMENT N00950 Shigella FimA to crosstalk between extrinsic and intrinsic apoptotic pathways DRUG_TARGET Lonidamine: D07257 BRITE KEGG Orthology (KO) [BR:hsa00001] 09100 Metabolism 09101 Carbohydrate metabolism 00010 Glycolysis / Gluconeogenesis 3101 (HK3) 00051 Fructose and mannose metabolism 3101 (HK3) 00052 Galactose metabolism 3101 (HK3) 00500 Starch and sucrose metabolism 3101 (HK3) 00520 Amino sugar and nucleotide sugar metabolism 3101 (HK3) 09110 Biosynthesis of other secondary metabolites 00524 Neomycin, kanamycin and gentamicin biosynthesis 3101 (HK3) 09130 Environmental Information Processing 09132 Signal transduction 04066 HIF-1 signaling pathway 3101 (HK3) 09150 Organismal Systems 09154 Digestive system 04973 Carbohydrate digestion and absorption 3101 (HK3) 09160 Human Diseases 09161 Cancer: overview 05230 Central carbon metabolism in cancer 3101 (HK3) 09171 Infectious disease: bacterial 05131 Shigellosis 3101 (HK3) 09167 Endocrine and metabolic disease 04930 Type II diabetes mellitus 3101 (HK3) 09180 Brite Hierarchies 09182 Protein families: genetic information processing 04131 Membrane trafficking [BR:hsa04131] 3101 (HK3) Enzymes [BR:hsa01000] 2. Transferases 2.7 Transferring phosphorus-containing groups 2.7.1 Phosphotransferases with an alcohol group as acceptor 2.7.1.1 hexokinase 3101 (HK3) Membrane trafficking [BR:hsa04131] Autophagy Mitophagy Other mitophagy associated proteins 3101 (HK3) POSITION 5:complement(176880869..176899346) MOTIF Pfam: Hexokinase_2 Hexokinase_1 DUF5473 DBLINKS NCBI-GeneID: 3101 NCBI-ProteinID: NP_002106 OMIM: 142570 HGNC: 4925 Ensembl: ENSG00000160883 UniProt: P52790 STRUCTURE PDB AASEQ 923 MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQ ALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEP RSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRST LISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVG LVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLN PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPST GAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQ VAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHR RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA LDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAI VNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGD DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ RLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLC GAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE DGSGKGAALVTAVACRLAQLTRV NTSEQ 2772 atggactccattgggtcttcagggttgcggcagggggaagaaaccctgagttgctctgag gagggcttgcccgggccctcagacagctcagagctggtgcaggagtgcctgcagcagttc aaggtgacaagggcacagctacagcagatccaagccagcctcttgggttccatggagcag gcgctgaggggacaggccagccctgcccctgcggtccggatgctgcctacatacgtgggg tccaccccacatggcactgagcaaggagacttcgtggtgctggagctgggggccacaggg gcctcactgcgtgttttgtgggtgactctaactggcattgaggggcatagggtggagccc agaagccaggagtttgtgatcccccaagaggtgatgctgggtgctggccagcagctcttt gactttgctgcccactgcctgtctgagttcctggatgcgcagcctgtgaacaaacagggt ctgcagcttggcttcagcttctctttcccttgtcaccagacgggcttggacaggagcacc ctcatttcctggaccaaaggttttaggtgcagtggtgtggaaggccaggatgtggtccag ctgctgagagatgccattcggaggcagggggcctacaacatcgacgtggttgctgtggtg aacgacacagtgggcaccatgatgggctgtgagccgggggtcaggccgtgtgaggttggg ctagttgtagacacgggcaccaacgcgtgttacatggaggaggcacggcatgtggcagtg ctggacgaagaccggggccgcgtctgcgtcagcgtcgagtggggctccttcagcgatgat ggggcgctgggaccagtgctgaccaccttcgaccataccctggaccatgagtccctgaat cctggtgctcagaggtttgagaagatgatcggaggcctgtacctgggtgagctggtgcgg ctggtgctggctcacttggcccggtgtggggtcctctttggtggctgcacctcccctgcc ctgctgagccaaggcagcatcctcctggaacacgtggctgagatggaggacccctctact ggggcagcccgtgtccatgctatcctgcaggacttgggcctgagccctggggcttcggat gttgagcttgtgcagcacgtctgtgcggccgtgtgcacgcgggctgcccagctctgtgct gccgccctggccgctgttctctcctgcctccagcacagccgggagcaacaaacactccag gttgctgtggccaccggaggccgagtgtgtgagcggcaccccaggttctgcagcgtcctg caggggacagtgatgctcctggccccggaatgcgatgtctccttaatcccctctgtggat ggtggtggccggggagtggcgatggtgactgccgtggctgcccgtctggctgcccaccgg cgcctgctggaggagaccctggccccattccggttgaaccatgatcaactggctgcggtt caggcacagatgcggaaggccatggccaaggggctccgaggggaggcctcctcccttcgc atgctgcccactttcgtccgggccacccctgacggcagcgagcgaggggatttcctggcc ctggacctcgggggcacgaacttccgtgtcctcctggtacgtgtgaccacaggcgtgcag atcaccagcgagatctactccattcccgagactgtggcccagggttctgggcagcagctc tttgaccacatcgtggactgcatcgtggacttccagcagaagcagggcctgagcgggcag agcctcccactgggttttaccttctccttcccatgtaggcagcttggcctagaccagggc atcctcctgaactggaccaagggtttcaaggcatcagactgcgagggccaagatgtcgtg agtctgttgcgggaagccatcactcgcagacaggcagtggagctgaatgtggttgccatt gtcaatgacacggtggggaccatgatgtcctgtggctatgaggacccccgttgcgagata ggcctcattgtcggaaccggcaccaatgcctgctacatggaggagctccggaatgtggcg ggcgtgcctggggactcaggccgcatgtgcatcaacatggagtggggcgcctttggggac gatggctctctggccatgctcagcacccgctttgatgcaagtgtggaccaggcgtccatc aaccccggcaagcagaggtttgaaaagatgatcagcggcatgtacctgggggagatcgtc cgccacatccttttacatttaaccagccttggcgttctcttccggggccagcagatccag cgccttcagaccagggacatcttcaagaccaagttcctctctgagatcgaaagtgacagc ctggccctgcggcaggtccgagccatcctagaggatctggggctacccctgacctcagat gacgccctgatggtgctagaggtgtgccaggctgtgtcccagagggctgcccagctctgt ggggcgggtgtagctgccgtggtggagaagatccgggagaaccggggcctggaagagctg gcagtgtctgtgggggtggatggaacgctctacaagctgcacccgcgcttctccagcctg gtggcggccacagtgcgggagctggcccctcgctgtgtggtcacgttcctgcagtcagag gatgggtccggcaaaggtgcggccctggtcaccgctgttgcctgccgccttgcgcagttg actcgtgtctga ///