ENTRY 10000 CDS T01001 SYMBOL AKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2 NAME (RefSeq) AKT serine/threonine kinase 3 ORTHOLOGY K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] ORGANISM hsa Homo sapiens (human) PATHWAY hsa01521 EGFR tyrosine kinase inhibitor resistance hsa01522 Endocrine resistance hsa01524 Platinum drug resistance hsa04010 MAPK signaling pathway hsa04012 ErbB signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04066 HIF-1 signaling pathway hsa04068 FoxO signaling pathway hsa04071 Sphingolipid signaling pathway hsa04072 Phospholipase D signaling pathway hsa04140 Autophagy - animal hsa04150 mTOR signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04210 Apoptosis hsa04211 Longevity regulating pathway hsa04213 Longevity regulating pathway - multiple species hsa04218 Cellular senescence hsa04261 Adrenergic signaling in cardiomyocytes hsa04370 VEGF signaling pathway hsa04371 Apelin signaling pathway hsa04380 Osteoclast differentiation hsa04510 Focal adhesion hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04611 Platelet activation hsa04613 Neutrophil extracellular trap formation hsa04620 Toll-like receptor signaling pathway hsa04625 C-type lectin receptor signaling pathway hsa04630 JAK-STAT signaling pathway hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04664 Fc epsilon RI signaling pathway hsa04666 Fc gamma R-mediated phagocytosis hsa04668 TNF signaling pathway hsa04722 Neurotrophin signaling pathway hsa04725 Cholinergic synapse hsa04728 Dopaminergic synapse hsa04810 Regulation of actin cytoskeleton hsa04910 Insulin signaling pathway hsa04914 Progesterone-mediated oocyte maturation hsa04915 Estrogen signaling pathway hsa04917 Prolactin signaling pathway hsa04919 Thyroid hormone signaling pathway hsa04920 Adipocytokine signaling pathway hsa04922 Glucagon signaling pathway hsa04923 Regulation of lipolysis in adipocytes hsa04926 Relaxin signaling pathway hsa04929 GnRH secretion hsa04931 Insulin resistance hsa04932 Non-alcoholic fatty liver disease hsa04933 AGE-RAGE signaling pathway in diabetic complications hsa04935 Growth hormone synthesis, secretion and action hsa04936 Alcoholic liver disease hsa04973 Carbohydrate digestion and absorption hsa05010 Alzheimer disease hsa05017 Spinocerebellar ataxia hsa05131 Shigellosis hsa05132 Salmonella infection hsa05135 Yersinia infection hsa05142 Chagas disease hsa05145 Toxoplasmosis hsa05152 Tuberculosis hsa05160 Hepatitis C hsa05161 Hepatitis B hsa05162 Measles hsa05163 Human cytomegalovirus infection hsa05164 Influenza A hsa05165 Human papillomavirus infection hsa05166 Human T-cell leukemia virus 1 infection hsa05167 Kaposi sarcoma-associated herpesvirus infection hsa05168 Herpes simplex virus 1 infection hsa05169 Epstein-Barr virus infection hsa05170 Human immunodeficiency virus 1 infection hsa05200 Pathways in cancer hsa05205 Proteoglycans in cancer hsa05207 Chemical carcinogenesis - receptor activation hsa05208 Chemical carcinogenesis - reactive oxygen species hsa05210 Colorectal cancer hsa05211 Renal cell carcinoma hsa05212 Pancreatic cancer hsa05213 Endometrial cancer hsa05214 Glioma hsa05215 Prostate cancer hsa05218 Melanoma hsa05220 Chronic myeloid leukemia hsa05221 Acute myeloid leukemia hsa05222 Small cell lung cancer hsa05223 Non-small cell lung cancer hsa05224 Breast cancer hsa05225 Hepatocellular carcinoma hsa05226 Gastric cancer hsa05230 Central carbon metabolism in cancer hsa05231 Choline metabolism in cancer hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05415 Diabetic cardiomyopathy hsa05417 Lipid and atherosclerosis hsa05418 Fluid shear stress and atherosclerosis NETWORK nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06161 Human immunodeficiency virus 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06166 Human papillomavirus (HPV) nt06167 Human cytomegalovirus (HCMV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06170 Influenza A virus (IAV) nt06214 PI3K signaling (cancer) nt06224 CXCR signaling (cancer) nt06260 Colorectal cancer nt06261 Gastric cancer nt06262 Pancreatic cancer nt06263 Hepatocellular carcinoma nt06264 Renal cell carcinoma nt06266 Non-small cell lung cancer nt06267 Small cell lung cancer nt06268 Melanoma nt06270 Breast cancer nt06271 Endometrial cancer nt06272 Prostate cancer nt06273 Glioma nt06275 Acute myeloid leukemia nt06276 Chronic myeloid leukemia nt06462 Spinocerebellar ataxia nt06464 Amyotrophic lateral sclerosis nt06530 PI3K signaling nt06537 TCR/BCR signaling ELEMENT N00030 EGF-EGFR-RAS-PI3K signaling pathway N00031 Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway N00032 Mutation-activated KRAS/NRAS to PI3K signaling pathway N00033 EGF-EGFR-PI3K signaling pathway N00034 ERBB2-overexpression to PI3K signaling pathway N00035 Amplified EGFR to PI3K signaling pathway N00036 Mutation-activated EGFR to PI3K signaling pathway N00037 FGF-FGFR-PI3K signaling pathway N00038 Amplified FGFR to PI3K signaling pathway N00039 PDGF-PDGFR-PI3K signaling pathway N00040 Amplified PDGFR to PI3K signaling pathway N00042 EGFR-overexpression to PI3K signaling pathway N00043 HGF-MET-PI3K signaling pathway N00044 Mutation-activated MET to PI3K signaling pathway N00045 KITLG-KIT-PI3K signaling pathway N00046 Mutation-activated KIT to PI3K signaling pathway N00047 EML4-ALK fusion kinase to PI3K signaling pathway N00048 BCR-ABL fusion kinase to PI3K signaling pathway N00049 Mutation-activated PI3K to PI3K signaling pathway N00050 Amplified PI3K to PI3K signaling pathway N00051 Deleted PTEN to PI3K signaling pathway N00052 Mutation-inactivated PTEN to PI3K signaling pathway N00082 Loss of NKX3-1 to PI3K signaling pathway N00154 CXCR-GNB/G-PI3K-AKT signaling pathway N00182 IGF-IGFR-PI3K-NFKB signaling pathway N00218 FLT3LG-FLT3-RAS-PI3K signaling pathway N00220 PTEN-PIP3-AKT signaling pathway N00231 TGFA-EGFR-PI3K signaling pathway N00232 TGFA-overexpression to PI3K signaling pathway N00234 IGF2-IGF1R-PI3K signaling pathway N00236 IGF2-overexpression to PI3K signaling pathway N00238 IGF1R-overexpression to PI3K signaling pathway N00247 HGF-overexpression to PI3K signaling pathway N00249 MET-overexpression to PI3K signaling pathway N00253 Amplified ERBB2 to PI3K signaling pathway N00260 Amplified MET to PI3K signaling pathway N00281 EGF-overexpression to PI3K signaling pathway N00282 EREG-EGFR-PI3K signaling pathway N00283 EREG-overexpression to PI3K signaling pathway N00284 AREG-EGFR-PI3K signaling pathway N00285 AREG-overexpression to PI3K signaling pathway N00342 MAGI-PTEN signaling pathway N00355 PP2A-AKT signaling pathway N00390 EGF-EGFR-PI3K-NFKB signaling pathway N00399 CCR2-GNB/G-PI3K-NFKB signaling pathway N00430 CXCR4-GNAI-PI3K-BAD signaling pathway N00514 Mutation-activated EGFR to PI3K signaling pathway N00582 IGF-IGF1R-PI3K signaling pathway N00683 CD80/CD86-CD28-PI3K signaling pathway N00963 RELN-VLDLR-PI3K signaling pathway N00964 DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway N01063 Mutation-activated MET to PI3K signaling pathway N01065 Mutation-activated RET to PI3K signaling pathway N01163 NRG-ERBB4-PI3K signaling pathway N01338 ACH-CHRN-PI3K signaling pathway N01339 NNK/NNN to PI3K signaling pathway N01347 EP/NE-ADRB-PI3K signaling pathway N01348 Nicotine/NNK to PI3K signaling pathway N01349 ACH-CHRN-PI3K signaling pathway N01350 NNK/NNN to PI3K signaling pathway N01355 Arsenic to PI3K signaling pathway N01356 Membrane-initiated progesterone signaling pathway N01357 P4/MPA to membrane-initiated progesterone signaling pathway N01358 P4-PR-PI3K signaling pathway N01359 P4/MPA to PR-PI3K signaling pathway N01409 Metals to PI3K signaling pathway N01579 CD80/CD86-CTLA4-PP2A signaling pathway N01656 GF-RTK-PI3K signaling pathway N01657 GPCR-PI3K signaling pathway N01658 GF-RTK-RAS-PI3K signaling pathway N01695 BCR-BCAP/CD19-PI3K signaling pathway N01696 ICOSLG/ICOS-PI3K signaling pathway DISEASE H01885 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome DRUG_TARGET Afuresertib (DG01408): D10381 D10382 Capivasertib: D11371 Ipatasertib (DG02851): D10641 D11074 Miransertib (DG03026): D11409 D11508 Triciribine phosphate: D06221 Uprosertib: D10674 BRITE KEGG Orthology (KO) [BR:hsa00001] 09130 Environmental Information Processing 09132 Signal transduction 04010 MAPK signaling pathway 10000 (AKT3) 04012 ErbB signaling pathway 10000 (AKT3) 04014 Ras signaling pathway 10000 (AKT3) 04015 Rap1 signaling pathway 10000 (AKT3) 04370 VEGF signaling pathway 10000 (AKT3) 04371 Apelin signaling pathway 10000 (AKT3) 04630 JAK-STAT signaling pathway 10000 (AKT3) 04668 TNF signaling pathway 10000 (AKT3) 04066 HIF-1 signaling pathway 10000 (AKT3) 04068 FoxO signaling pathway 10000 (AKT3) 04072 Phospholipase D signaling pathway 10000 (AKT3) 04071 Sphingolipid signaling pathway 10000 (AKT3) 04024 cAMP signaling pathway 10000 (AKT3) 04022 cGMP-PKG signaling pathway 10000 (AKT3) 04151 PI3K-Akt signaling pathway 10000 (AKT3) 04152 AMPK signaling pathway 10000 (AKT3) 04150 mTOR signaling pathway 10000 (AKT3) 09140 Cellular Processes 09141 Transport and catabolism 04140 Autophagy - animal 10000 (AKT3) 09143 Cell growth and death 04210 Apoptosis 10000 (AKT3) 04218 Cellular senescence 10000 (AKT3) 09144 Cellular community - eukaryotes 04510 Focal adhesion 10000 (AKT3) 04550 Signaling pathways regulating pluripotency of stem cells 10000 (AKT3) 09142 Cell motility 04810 Regulation of actin cytoskeleton 10000 (AKT3) 09150 Organismal Systems 09151 Immune system 04611 Platelet activation 10000 (AKT3) 04613 Neutrophil extracellular trap formation 10000 (AKT3) 04620 Toll-like receptor signaling pathway 10000 (AKT3) 04625 C-type lectin receptor signaling pathway 10000 (AKT3) 04660 T cell receptor signaling pathway 10000 (AKT3) 04662 B cell receptor signaling pathway 10000 (AKT3) 04664 Fc epsilon RI signaling pathway 10000 (AKT3) 04666 Fc gamma R-mediated phagocytosis 10000 (AKT3) 04062 Chemokine signaling pathway 10000 (AKT3) 09152 Endocrine system 04910 Insulin signaling pathway 10000 (AKT3) 04922 Glucagon signaling pathway 10000 (AKT3) 04923 Regulation of lipolysis in adipocytes 10000 (AKT3) 04920 Adipocytokine signaling pathway 10000 (AKT3) 04929 GnRH secretion 10000 (AKT3) 04915 Estrogen signaling pathway 10000 (AKT3) 04914 Progesterone-mediated oocyte maturation 10000 (AKT3) 04917 Prolactin signaling pathway 10000 (AKT3) 04926 Relaxin signaling pathway 10000 (AKT3) 04935 Growth hormone synthesis, secretion and action 10000 (AKT3) 04919 Thyroid hormone signaling pathway 10000 (AKT3) 09153 Circulatory system 04261 Adrenergic signaling in cardiomyocytes 10000 (AKT3) 09154 Digestive system 04973 Carbohydrate digestion and absorption 10000 (AKT3) 09156 Nervous system 04725 Cholinergic synapse 10000 (AKT3) 04728 Dopaminergic synapse 10000 (AKT3) 04722 Neurotrophin signaling pathway 10000 (AKT3) 09158 Development and regeneration 04380 Osteoclast differentiation 10000 (AKT3) 09149 Aging 04211 Longevity regulating pathway 10000 (AKT3) 04213 Longevity regulating pathway - multiple species 10000 (AKT3) 09160 Human Diseases 09161 Cancer: overview 05200 Pathways in cancer 10000 (AKT3) 05205 Proteoglycans in cancer 10000 (AKT3) 05207 Chemical carcinogenesis - receptor activation 10000 (AKT3) 05208 Chemical carcinogenesis - reactive oxygen species 10000 (AKT3) 05230 Central carbon metabolism in cancer 10000 (AKT3) 05231 Choline metabolism in cancer 10000 (AKT3) 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 10000 (AKT3) 09162 Cancer: specific types 05210 Colorectal cancer 10000 (AKT3) 05212 Pancreatic cancer 10000 (AKT3) 05225 Hepatocellular carcinoma 10000 (AKT3) 05226 Gastric cancer 10000 (AKT3) 05214 Glioma 10000 (AKT3) 05221 Acute myeloid leukemia 10000 (AKT3) 05220 Chronic myeloid leukemia 10000 (AKT3) 05218 Melanoma 10000 (AKT3) 05211 Renal cell carcinoma 10000 (AKT3) 05215 Prostate cancer 10000 (AKT3) 05213 Endometrial cancer 10000 (AKT3) 05224 Breast cancer 10000 (AKT3) 05222 Small cell lung cancer 10000 (AKT3) 05223 Non-small cell lung cancer 10000 (AKT3) 09172 Infectious disease: viral 05166 Human T-cell leukemia virus 1 infection 10000 (AKT3) 05170 Human immunodeficiency virus 1 infection 10000 (AKT3) 05161 Hepatitis B 10000 (AKT3) 05160 Hepatitis C 10000 (AKT3) 05164 Influenza A 10000 (AKT3) 05162 Measles 10000 (AKT3) 05168 Herpes simplex virus 1 infection 10000 (AKT3) 05163 Human cytomegalovirus infection 10000 (AKT3) 05167 Kaposi sarcoma-associated herpesvirus infection 10000 (AKT3) 05169 Epstein-Barr virus infection 10000 (AKT3) 05165 Human papillomavirus infection 10000 (AKT3) 09171 Infectious disease: bacterial 05132 Salmonella infection 10000 (AKT3) 05131 Shigellosis 10000 (AKT3) 05135 Yersinia infection 10000 (AKT3) 05152 Tuberculosis 10000 (AKT3) 09174 Infectious disease: parasitic 05145 Toxoplasmosis 10000 (AKT3) 05142 Chagas disease 10000 (AKT3) 09164 Neurodegenerative disease 05010 Alzheimer disease 10000 (AKT3) 05017 Spinocerebellar ataxia 10000 (AKT3) 09166 Cardiovascular disease 05417 Lipid and atherosclerosis 10000 (AKT3) 05418 Fluid shear stress and atherosclerosis 10000 (AKT3) 05415 Diabetic cardiomyopathy 10000 (AKT3) 09167 Endocrine and metabolic disease 04936 Alcoholic liver disease 10000 (AKT3) 04932 Non-alcoholic fatty liver disease 10000 (AKT3) 04931 Insulin resistance 10000 (AKT3) 04933 AGE-RAGE signaling pathway in diabetic complications 10000 (AKT3) 09176 Drug resistance: antineoplastic 01521 EGFR tyrosine kinase inhibitor resistance 10000 (AKT3) 01524 Platinum drug resistance 10000 (AKT3) 01522 Endocrine resistance 10000 (AKT3) 09180 Brite Hierarchies 09181 Protein families: metabolism 01001 Protein kinases [BR:hsa01001] 10000 (AKT3) Enzymes [BR:hsa01000] 2. Transferases 2.7 Transferring phosphorus-containing groups 2.7.11 Protein-serine/threonine kinases 2.7.11.1 non-specific serine/threonine protein kinase 10000 (AKT3) Protein kinases [BR:hsa01001] Serine/threonine kinases: AGC group AKT/PKB family 10000 (AKT3) POSITION 1:complement(243488233..243851079) MOTIF Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 FTA2 ABC1 PH_11 DBLINKS NCBI-GeneID: 10000 NCBI-ProteinID: NP_005456 OMIM: 611223 HGNC: 393 Ensembl: ENSG00000117020 UniProt: Q9Y243 STRUCTURE PDB AASEQ 479 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE NTSEQ 1440 atgagcgatgttaccattgtgaaagaaggttgggttcagaagaggggagaatatataaaa aactggaggccaagatacttccttttgaagacagatggctcattcataggatataaagag aaacctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag ttaatgaaaacagaacgaccaaagccaaacacatttataatcagatgtctccagtggact actgttatagagagaacatttcatgtagatactccagaggaaagggaagaatggacagaa gctatccaggctgtagcagacagactgcagaggcaagaagaggagagaatgaattgtagt ccaacttcacaaattgataatataggagaggaagagatggatgcctctacaacccatcat aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttggg aaagttattttggttcgagagaaggcaagtggaaaatactatgctatgaagattctgaag aaagaagtcattattgcaaaggatgaagtggcacacactctaactgaaagcagagtatta aagaacactagacatccctttttaacatccttgaaatattccttccagacaaaagaccgt ttgtgttttgtgatggaatatgttaatgggggcgagctgtttttccatttgtcgagagag cgggtgttctctgaggaccgcacacgtttctatggtgcagaaattgtctctgccttggac tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatctaatgctggac aaagatggccacataaaaattacagattttggactttgcaaagaagggatcacagatgca gccaccatgaagacattctgtggcactccagaatatctggcaccagaggtgttagaagat aatgactatggccgagcagtagactggtggggcctaggggttgtcatgtatgaaatgatg tgtgggaggttacctttctacaaccaggaccatgagaaactttttgaattaatattaatg gaagacattaaatttcctcgaacactctcttcagatgcaaaatcattgctttcagggctc ttgataaaggatccaaataaacgccttggtggaggaccagatgatgcaaaagaaattatg agacacagtttcttctctggagtaaactggcaagatgtatatgataaaaagcttgtacct ccttttaaacctcaagtaacatctgagacagatactagatattttgatgaagaatttaca gctcagactattacaataacaccacctgaaaaatatgatgaggatggtatggactgcatg gacaatgagaggcggccgcatttccctcaattttcctactctgcaagtggacgagaataa /// ENTRY 1017 CDS T01001 SYMBOL CDK2, CDKN2, p33(CDK2) NAME (RefSeq) cyclin dependent kinase 2 ORTHOLOGY K02206 cyclin-dependent kinase 2 [EC:2.7.11.22] ORGANISM hsa Homo sapiens (human) PATHWAY hsa04068 FoxO signaling pathway hsa04110 Cell cycle hsa04114 Oocyte meiosis hsa04115 p53 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04218 Cellular senescence hsa04914 Progesterone-mediated oocyte maturation hsa04934 Cushing syndrome hsa05160 Hepatitis C hsa05161 Hepatitis B hsa05162 Measles hsa05165 Human papillomavirus infection hsa05166 Human T-cell leukemia virus 1 infection hsa05169 Epstein-Barr virus infection hsa05200 Pathways in cancer hsa05203 Viral carcinogenesis hsa05215 Prostate cancer hsa05222 Small cell lung cancer hsa05226 Gastric cancer NETWORK nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06162 Hepatitis B virus (HBV) nt06165 Epstein-Barr virus (EBV) nt06166 Human papillomavirus (HPV) nt06230 Cell cycle (cancer) nt06261 Gastric cancer nt06263 Hepatocellular carcinoma nt06267 Small cell lung cancer nt06272 Prostate cancer nt06360 Cushing syndrome nt06509 DNA replication ELEMENT N00091 p27-Cell cycle G1/S N00092 Amplified MYC to p27-cell cycle G1/S N00093 Loss of CDKN1B to p27-cell cycle G1/S N00254 CDKN1B-reduced expression to p27-cell cycle G1/S N00255 Amplified CCNE to cell cycle G1/S N00264 EBV EBNA3C to p27-Cell cycle G1/S N00316 Mutation-inactivated CDKN1B to p27-cell cycle G1/S N00360 HPV E7 to p27-cell cycle G1/S N00482 EBV EBNA3C to p27-Cell cycle G1/S N00497 HTLV-1 Tax to p21-cell cycle G1/S N00498 HTLV-1 Tax to p21-cell cycle G1/S N00536 MDM2-p21-Cell cycle G1/S N00537 HBV HBx to cell cycle G1/S N01468 DNA replication licensing DRUG_TARGET Alvocidib (DG02041): D02880 D09868 Dinaciclib: D09604 Tagtociclib: D12601 Zotiraciclib (DG03058): D11599 D11600 BRITE KEGG Orthology (KO) [BR:hsa00001] 09130 Environmental Information Processing 09132 Signal transduction 04068 FoxO signaling pathway 1017 (CDK2) 04151 PI3K-Akt signaling pathway 1017 (CDK2) 09140 Cellular Processes 09143 Cell growth and death 04110 Cell cycle 1017 (CDK2) 04114 Oocyte meiosis 1017 (CDK2) 04115 p53 signaling pathway 1017 (CDK2) 04218 Cellular senescence 1017 (CDK2) 09150 Organismal Systems 09152 Endocrine system 04914 Progesterone-mediated oocyte maturation 1017 (CDK2) 09160 Human Diseases 09161 Cancer: overview 05200 Pathways in cancer 1017 (CDK2) 05203 Viral carcinogenesis 1017 (CDK2) 09162 Cancer: specific types 05226 Gastric cancer 1017 (CDK2) 05215 Prostate cancer 1017 (CDK2) 05222 Small cell lung cancer 1017 (CDK2) 09172 Infectious disease: viral 05166 Human T-cell leukemia virus 1 infection 1017 (CDK2) 05161 Hepatitis B 1017 (CDK2) 05160 Hepatitis C 1017 (CDK2) 05162 Measles 1017 (CDK2) 05169 Epstein-Barr virus infection 1017 (CDK2) 05165 Human papillomavirus infection 1017 (CDK2) 09167 Endocrine and metabolic disease 04934 Cushing syndrome 1017 (CDK2) 09180 Brite Hierarchies 09181 Protein families: metabolism 01001 Protein kinases [BR:hsa01001] 1017 (CDK2) 09182 Protein families: genetic information processing 03032 DNA replication proteins [BR:hsa03032] 1017 (CDK2) 03036 Chromosome and associated proteins [BR:hsa03036] 1017 (CDK2) Enzymes [BR:hsa01000] 2. Transferases 2.7 Transferring phosphorus-containing groups 2.7.11 Protein-serine/threonine kinases 2.7.11.22 cyclin-dependent kinase 1017 (CDK2) Protein kinases [BR:hsa01001] Serine/threonine kinases: CMGC group CDK family 1017 (CDK2) DNA replication proteins [BR:hsa03032] Eukaryotic type DNA Replication Initiation Factors CDK (cyclin dependent kinase) 1017 (CDK2) Chromosome and associated proteins [BR:hsa03036] Eukaryotic type Centrosome formation proteins Kinases and associated factors 1017 (CDK2) POSITION 12:55966830..55972789 MOTIF Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Haspin_kinase Kinase-like DBLINKS NCBI-GeneID: 1017 NCBI-ProteinID: NP_001789 OMIM: 116953 HGNC: 1771 Ensembl: ENSG00000123374 UniProt: P24941 STRUCTURE PDB AASEQ 298 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL NTSEQ 897 atggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaa gccagaaacaagttgacgggagaggtggtggcgcttaagaaaatccgcctggacactgag actgagggtgtgcccagtactgccatccgagagatctctctgcttaaggagcttaaccat cctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggttttt gaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcct cttcccctcatcaagagctatctgttccagctgctccagggcctagctttctgccattct catcgggtcctccaccgagaccttaaacctcagaatctgcttattaacacagagggggcc atcaagctagcagactttggactagccagagcttttggagtccctgttcgtacttacacc catgaggtggtgaccctgtggtaccgagctcctgaaatcctcctgggctgcaaatattat tccacagctgtggacatctggagcctgggctgcatctttgctgagatggtgactcgccgg gccctattccctggagattctgagattgaccagctcttccggatctttcggactctgggg accccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaagtttc cccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacgg agcttgttatcgcaaatgctgcactacgaccctaacaagcggatttcggccaaggcagcc ctggctcaccctttcttccaggatgtgaccaagccagtaccccatcttcgactctga /// ENTRY 1019 CDS T01001 SYMBOL CDK4, CMM3, PSK-J3 NAME (RefSeq) cyclin dependent kinase 4 ORTHOLOGY K02089 cyclin-dependent kinase 4 [EC:2.7.11.22] ORGANISM hsa Homo sapiens (human) PATHWAY hsa01522 Endocrine resistance hsa04110 Cell cycle hsa04115 p53 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04218 Cellular senescence hsa04530 Tight junction hsa04660 T cell receptor signaling pathway hsa04933 AGE-RAGE signaling pathway in diabetic complications hsa04934 Cushing syndrome hsa05160 Hepatitis C hsa05162 Measles hsa05163 Human cytomegalovirus infection hsa05164 Influenza A hsa05165 Human papillomavirus infection hsa05166 Human T-cell leukemia virus 1 infection hsa05167 Kaposi sarcoma-associated herpesvirus infection hsa05169 Epstein-Barr virus infection hsa05200 Pathways in cancer hsa05203 Viral carcinogenesis hsa05212 Pancreatic cancer hsa05214 Glioma hsa05218 Melanoma hsa05219 Bladder cancer hsa05220 Chronic myeloid leukemia hsa05222 Small cell lung cancer hsa05223 Non-small cell lung cancer hsa05224 Breast cancer hsa05225 Hepatocellular carcinoma NETWORK nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06166 Human papillomavirus (HPV) nt06167 Human cytomegalovirus (HCMV) nt06170 Influenza A virus (IAV) nt06230 Cell cycle (cancer) nt06262 Pancreatic cancer nt06263 Hepatocellular carcinoma nt06265 Bladder cancer nt06266 Non-small cell lung cancer nt06267 Small cell lung cancer nt06268 Melanoma nt06270 Breast cancer nt06273 Glioma nt06276 Chronic myeloid leukemia ELEMENT N00066 MDM2-p21-Cell cycle G1/S N00067 Deleted p14(ARF) to p21-cell cycle G1/S N00068 Amplified MDM2 to p21-cell cycle G1/S N00069 p16-Cell cycle G1/S N00070 Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S N00071 Deleted p16(INK4a) to p16-cell cycle G1/S N00072 Amplified CDK4 to cell cycle G1/S N00073 Mutation-activated CDK4 to cell cycle G1/S N00076 Mutation-inactivated p14(ARF) to p21-cell cycle G1/S N00088 Amplified MYC to p15-cell cycle G1/S N00089 Amplified MYC to cell cycle G1/S N00090 p15-Cell cycle G1/S N00168 KSHV vCyclin to cell cycle G1/S N00275 Amplified CCND1 to cell cycle G1/S N00347 p300-p21-Cell cycle G1/S N00483 EBV EBNA3C to cell cycle G1/S N00529 HCV core to RXRA/PPARA-mediated transcription N00530 HCV core to RXRA/LXRA-mediated transcription DISEASE H00030 Cervical cancer H00038 Melanoma H00042 Glioma DRUG_TARGET Abemaciclib: D10688 Alvocidib (DG02041): D02880 D09868 Atirmociclib: D12834 Lerociclib: D11455 Palbociclib (DG01831): D10372 D10652 Ribociclib (DG02084): D10883 D10979 Trilaciclib (DG03146): D11130 D11987 BRITE KEGG Orthology (KO) [BR:hsa00001] 09130 Environmental Information Processing 09132 Signal transduction 04151 PI3K-Akt signaling pathway 1019 (CDK4) 09140 Cellular Processes 09143 Cell growth and death 04110 Cell cycle 1019 (CDK4) 04115 p53 signaling pathway 1019 (CDK4) 04218 Cellular senescence 1019 (CDK4) 09144 Cellular community - eukaryotes 04530 Tight junction 1019 (CDK4) 09150 Organismal Systems 09151 Immune system 04660 T cell receptor signaling pathway 1019 (CDK4) 09160 Human Diseases 09161 Cancer: overview 05200 Pathways in cancer 1019 (CDK4) 05203 Viral carcinogenesis 1019 (CDK4) 09162 Cancer: specific types 05212 Pancreatic cancer 1019 (CDK4) 05225 Hepatocellular carcinoma 1019 (CDK4) 05214 Glioma 1019 (CDK4) 05220 Chronic myeloid leukemia 1019 (CDK4) 05218 Melanoma 1019 (CDK4) 05219 Bladder cancer 1019 (CDK4) 05224 Breast cancer 1019 (CDK4) 05222 Small cell lung cancer 1019 (CDK4) 05223 Non-small cell lung cancer 1019 (CDK4) 09172 Infectious disease: viral 05166 Human T-cell leukemia virus 1 infection 1019 (CDK4) 05160 Hepatitis C 1019 (CDK4) 05164 Influenza A 1019 (CDK4) 05162 Measles 1019 (CDK4) 05163 Human cytomegalovirus infection 1019 (CDK4) 05167 Kaposi sarcoma-associated herpesvirus infection 1019 (CDK4) 05169 Epstein-Barr virus infection 1019 (CDK4) 05165 Human papillomavirus infection 1019 (CDK4) 09167 Endocrine and metabolic disease 04933 AGE-RAGE signaling pathway in diabetic complications 1019 (CDK4) 04934 Cushing syndrome 1019 (CDK4) 09176 Drug resistance: antineoplastic 01522 Endocrine resistance 1019 (CDK4) 09180 Brite Hierarchies 09181 Protein families: metabolism 01001 Protein kinases [BR:hsa01001] 1019 (CDK4) Enzymes [BR:hsa01000] 2. Transferases 2.7 Transferring phosphorus-containing groups 2.7.11 Protein-serine/threonine kinases 2.7.11.22 cyclin-dependent kinase 1019 (CDK4) Protein kinases [BR:hsa01001] Serine/threonine kinases: CMGC group CDK family 1019 (CDK4) POSITION 12:complement(57747727..57752310) MOTIF Pfam: Pkinase PK_Tyr_Ser-Thr APH Kdo ABC1 Haspin_kinase Kinase-like DBLINKS NCBI-GeneID: 1019 NCBI-ProteinID: NP_000066 OMIM: 123829 HGNC: 1773 Ensembl: ENSG00000135446 UniProt: P11802 STRUCTURE PDB AASEQ 303 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG NPE NTSEQ 912 atggctacctctcgatatgagccagtggctgaaattggtgtcggtgcctatgggacagtg tacaaggcccgtgatccccacagtggccactttgtggccctcaagagtgtgagagtcccc aatggaggaggaggtggaggaggccttcccatcagcacagttcgtgaggtggctttactg aggcgactggaggcttttgagcatcccaatgttgtccggctgatggacgtctgtgccaca tcccgaactgaccgggagatcaaggtaaccctggtgtttgagcatgtagaccaggaccta aggacatatctggacaaggcacccccaccaggcttgccagccgaaacgatcaaggatctg atgcgccagtttctaagaggcctagatttccttcatgccaattgcatcgttcaccgagat ctgaagccagagaacattctggtgacaagtggtggaacagtcaagctggctgactttggc ctggccagaatctacagctaccagatggcacttacacccgtggttgttacactctggtac cgagctcccgaagttcttctgcagtccacatatgcaacacctgtggacatgtggagtgtt ggctgtatctttgcagagatgtttcgtcgaaagcctctcttctgtggaaactctgaagcc gaccagttgggcaaaatctttgacctgattgggctgcctccagaggatgactggcctcga gatgtatccctgccccgtggagcctttccccccagagggccccgcccagtgcagtcggtg gtacctgagatggaggagtcgggagcacagctgctgctggaaatgctgacttttaaccca cacaagcgaatctctgcctttcgagctctgcagcactcttatctacataaggatgaaggt aatccggagtga ///