ENTRY       10                CDS       T01001
SYMBOL      NAT2, AAC2, NAT-2, PNAT
NAME        (RefSeq) N-acetyltransferase 2
ORTHOLOGY   K00622  arylamine N-acetyltransferase [EC:2.3.1.5]
ORGANISM    hsa  Homo sapiens (human)
PATHWAY     hsa00232  Caffeine metabolism
            hsa00983  Drug metabolism - other enzymes
            hsa01100  Metabolic pathways
            hsa05204  Chemical carcinogenesis - DNA adducts
NETWORK     nt06250  DNA adduct formation (cancer)
  ELEMENT   N01370  PhIP to DNA adducts
            N01372  IQ to DNA adducts
            N01373  MeIQx to DNA adducts
BRITE       KEGG Orthology (KO) [BR:hsa00001]
             09100 Metabolism
              09110 Biosynthesis of other secondary metabolites
               00232 Caffeine metabolism
                10 (NAT2)
              09111 Xenobiotics biodegradation and metabolism
               00983 Drug metabolism - other enzymes
                10 (NAT2)
             09160 Human Diseases
              09161 Cancer: overview
               05204 Chemical carcinogenesis - DNA adducts
                10 (NAT2)
            Enzymes [BR:hsa01000]
             2. Transferases
              2.3  Acyltransferases
               2.3.1  Transferring groups other than aminoacyl groups
                2.3.1.5  arylamine N-acetyltransferase
                 10 (NAT2)
POSITION    8:18386301..18401218
MOTIF       Pfam: Acetyltransf_2
DBLINKS     NCBI-GeneID: 10
            NCBI-ProteinID: NP_000006
            OMIM: 612182
            HGNC: 7646
            Ensembl: ENSG00000156006
            UniProt: P11245 A4Z6T7
STRUCTURE   PDB
AASEQ       290
            MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENLNMHCGQAMELGLEAIFDHIV
            RRNRGGWCLQVNQLLYWALTTIGFQTTMLGGYFYIPPVNKYSTGMVHLLLQVTIDGRNYI
            VDAGSGSSSQMWQPLELISGKDQPQVPCIFCLTEERGIWYLDQIRREQYITNKEFLNSHL
            LPKKKHQKIYLFTLEPRTIEDFESMNTYLQTSPTSSFITTSFCSLQTPEGVYCLVGFILT
            YRKFNYKDNTDLVEFKTLTEEEVEEVLRNIFKISLGRNLVPKPGDGSLTI
NTSEQ       873
            atggacattgaagcatattttgaaagaattggctataagaactctaggaacaaattggac
            ttggaaacattaactgacattcttgagcaccagatccgggctgttccctttgagaacctt
            aacatgcattgtgggcaagccatggagttgggcttagaggctatttttgatcacattgta
            agaagaaaccggggtgggtggtgtctccaggtcaatcaacttctgtactgggctctgacc
            acaatcggttttcagaccacaatgttaggagggtatttttacatccctccagttaacaaa
            tacagcactggcatggttcaccttctcctgcaggtgaccattgacggcaggaattacatt
            gtcgatgctgggtctggaagctcctcccagatgtggcagcctctagaattaatttctggg
            aaggatcagcctcaggtgccttgcattttctgcttgacagaagagagaggaatctggtac
            ctggaccaaatcaggagagagcagtatattacaaacaaagaatttcttaattctcatctc
            ctgccaaagaagaaacaccaaaaaatatacttatttacgcttgaacctcgaacaattgaa
            gattttgagtctatgaatacatacctgcagacgtctccaacatcttcatttataaccaca
            tcattttgttccttgcagaccccagaaggggtttactgtttggtgggcttcatcctcacc
            tatagaaaattcaattataaagacaatacagatctggtcgagtttaaaactctcactgag
            gaagaggttgaagaagtgctgagaaatatatttaagatttccttggggagaaatctcgtg
            cccaaacctggtgatggatcccttactatttag
///