ENTRY hsa05200 Pathway NAME Pathways in cancer - Homo sapiens (human) CLASS Human Diseases; Cancer: overview PATHWAY_MAP hsa05200 Pathways in cancer DRUG D00094 Tretinoin (JAN/USP/INN) D00327 Fluoxymesterone (JAN/USP/INN) D00408 Methyltestosterone (JP18/USP/INN) D00554 Ethinyl estradiol (USP) D00586 Flutamide (JP18/USP/INN) D00745 Interferon alfa-2a (USAN/INN) D00747 Interferon gamma-1b (USAN/INN) D00748 Aldesleukin (USAN/INN) D00753 Sirolimus (JAN/USAN/INN) D00958 Testosterone enanthate (JP18/USP) D00961 Bicalutamide (JP18/USP/INN) D00965 Nilutamide (USAN/INN) D00966 Tamoxifen citrate (JP18/USP) D00967 Toremifene citrate (JAN/USAN) D01161 Fulvestrant (JAN/USP/INN) D01441 Imatinib mesylate (USAN) D01534 Dromostanolone propionate (USAN) D01977 Gefitinib (JP18/USAN/INN) D02106 Arsenic trioxide (JP18/USAN) D02714 Everolimus (JAN/USAN/INN) D02745 Interferon alfa-2b (USAN) D02748 Peginterferon alfa-2b (USAN/INN) D02815 Alitretinoin (USAN) D02970 Aprinocarsen sodium (USAN) D03061 Batimastat (USAN/INN) D03106 Bexarotene (JAN/USAN/INN) D03218 Axitinib (JAN/USAN) D03235 Filgrastim (USP/INN) D03247 Lenograstim (USAN/INN) D03252 Bosutinib (USAN) D03257 Trastuzumab (USAN/INN) D03305 Interferon alfa (NAMALWA) (JP18) D03350 Canertinib dihydrochloride (USAN) D03357 Interferon gamma-1a (genetical recombination) (JAN) D03455 Cetuximab (USAN/INN) D03658 Dasatinib (JAN/INN) D03682 Denileukin diftitox (USAN/INN) D03800 Rebimastat (USAN/INN) D03802 Tanomastat (USAN/INN) D04014 Enzastaurin hydrochloride (JAN/USAN) D04023 Erlotinib hydrochloride (JAN/USAN) D04024 Lapatinib ditosylate (USAN) D04025 Mubritinib (USAN/INN) D04162 Fenretinide (USAN/INN) D04696 Lestaurtinib (USAN/INN) D04862 Masoprocol (USAN/INN) D05029 Midostaurin (JAN/USAN/INN) D05350 Panitumumab (USAN/INN) D05380 Pazopanib hydrochloride (JAN/USAN) D05386 Pegaptanib sodium (JAN/USAN) D05399 Pelitinib (USAN/INN) D05446 Pertuzumab (USAN/INN) D05803 Sargramostim (USP/INN) D05819 Semaxanib (USAN/INN) D06005 Tandutinib (USAN/INN) D06068 Temsirolimus (JAN/USAN/INN) D06272 Sorafenib tosylate (USAN) D06285 Vatalanib (USAN/INN) D06320 Vorinostat (JAN/USAN) D06402 Sunitinib malate (JAN/USAN) D06407 Vandetanib (JAN/USAN/INN) D06409 Bevacizumab (USAN) D06413 Nilotinib hydrochloride hydrate (JAN) D06414 Dasatinib (USAN) D06554 Alvespimycin hydrochloride (USAN) D06563 Belagenpumatucel-L (USAN) D06610 Lapuleucel-T (USAN) D06637 Romidepsin (JAN/USAN/INN) D06678 Motesanib (USAN) D06889 Pegfilgrastim (USAN/INN) D07434 Polyestradiol phosphate (INN) D07741 Zibotentan (JAN/USAN/INN) D07907 Erlotinib (INN) D08066 Imatinib (INN) D08108 Lapatinib (INN) D08524 Sorafenib (USAN/INN) D08552 Sunitinib (INN) D08559 Tamoxifen (INN) D08805 Interferon gamma-n1 (JAN) D08870 Belinostat (USAN/INN) D08881 Cediranib (USAN/INN) D08883 Cediranib maleate (JAN/USAN) D08900 Ridaforolimus (JAN/USAN/INN) D08917 Ezatiostat hydrochloride (USAN) D08947 Motesanib diphosphate (USAN) D08950 Neratinib (USAN/INN) D08953 Nilotinib (USAN/INN) D08956 Omacetaxine mepesuccinate (USAN) D08971 Plerixafor (JAN/USAN/INN) D09328 Cixutumumab (USAN) D09338 Entinostat (JAN/USAN/INN) D09357 Mocetinostat dihydrobromide (USAN) D09574 Aflibercept (USAN/INN) D09604 Dinaciclib (USAN/INN) D09629 Imetelstat (USAN/INN) D09630 Imetelstat sodium (USAN) D09635 Linifanib (USAN/INN) D09641 Mocetinostat (USAN/INN) D09659 Rilotumumab (USAN/INN) D09660 Rindopepimut (USAN) D09683 Tivozanib (USAN/INN) D09689 Varlitinib (USAN/INN) D09690 Varlitinib tosylate (USAN) D09724 Afatinib (USAN/INN) D09728 Bosutinib hydrate (JAN) D09731 Crizotinib (JAN/USAN/INN) D09733 Afatinib dimaleate (USAN) D09746 Dalotuzumab (USAN) D09864 Amuvatinib (USAN/INN) D09865 Amuvatinib hydrochloride (USAN) D09908 Ganitumab (USAN/INN) D09909 Gataparsen (USAN/INN) D09910 Gataparsen sodium (USAN) D09919 Lenvatinib (USAN/INN) D09920 Lenvatinib mesylate (USAN) D09939 Olaratumab (USAN/INN) D09941 Onartuzumab (USAN/INN) D09950 Ponatinib (USAN/INN) D09951 Ponatinib hydrochloride (JAN/USAN) D09955 Quizartinib (USAN/INN) D09956 Quizartinib dihydrochloride (USAN) D09959 Ruxolitinib (USAN/INN) D09960 Ruxolitinib phosphate (JAN/USAN) D09980 Trastuzumab emtansine (USAN/INN) D09992 Vismodegib (USAN/INN) D09996 Vemurafenib (JAN/USAN/INN) D10015 Litgenprostucel-L (USAN) D10019 Panobinostat lactate (JAN) D10031 Zalutumumab (USAN/INN) D10060 Abexinostat (USAN) D10062 Cabozantinib (USAN) D10064 Dabrafenib (USAN) D10076 Olcorolimus (USAN) D10084 Abexinostat hydrochloride (USAN) D10095 Cabozantinib s-malate (USAN) D10102 Crenolanib (USAN) D10103 Crenolanib besylate (USAN) D10104 Dabrafenib mesylate (USAN) D10119 Sonidegib (USAN/INN) D10123 Ficlatuzumab (USAN) D10137 Regorafenib hydrate (JAN) D10138 Regorafenib (USAN/INN) D10164 Sepantronium bromide (JAN/USAN) D10173 Tivantinib (JAN/USAN/INN) D10175 Trametinib (USAN) D10176 Trametinib dimethyl sulfoxide (JAN/USAN) D10189 Pictilisib (USAN/INN) D10190 Tivozanib hydrochloride (USAN) D10218 Enzalutamide (JAN/USAN) D10224 Golvatinib (USAN) D10229 Masitinib (INN) D10242 Lipegfilgrastim (USAN) D10319 Panobinostat (USAN/INN) D10321 Quisinostat (USAN/INN) D10322 Quisinostat hydrochloride (USAN) D10324 Patidegib (USAN/INN) D10325 Patidegib hydrochloride (USAN) D10334 Rebastinib (USAN) D10372 Palbociclib (JAN/USAN) D10381 Afuresertib (USAN/INN) D10382 Afuresertib hydrochloride (USAN) D10396 Nintedanib esylate (USAN) D10399 Rebastinib Tosylate (USAN) D10405 Cobimetinib (USAN/INN) D10410 Vantictumab (USAN/INN) D10423 Ilorasertib (USAN/INN) D10426 Pimasertib (USAN/INN) D10437 Galunisertib (USAN/INN) D10446 Margetuximab (USAN/INN) D10450 Alectinib hydrochloride (JAN) D10464 Firtecan pegol (USAN/INN) D10465 Golvatinib tartrate (USAN) D10481 Nintedanib (USAN/INN) D10486 Pimasertib hydrochloride (USAN) D10542 Alectinib (USAN/INN) D10543 Apitolisib (USAN/INN) D10551 Ceritinib (JAN/USAN/INN) D10552 Dactolisib (USAN/INN) D10555 Duvelisib (USAN/INN) D10560 Idelalisib (JAN/USAN/INN) D10584 Buparlisib (USAN/INN) D10604 Binimetinib (JAN/USAN/INN) D10609 Buparlisib hydrochloride (JAN/USAN) D10615 Cobimetinib fumarate (USAN) D10616 Dactolisib tosylate (USAN) D10635 Gedatolisib (USAN/INN) D10636 Glasdegib (USAN/INN) D10641 Ipatasertib (USAN/INN) D10652 Palbociclib isethionate (USAN) D10671 Taladegib (USAN/INN) D10679 Venetoclax (JAN/USAN/INN) D10688 Abemaciclib (JAN/USAN/INN) D10696 Capmatinib (USAN/INN) D10709 Gilteritinib (USAN/INN) D10717 Napabucasin (JAN/USAN/INN) D10718 Omipalisib (USAN/INN) D10729 Sonidegib phosphate (USAN) D10766 Osimertinib mesylate (USAN) D10797 Copanlisib hydrochloride (USAN) D10798 Copanlisib hydrochloride hydrate (JAN) D10800 Gilteritinib fumarate (JAN/USAN) D10858 Rociletinib (USAN/INN) D10859 Olmutinib (USAN/INN) D10866 Brigatinib (JAN/USAN) D10867 Copanlisib (USAN/INN) D10883 Ribociclib (USAN/INN) D10891 Capmatinib hydrochloride (USAN) D10898 Neratinib maleate D10924 Dezapelisib (USAN/INN) D10926 Entrectinib (JAN/USAN/INN) D10927 Erdafitinib (JAN/USAN/INN) D10958 Naquotinib (USAN/INN) D10977 Remetinostat (USAN/INN) D10979 Ribociclib succinate (USAN) D10981 Rovalpituzumab tesirine (USAN/INN) D10993 Tucidinostat (JAN/USAN/INN) D11011 Alpelisib (JAN/USAN/INN) D11012 Lorlatinib (JAN/USAN/INN) D11032 Plitidepsin (INN) D11038 Ulixertinib (INN) D11040 Apalutamide (JAN/INN) D11045 Darolutamide (JAN/USAN/INN) D11053 Encorafenib (JAN/USAN/INN) D11073 Tepotinib hydrochloride (USAN) D11074 Ipatasertib hydrochloride (JAN) D11107 Glasdegib maleate (JAN) D11115 Olmutinib hydrochloride (USAN) D11117 Rovalpituzumab (USAN) D11125 Modotuximab (USAN/INN) D11126 Navicixizumab (USAN/INN) D11130 Trilaciclib (USAN/INN) D11136 Glesatinib (USAN/INN) D11137 Larotrectinib (USAN/INN) D11138 Larotrectinib sulfate (JAN/USAN) D11139 Savolitinib (USAN/INN) D11140 Sitravatinib (USAN/INN) D11141 Tucatinib (USAN/INN) D11151 Crenigacestat (USAN/INN) D11182 Tinostamustine (USAN/INN) D11184 Ralaniten (USAN/INN) D11185 Ralaniten acetate (USAN) D11229 Brontictuzumab (USAN/INN) D11234 Emactuzumab (USAN/INN) D11251 Icotinib D11264 Brilanestrant (USAN/INN) D11270 Pexidartinib (USAN/INN) D11271 Pexidartinib hydrochloride (JAN/USAN) D11279 Avapritinib (USAN/INN) D11307 Telisotuzumab (USAN) D11323 Umbralisib tosylate (USAN) D11344 Telisotuzumab vedotin (USAN) D11346 Ensartinib (USAN) D11353 Ripretinib (USAN) D11356 Ensartinib hydrochloride (USAN) D11358 Tagraxofusp (USAN/INN) D11371 Capivasertib (JAN/USAN) D11403 Asciminib (USAN/INN) D11404 Asciminib hydrochloride (JAN/USAN) D11409 Miransertib (USAN/INN) D11410 Lifirafenib (USAN/INN) D11411 Lifirafenib maleate (USAN) D11417 Pemigatinib (JAN/USAN/INN) D11430 Nazartinib (USAN/INN) D11434 Nazartinib mesylate (USAN) D11437 Parsaclisib (USAN/INN) D11440 Bimiralisib (USAN/INN) D11442 Nanatinostat (USAN) D11454 Repotrectinib (JAN/USAN) D11455 Lerociclib (USAN) D11461 Derazantinib hydrochloride (USAN) D11501 Samotolisib (USAN) D11506 Parsaclisib hydrochloride (JAN/USAN) D11508 Miransertib mesylate (USAN) D11529 Trastuzumab deruxtecan (USAN/INN) D11541 Sitravatinib malate (USAN) D11589 Infigratinib (USAN/INN) D11599 Zotiraciclib (USAN) D11600 Zotiraciclib citrate (USAN) D11642 Dilpacimab (USAN/INN) D11658 Duvelisib hydrate (JAN) D11663 Onatasertib (USAN) D11669 Bempegaldesleukin (USAN/INN) D11671 Elacestrant (USAN/INN) D11672 Elacestrant hydrochloride (USAN) D11675 Mirdametinib (USAN) D11712 Pralsetinib (USAN/INN) D11713 Selpercatinib (JAN/USAN/INN) D11717 Tepotinib (USAN/INN) D11725 Futibatinib (JAN/USAN/INN) D11727 Voxtalisib (USAN/INN) D11737 Fisogatinib (USAN/INN) D11747 Inbakicept (USAN/INN) D11762 Lucitanib (USAN/INN) D11763 Merestinib (USAN/INN) D11768 Pacritinib (USAN/INN) D11772 Tesevatinib (USAN/INN) D11773 Tesevatinib tosylate (USAN) D11774 Taselisib (USAN/INN) D11775 Tarextumab (USAN/INN) D11786 Vodobatinib (USAN) D11803 Cetuximab sarotalocan (USAN/INN) D11805 Cetuximab sarotalocan sodium (genetical recombination) (JAN) D11872 Serclutamab (USAN/INN) D11874 Serclutamab talirine (USAN/INN) D11885 Surufatinib (USAN/INN) D11890 Emvododstat (USAN) D11894 Amivantamab (USAN/INN) D11935 Enzastaurin (USAN/INN) D11942 Inavolisib (USAN/INN) D11954 Belzutifan (JAN/USAN/INN) D11969 Mobocertinib succinate (JAN) D11980 Lazertinib (USAN) D11987 Trilaciclib dihydrochloride D12001 Mobocertinib (USAN/INN) D12009 Zandelisib (JAN/USAN/INN) D12011 Zanidatamab (USAN/INN) D12049 Camizestrant (JAN/USAN) D12055 Sotorasib (JAN/USAN) D12059 Temuterkib (USAN) D12060 Temuterkib mesylate (USAN) D12128 Balixafortide (USAN/INN) D12145 Amcenestrant (JAN/USAN/INN) D12175 Olverembatinib (USAN/INN) D12229 Poziotinib (USAN/INN) D12230 Poziotinib hydrochloride (USAN) D12245 Lazertinib mesilate hydrate (JAN) D12258 Aumolertinib (USAN/INN) D12259 Aumolertinib mesylate (USAN) D12281 Motixafortide (USAN/INN) D12282 Motixafortide acetate (USAN) D12301 Adagrasib (USAN/INN) D12303 Deutenzalutamide (USAN) D12304 Elraglusib (USAN) D12307 Pivekimab (USAN) D12316 Bavdegalutamide (USAN) D12330 Zeteletinib (USAN) D12331 Zeteletinib adipate (USAN) D12354 Pralsetinib hydrate (JAN) D12363 Taletrectinib (USAN/INN) D12364 Taletrectinib adipate (USAN) D12399 Sulanemadlin (USAN/INN) D12404 Tasurgratinib (INN) D12405 Tasurgratinib succinate (JAN) D12416 Petosemtamab (USAN/INN) D12424 Davutamig (USAN) D12432 Zurletrectinib (USAN) D12442 Tucatinib ethanolate (JAN) D12444 Nilotinib hydrochloride dihydrate (JAN) D12445 Foscenvivint (JAN/INN) D12457 Tuxobertinib (USAN/INN) D12476 Tuspetinib (USAN/INN) D12506 Sunvozertinib (USAN/INN) D12514 Amdizalisib (USAN/INN) D12515 Avutometinib (USAN/INN) D12526 Catequentinib (USAN/INN) D12531 Nadofaragene firadenovec (USAN/INN) D12534 Avutometinib potassium (USAN) D12537 Catequentinib hydrochloride (USAN) D12545 Tinengotinib (USAN/INN) D12551 Bocodepsin (USAN) D12552 Bocodepsin besylate (USAN) D12557 Elzovantinib (USAN/INN) D12558 Emzadirib (USAN) D12559 Enbezotinib (USAN/INN) D12583 Anvatabart opadotin (USAN/INN) D12584 Anvatabart pactil (USAN/INN) D12600 Bezuclastinib (USAN/INN) D12601 Tagtociclib (USAN) D12625 Pegenzileukin (USAN/INN) D12628 Vepdegestrant (JAN/USAN/INN) D12639 Divarasib (USAN/INN) D12640 Divarasib adipate (USAN) D12641 Emirodatamab (USAN/INN) D12643 Masofaniten (USAN/INN) D12646 Paltimatrectinib (USAN/INN) D12650 Zanzalintinib (USAN/INN) D12651 Zanzalintinib fumarate (USAN) D12705 Gumarontinib hydrate (JAN) D12730 Tigozertinib (USAN) D12768 Ficerafusp alfa (USAN) D12809 Bafisontamab (USAN/INN) D12827 Palazestrant (USAN/INN) D12831 Naporafenib (USAN/INN) D12834 Atirmociclib (USAN) D12836 Risovalisib (INN) D12837 Risovalisib mesilate hydrate (JAN) D12853 Olomorasib (USAN) D12854 Nilotinib laurylsulfate (USAN) D12859 Pebezertinib (USAN) D12865 Beroterkib (USAN) D12866 Gridegalutamide (USAN) ORGANISM Homo sapiens (human) [GN:hsa] GENE 1630 DCC; DCC netrin 1 receptor [KO:K06765] 836 CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56] 842 CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62] 26060 APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 [KO:K08733] 999 CDH1; cadherin 1 [KO:K05689] 1499 CTNNB1; catenin beta 1 [KO:K02105] 29119 CTNNA3; catenin alpha 3 [KO:K05691] 1495 CTNNA1; catenin alpha 1 [KO:K05691] 1496 CTNNA2; catenin alpha 2 [KO:K05691] 8312 AXIN1; axin 1 [KO:K02157] 8313 AXIN2; axin 2 [KO:K04385] 324 APC; APC regulator of WNT signaling pathway [KO:K02085] 10297 APC2; APC regulator of WNT signaling pathway 2 [KO:K02085] 2932 GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26] 6932 TCF7; transcription factor 7 [KO:K02620] 83439 TCF7L1; transcription factor 7 like 1 [KO:K04490] 6934 TCF7L2; transcription factor 7 like 2 [KO:K04491] 51176 LEF1; lymphoid enhancer binding factor 1 [KO:K04492] 332 BIRC5; baculoviral IAP repeat containing 5 [KO:K08731] 4609 MYC; MYC proto-oncogene, bHLH transcription factor [KO:K04377] 595 CCND1; cyclin D1 [KO:K04503] 7471 WNT1; Wnt family member 1 [KO:K03209] 7472 WNT2; Wnt family member 2 [KO:K00182] 7482 WNT2B; Wnt family member 2B [KO:K00182] 7473 WNT3; Wnt family member 3 [KO:K00312] 89780 WNT3A; Wnt family member 3A [KO:K00312] 54361 WNT4; Wnt family member 4 [KO:K00408] 7474 WNT5A; Wnt family member 5A [KO:K00444] 81029 WNT5B; Wnt family member 5B [KO:K00444] 7475 WNT6; Wnt family member 6 [KO:K00445] 7476 WNT7A; Wnt family member 7A [KO:K00572] 7477 WNT7B; Wnt family member 7B [KO:K00572] 7478 WNT8A; Wnt family member 8A [KO:K00714] 7479 WNT8B; Wnt family member 8B [KO:K00714] 7483 WNT9A; Wnt family member 9A [KO:K01064] 7484 WNT9B; Wnt family member 9B [KO:K01064] 7480 WNT10B; Wnt family member 10B [KO:K01357] 80326 WNT10A; Wnt family member 10A [KO:K01357] 7481 WNT11; Wnt family member 11 [KO:K01384] 51384 WNT16; Wnt family member 16 [KO:K01558] 8321 FZD1; frizzled class receptor 1 [KO:K02432] 8324 FZD7; frizzled class receptor 7 [KO:K02432] 2535 FZD2; frizzled class receptor 2 [KO:K02235] 7976 FZD3; frizzled class receptor 3 [KO:K02329] 8322 FZD4; frizzled class receptor 4 [KO:K02354] 7855 FZD5; frizzled class receptor 5 [KO:K02375] 8325 FZD8; frizzled class receptor 8 [KO:K02375] 8323 FZD6; frizzled class receptor 6 [KO:K02376] 11211 FZD10; frizzled class receptor 10 [KO:K02842] 8326 FZD9; frizzled class receptor 9 [KO:K02842] 4041 LRP5; LDL receptor related protein 5 [KO:K03068] 4040 LRP6; LDL receptor related protein 6 [KO:K03068] 1857 DVL3; dishevelled segment polarity protein 3 [KO:K02353] 1856 DVL2; dishevelled segment polarity protein 2 [KO:K02353] 1855 DVL1; dishevelled segment polarity protein 1 [KO:K02353] 10023 FRAT1; FRAT regulator of WNT signaling pathway 1 [KO:K03069] 23401 FRAT2; FRAT regulator of WNT signaling pathway 2 [KO:K03096] 2147 F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5] 183 AGT; angiotensinogen [KO:K09821] 2149 F2R; coagulation factor II thrombin receptor [KO:K03914] 9002 F2RL3; F2R like thrombin or trypsin receptor 3 [KO:K04236] 1902 LPAR1; lysophosphatidic acid receptor 1 [KO:K04289] 9170 LPAR2; lysophosphatidic acid receptor 2 [KO:K04291] 23566 LPAR3; lysophosphatidic acid receptor 3 [KO:K04294] 2846 LPAR4; lysophosphatidic acid receptor 4 [KO:K04275] 57121 LPAR5; lysophosphatidic acid receptor 5 [KO:K08390] 10161 LPAR6; lysophosphatidic acid receptor 6 [KO:K04273] 185 AGTR1; angiotensin II receptor type 1 [KO:K04166] 2768 GNA12; G protein subunit alpha 12 [KO:K04346] 10672 GNA13; G protein subunit alpha 13 [KO:K04639] 23365 ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532] 9826 ARHGEF11; Rho guanine nucleotide exchange factor 11 [KO:K12331] 9138 ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330] 57449 PLEKHG5; pleckstrin homology and RhoGEF domain containing G5 [KO:K19464] 387 RHOA; ras homolog family member A [KO:K04513] 6093 ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1] 9475 ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1] 6387 CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031] 7852 CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189] 2770 GNAI1; G protein subunit alpha i1 [KO:K04630] 2773 GNAI3; G protein subunit alpha i3 [KO:K04630] 2771 GNAI2; G protein subunit alpha i2 [KO:K04630] 5731 PTGER1; prostaglandin E receptor 1 [KO:K04258] 5732 PTGER2; prostaglandin E receptor 2 [KO:K04259] 5733 PTGER3; prostaglandin E receptor 3 [KO:K04260] 5734 PTGER4; prostaglandin E receptor 4 [KO:K04261] 2778 GNAS; GNAS complex locus [KO:K04632] 107 ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1] 108 ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1] 109 ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1] 196883 ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1] 111 ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1] 112 ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1] 113 ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1] 114 ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1] 115 ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1] 5566 PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11] 5567 PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11] 5568 PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11] 2782 GNB1; G protein subunit beta 1 [KO:K04536] 2783 GNB2; G protein subunit beta 2 [KO:K04537] 2784 GNB3; G protein subunit beta 3 [KO:K07825] 59345 GNB4; G protein subunit beta 4 [KO:K04538] 10681 GNB5; G protein subunit beta 5 [KO:K04539] 54331 GNG2; G protein subunit gamma 2 [KO:K07826] 2785 GNG3; G protein subunit gamma 3 [KO:K04540] 2786 GNG4; G protein subunit gamma 4 [KO:K04541] 2787 GNG5; G protein subunit gamma 5 [KO:K04542] 2788 GNG7; G protein subunit gamma 7 [KO:K04543] 94235 GNG8; G protein subunit gamma 8 [KO:K04544] 2790 GNG10; G protein subunit gamma 10 [KO:K04545] 2791 GNG11; G protein subunit gamma 11 [KO:K04546] 55970 GNG12; G protein subunit gamma 12 [KO:K04347] 51764 GNG13; G protein subunit gamma 13 [KO:K04547] 2792 GNGT1; G protein subunit gamma transducin 1 [KO:K04548] 2793 GNGT2; G protein subunit gamma transducin 2 [KO:K04549] 1284 COL4A2; collagen type IV alpha 2 chain [KO:K06237] 1286 COL4A4; collagen type IV alpha 4 chain [KO:K06237] 1288 COL4A6; collagen type IV alpha 6 chain [KO:K06237] 1282 COL4A1; collagen type IV alpha 1 chain [KO:K06237] 1287 COL4A5; collagen type IV alpha 5 chain [KO:K06237] 1285 COL4A3; collagen type IV alpha 3 chain [KO:K06237] 284217 LAMA1; laminin subunit alpha 1 [KO:K05637] 3908 LAMA2; laminin subunit alpha 2 [KO:K05637] 3909 LAMA3; laminin subunit alpha 3 [KO:K06240] 3911 LAMA5; laminin subunit alpha 5 [KO:K06240] 3910 LAMA4; laminin subunit alpha 4 [KO:K06241] 3912 LAMB1; laminin subunit beta 1 [KO:K05636] 3913 LAMB2; laminin subunit beta 2 [KO:K06243] 3914 LAMB3; laminin subunit beta 3 [KO:K06244] 22798 LAMB4; laminin subunit beta 4 [KO:K06245] 3915 LAMC1; laminin subunit gamma 1 [KO:K05635] 3918 LAMC2; laminin subunit gamma 2 [KO:K06246] 10319 LAMC3; laminin subunit gamma 3 [KO:K06247] 2335 FN1; fibronectin 1 [KO:K05717] 3673 ITGA2; integrin subunit alpha 2 [KO:K06481] 3674 ITGA2B; integrin subunit alpha 2b [KO:K06476] 3675 ITGA3; integrin subunit alpha 3 [KO:K06482] 3655 ITGA6; integrin subunit alpha 6 [KO:K06485] 3685 ITGAV; integrin subunit alpha V [KO:K06487] 3688 ITGB1; integrin subunit beta 1 [KO:K05719] 5747 PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2] 5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153] 5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153] 5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153] 5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649] 5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649] 8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649] 5728 PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67] 4824 NKX3-1; NK3 homeobox 1 [KO:K09348] 207 AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1] 208 AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1] 10000 AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1] 1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex [KO:K04467] [EC:2.7.11.10] 3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10] 8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [KO:K07210] 4792 NFKBIA; NFKB inhibitor alpha [KO:K04734] 4790 NFKB1; nuclear factor kappa B subunit 1 [KO:K02580] 4791 NFKB2; nuclear factor kappa B subunit 2 [KO:K04469] 5970 RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735] 5743 PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1] 4843 NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39] 596 BCL2; BCL2 apoptosis regulator [KO:K02161] 329 BIRC2; baculoviral IAP repeat containing 2 [KO:K16060] 330 BIRC3; baculoviral IAP repeat containing 3 [KO:K16060] 331 XIAP; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27] 79444 BIRC7; baculoviral IAP repeat containing 7 [KO:K16061] 598 BCL2L1; BCL2 like 1 [KO:K04570] 7185 TRAF1; TNF receptor associated factor 1 [KO:K03172] 7186 TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27] 7187 TRAF3; TNF receptor associated factor 3 [KO:K03174] 9618 TRAF4; TNF receptor associated factor 4 [KO:K09848] 7188 TRAF5; TNF receptor associated factor 5 [KO:K09849] 7189 TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27] 2475 MTOR; mechanistic target of rapamycin kinase [KO:K07203] [EC:2.7.11.1] 6198 RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1] 6199 RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1] 572 BAD; BCL2 associated agonist of cell death [KO:K02158] 2308 FOXO1; forkhead box O1 [KO:K07201] 4193 MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27] 7157 TP53; tumor protein p53 [KO:K04451] 1027 CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624] 1026 CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625] 613 BCR; BCR activator of RhoGEF and GTPase [KO:K08878] [EC:2.7.11.1] 25 ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2] 1398 CRK; CRK proto-oncogene, adaptor protein [KO:K04438] 1399 CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438] 867 CBL; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27] 6776 STAT5A; signal transducer and activator of transcription 5A [KO:K11223] 6777 STAT5B; signal transducer and activator of transcription 5B [KO:K11224] 5292 PIM1; Pim-1 proto-oncogene, serine/threonine kinase [KO:K04702] [EC:2.7.11.1] 11040 PIM2; Pim-2 proto-oncogene, serine/threonine kinase [KO:K08806] [EC:2.7.11.1] 3827 KNG1; kininogen 1 [KO:K03898] 1906 EDN1; endothelin 1 [KO:K16366] 623 BDKRB1; bradykinin receptor B1 [KO:K03915] 624 BDKRB2; bradykinin receptor B2 [KO:K03916] 1909 EDNRA; endothelin receptor type A [KO:K04197] 1910 EDNRB; endothelin receptor type B [KO:K04198] 2776 GNAQ; G protein subunit alpha q [KO:K04634] 2767 GNA11; G protein subunit alpha 11 [KO:K04635] 23236 PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11] 5330 PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11] 5331 PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11] 5332 PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11] 5578 PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13] 5579 PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13] 5582 PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13] 3558 IL2; interleukin 2 [KO:K05429] 3562 IL3; interleukin 3 [KO:K04736] 3565 IL4; interleukin 4 [KO:K05430] 3567 IL5; interleukin 5 [KO:K05428] 3569 IL6; interleukin 6 [KO:K05405] 3574 IL7; interleukin 7 [KO:K05431] 3592 IL12A; interleukin 12A [KO:K05406] 3593 IL12B; interleukin 12B [KO:K05425] 3596 IL13; interleukin 13 [KO:K05435] 3600 IL15; interleukin 15 [KO:K05433] 51561 IL23A; interleukin 23 subunit alpha [KO:K05426] 2056 EPO; erythropoietin [KO:K05437] 3439 IFNA1; interferon alpha 1 [KO:K05414] 3440 IFNA2; interferon alpha 2 [KO:K05414] 3441 IFNA4; interferon alpha 4 [KO:K05414] 3442 IFNA5; interferon alpha 5 [KO:K05414] 3443 IFNA6; interferon alpha 6 [KO:K05414] 3444 IFNA7; interferon alpha 7 [KO:K05414] 3445 IFNA8; interferon alpha 8 [KO:K05414] 3446 IFNA10; interferon alpha 10 [KO:K05414] 3447 IFNA13; interferon alpha 13 [KO:K05414] 3448 IFNA14; interferon alpha 14 [KO:K05414] 3449 IFNA16; interferon alpha 16 [KO:K05414] 3451 IFNA17; interferon alpha 17 [KO:K05414] 3452 IFNA21; interferon alpha 21 [KO:K05414] 3458 IFNG; interferon gamma [KO:K04687] 3559 IL2RA; interleukin 2 receptor subunit alpha [KO:K05068] 3560 IL2RB; interleukin 2 receptor subunit beta [KO:K05069] 3561 IL2RG; interleukin 2 receptor subunit gamma [KO:K05070] 3563 IL3RA; interleukin 3 receptor subunit alpha [KO:K04737] 3566 IL4R; interleukin 4 receptor [KO:K05071] 1439 CSF2RB; colony stimulating factor 2 receptor subunit beta [KO:K04738] 3568 IL5RA; interleukin 5 receptor subunit alpha [KO:K05067] 3570 IL6R; interleukin 6 receptor [KO:K05055] 3572 IL6ST; interleukin 6 cytokine family signal transducer [KO:K05060] 3575 IL7R; interleukin 7 receptor [KO:K05072] 3594 IL12RB1; interleukin 12 receptor subunit beta 1 [KO:K05063] 3595 IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064] 3597 IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076] 3601 IL15RA; interleukin 15 receptor subunit alpha [KO:K05074] 149233 IL23R; interleukin 23 receptor [KO:K05065] 2057 EPOR; erythropoietin receptor [KO:K05079] 3454 IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130] 3455 IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131] 3459 IFNGR1; interferon gamma receptor 1 [KO:K05132] 3460 IFNGR2; interferon gamma receptor 2 [KO:K05133] 27436 EML4; EMAP like 4 [KO:K15420] 238 ALK; ALK receptor tyrosine kinase [KO:K05119] [EC:2.7.10.1] 10125 RASGRP1; RAS guanyl releasing protein 1 [KO:K04350] 10235 RASGRP2; RAS guanyl releasing protein 2 [KO:K12361] 25780 RASGRP3; RAS guanyl releasing protein 3 [KO:K12362] 115727 RASGRP4; RAS guanyl releasing protein 4 [KO:K12363] 3716 JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2] 3717 JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2] 3718 JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2] 6774 STAT3; signal transducer and activator of transcription 3 [KO:K04692] 6772 STAT1; signal transducer and activator of transcription 1 [KO:K11220] 6773 STAT2; signal transducer and activator of transcription 2 [KO:K11221] 6775 STAT4; signal transducer and activator of transcription 4 [KO:K11222] 6778 STAT6; signal transducer and activator of transcription 6 [KO:K11225] 7422 VEGFA; vascular endothelial growth factor A [KO:K05448] 7423 VEGFB; vascular endothelial growth factor B [KO:K16858] 5228 PGF; placental growth factor [KO:K16859] 7424 VEGFC; vascular endothelial growth factor C [KO:K05449] 2277 VEGFD; vascular endothelial growth factor D [KO:K05449] 7039 TGFA; transforming growth factor alpha [KO:K08774] 1950 EGF; epidermal growth factor [KO:K04357] 1956 EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1] 2064 ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1] 5154 PDGFA; platelet derived growth factor subunit A [KO:K04359] 5155 PDGFB; platelet derived growth factor subunit B [KO:K17386] 5156 PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1] 5159 PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1] 3479 IGF1; insulin like growth factor 1 [KO:K05459] 3481 IGF2; insulin like growth factor 2 [KO:K13769] 3480 IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1] 4254 KITLG; KIT ligand [KO:K05461] 3815 KIT; KIT proto-oncogene, receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1] 2323 FLT3LG; fms related receptor tyrosine kinase 3 ligand [KO:K05454] 2322 FLT3; fms related receptor tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1] 3082 HGF; hepatocyte growth factor [KO:K05460] 4233 MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1] 2246 FGF1; fibroblast growth factor 1 [KO:K18496] 2247 FGF2; fibroblast growth factor 2 [KO:K18497] 2248 FGF3; fibroblast growth factor 3 [KO:K04358] 2249 FGF4; fibroblast growth factor 4 [KO:K04358] 8822 FGF17; fibroblast growth factor 17 [KO:K04358] 2251 FGF6; fibroblast growth factor 6 [KO:K04358] 2252 FGF7; fibroblast growth factor 7 [KO:K04358] 2253 FGF8; fibroblast growth factor 8 [KO:K04358] 2254 FGF9; fibroblast growth factor 9 [KO:K04358] 2255 FGF10; fibroblast growth factor 10 [KO:K04358] 8823 FGF16; fibroblast growth factor 16 [KO:K04358] 2250 FGF5; fibroblast growth factor 5 [KO:K04358] 8817 FGF18; fibroblast growth factor 18 [KO:K04358] 26281 FGF20; fibroblast growth factor 20 [KO:K04358] 27006 FGF22; fibroblast growth factor 22 [KO:K04358] 9965 FGF19; fibroblast growth factor 19 [KO:K22603] 26291 FGF21; fibroblast growth factor 21 [KO:K22429] 8074 FGF23; fibroblast growth factor 23 [KO:K22428] 2260 FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1] 2263 FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1] 2261 FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1] 2264 FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1] 2885 GRB2; growth factor receptor bound protein 2 [KO:K04364] 6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099] 6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099] 3265 HRAS; HRas proto-oncogene, GTPase [KO:K02833] 3845 KRAS; KRAS proto-oncogene, GTPase [KO:K07827] 4893 NRAS; NRAS proto-oncogene, GTPase [KO:K07828] 369 ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1] 673 BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1] 5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1] 5604 MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2] 5605 MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2] 5594 MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24] 5595 MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24] 3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448] 2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379] 2113 ETS1; ETS proto-oncogene 1, transcription factor [KO:K02678] 4312 MMP1; matrix metallopeptidase 1 [KO:K01388] [EC:3.4.24.7] 4313 MMP2; matrix metallopeptidase 2 [KO:K01398] [EC:3.4.24.24] 4318 MMP9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35] 3576 CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030] 1019 CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22] 9252 RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1] 5979 RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1] 8030 CCDC6; coiled-coil domain containing 6 [KO:K09288] 8031 NCOA4; nuclear receptor coactivator 4 [KO:K09289] 4914 NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1] 7170 TPM3; tropomyosin 3 [KO:K09290] 7175 TPR; translocated promoter region, nuclear basket protein [KO:K09291] 10342 TFG; trafficking from ER to golgi regulator [KO:K09292] 11186 RASSF1; Ras association domain family member 1 [KO:K09850] 83593 RASSF5; Ras association domain family member 5 [KO:K08015] 6789 STK4; serine/threonine kinase 4 [KO:K04411] 1612 DAPK1; death associated protein kinase 1 [KO:K08803] [EC:2.7.11.1] 1613 DAPK3; death associated protein kinase 3 [KO:K08803] [EC:2.7.11.1] 23604 DAPK2; death associated protein kinase 2 [KO:K08803] [EC:2.7.11.1] 5335 PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11] 5336 PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11] 2002 ELK1; ETS transcription factor ELK1 [KO:K04375] 810 CALML3; calmodulin like 3 [KO:K02183] 805 CALM2; calmodulin 2 [KO:K02183] 808 CALM3; calmodulin 3 [KO:K02183] 801 CALM1; calmodulin 1 [KO:K02183] 163688 CALML6; calmodulin like 6 [KO:K02183] 51806 CALML5; calmodulin like 5 [KO:K02183] 91860 CALML4; calmodulin like 4 [KO:K02183] 815 CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17] 817 CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17] 816 CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17] 818 CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17] 5900 RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732] 5898 RALA; RAS like proto-oncogene A [KO:K07834] 5899 RALB; RAS like proto-oncogene B [KO:K07835] 10928 RALBP1; ralA binding protein 1 [KO:K08773] 998 CDC42; cell division cycle 42 [KO:K04393] 5879 RAC1; Rac family small GTPase 1 [KO:K04392] 5880 RAC2; Rac family small GTPase 2 [KO:K07860] 5881 RAC3; Rac family small GTPase 3 [KO:K07861] 5337 PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4] 5338 PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4] 5599 MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24] 5602 MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24] 5601 MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24] 7849 PAX8; paired box 8 [KO:K09293] 5468 PPARG; peroxisome proliferator activated receptor gamma [KO:K08530] 6256 RXRA; retinoid X receptor alpha [KO:K08524] 6257 RXRB; retinoid X receptor beta [KO:K08525] 6258 RXRG; retinoid X receptor gamma [KO:K08526] 5915 RARB; retinoic acid receptor beta [KO:K08528] 2099 ESR1; estrogen receptor 1 [KO:K08550] 2100 ESR2; estrogen receptor 2 [KO:K08551] 8648 NCOA1; nuclear receptor coactivator 1 [KO:K09101] [EC:2.3.1.48] 8202 NCOA3; nuclear receptor coactivator 3 [KO:K11256] [EC:2.3.1.48] 6667 SP1; Sp1 transcription factor [KO:K04684] 5467 PPARD; peroxisome proliferator activated receptor delta [KO:K04504] 3728 JUP; junction plakoglobin [KO:K10056] 7704 ZBTB16; zinc finger and BTB domain containing 16 [KO:K10055] 5914 RARA; retinoic acid receptor alpha [KO:K08527] 890 CCNA2; cyclin A2 [KO:K06627] 8900 CCNA1; cyclin A1 [KO:K06627] 5371 PML; PML nuclear body scaffold [KO:K10054] [EC:2.3.2.-] 861 RUNX1; RUNX family transcription factor 1 [KO:K08367] 862 RUNX1T1; RUNX1 partner transcriptional co-repressor 1 [KO:K10053] 6688 SPI1; Spi-1 proto-oncogene [KO:K09438] 1050 CEBPA; CCAAT enhancer binding protein alpha [KO:K09055] 1438 CSF2RA; colony stimulating factor 2 receptor subunit alpha [KO:K05066] 1441 CSF3R; colony stimulating factor 3 receptor [KO:K05061] 1436 CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1] 1029 CDKN2A; cyclin dependent kinase inhibitor 2A [KO:K06621] 1869 E2F1; E2F transcription factor 1 [KO:K17454] 1870 E2F2; E2F transcription factor 2 [KO:K09389] 1871 E2F3; E2F transcription factor 3 [KO:K06620] 4149 MAX; MYC associated factor X [KO:K04453] 7709 ZBTB17; zinc finger and BTB domain containing 17 [KO:K10500] 1030 CDKN2B; cyclin dependent kinase inhibitor 2B [KO:K04685] 1021 CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22] 894 CCND2; cyclin D2 [KO:K10151] 896 CCND3; cyclin D3 [KO:K10152] 1163 CKS1B; CDC28 protein kinase regulatory subunit 1B [KO:K02219] 1164 CKS2; CDC28 protein kinase regulatory subunit 2 [KO:K02219] 6500 SKP1; S-phase kinase associated protein 1 [KO:K03094] 8454 CUL1; cullin 1 [KO:K03347] 9978 RBX1; ring-box 1 [KO:K03868] [EC:2.3.2.32] 6502 SKP2; S-phase kinase associated protein 2 [KO:K03875] 1017 CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22] 898 CCNE1; cyclin E1 [KO:K06626] 9134 CCNE2; cyclin E2 [KO:K06626] 5925 RB1; RB transcriptional corepressor 1 [KO:K06618] 1647 GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402] 4616 GADD45B; growth arrest and DNA damage inducible beta [KO:K04402] 10912 GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402] 581 BAX; BCL2 associated X, apoptosis regulator [KO:K02159] 578 BAK1; BCL2 antagonist/killer 1 [KO:K14021] 1643 DDB2; damage specific DNA binding protein 2 [KO:K10140] 51426 POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7] 7015 TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49] 7012 TERC; telomerase RNA component [KO:K22183] 4286 MITF; melanocyte inducing transcription factor [KO:K09455] 7040 TGFB1; transforming growth factor beta 1 [KO:K13375] 7042 TGFB2; transforming growth factor beta 2 [KO:K13376] 7043 TGFB3; transforming growth factor beta 3 [KO:K13377] 7046 TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30] 7048 TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30] 4087 SMAD2; SMAD family member 2 [KO:K04500] 4088 SMAD3; SMAD family member 3 [KO:K23605] 4089 SMAD4; SMAD family member 4 [KO:K04501] 2122 MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367] 1487 CTBP1; C-terminal binding protein 1 [KO:K04496] [EC:1.1.1.428] 1488 CTBP2; C-terminal binding protein 2 [KO:K04496] [EC:1.1.1.428] 3065 HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98] 3066 HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98] 4292 MLH1; mutL homolog 1 [KO:K08734] 4436 MSH2; mutS homolog 2 [KO:K08735] 4437 MSH3; mutS homolog 3 [KO:K08736] 2956 MSH6; mutS homolog 6 [KO:K08737] 675 BRCA2; BRCA2 DNA repair associated [KO:K08775] 5888 RAD51; RAD51 recombinase [KO:K04482] 356 FASLG; Fas ligand [KO:K04389] 355 FAS; Fas cell surface death receptor [KO:K04390] 8772 FADD; Fas associated via death domain [KO:K02373] 841 CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61] 637 BID; BH3 interacting domain death agonist [KO:K04726] 5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131] 27113 BBC3; BCL2 binding component 3 [KO:K10132] 10018 BCL2L11; BCL2 like 11 [KO:K16341] 54205 CYCS; cytochrome c, somatic [KO:K08738] 317 APAF1; apoptotic peptidase activating factor 1 [KO:K02084] 840 CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60] 9817 KEAP1; kelch like ECH associated protein 1 [KO:K10456] 4780 NFE2L2; NFE2 like bZIP transcription factor 2 [KO:K05638] 3162 HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18] 1728 NQO1; NAD(P)H quinone dehydrogenase 1 [KO:K00355] [EC:1.6.5.2] 221357 GSTA5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18] 2939 GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18] 2941 GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18] 119391 GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18] 2948 GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18] 2953 GSTT2; glutathione S-transferase theta 2 (gene/pseudogene) [KO:K00799] [EC:2.5.1.18] 2952 GSTT1; glutathione S-transferase theta 1 [KO:K00799] [EC:2.5.1.18] 2947 GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18] 4257 MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18] 4259 MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18] 2944 GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18] 2949 GSTM5; glutathione S-transferase mu 5 [KO:K00799] [EC:2.5.1.18] 4258 MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18] 2938 GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18] 2946 GSTM2; glutathione S-transferase mu 2 [KO:K00799] [EC:2.5.1.18] 2940 GSTA3; glutathione S-transferase alpha 3 [KO:K00799] [EC:2.5.1.18] 9446 GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18] 653689 GSTT2B; glutathione S-transferase theta 2B [KO:K00799] [EC:2.5.1.18] 2950 GSTP1; glutathione S-transferase pi 1 [KO:K23790] [EC:2.5.1.18] 7296 TXNRD1; thioredoxin reductase 1 [KO:K22182] [EC:1.8.1.9] 114112 TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9] 10587 TXNRD2; thioredoxin reductase 2 [KO:K22182] [EC:1.8.1.9] 7428 VHL; von Hippel-Lindau tumor suppressor [KO:K03871] 6921 ELOC; elongin C [KO:K03872] 6923 ELOB; elongin B [KO:K03873] 8453 CUL2; cullin 2 [KO:K03870] 54583 EGLN1; egl-9 family hypoxia inducible factor 1 [KO:K09592] [EC:1.14.11.29] 112399 EGLN3; egl-9 family hypoxia inducible factor 3 [KO:K09592] [EC:1.14.11.29] 112398 EGLN2; egl-9 family hypoxia inducible factor 2 [KO:K09592] [EC:1.14.11.29] 2271 FH; fumarate hydratase [KO:K01679] [EC:4.2.1.2] 3091 HIF1A; hypoxia inducible factor 1 subunit alpha [KO:K08268] 2034 EPAS1; endothelial PAS domain protein 1 [KO:K09095] 405 ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097] 9915 ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589] 1387 CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48] 2033 EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48] 6513 SLC2A1; solute carrier family 2 member 1 [KO:K07299] 182 JAG1; jagged canonical Notch ligand 1 [KO:K06052] 3714 JAG2; jagged canonical Notch ligand 2 [KO:K21635] 10683 DLL3; delta like canonical Notch ligand 3 [KO:K06051] 28514 DLL1; delta like canonical Notch ligand 1 [KO:K06051] 54567 DLL4; delta like canonical Notch ligand 4 [KO:K06051] 4851 NOTCH1; notch receptor 1 [KO:K02599] 4853 NOTCH2; notch receptor 2 [KO:K20994] 4854 NOTCH3; notch receptor 3 [KO:K20995] 4855 NOTCH4; notch receptor 4 [KO:K20996] 3280 HES1; hes family bHLH transcription factor 1 [KO:K06054] 388585 HES5; hes family bHLH transcription factor 5 [KO:K06055] 26508 HEYL; hes related family bHLH transcription factor with YRPW motif like [KO:K09091] 23462 HEY1; hes related family bHLH transcription factor with YRPW motif 1 [KO:K09091] 23493 HEY2; hes related family bHLH transcription factor with YRPW motif 2 [KO:K09091] 2324 FLT4; fms related receptor tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1] 6469 SHH; sonic hedgehog signaling molecule [KO:K11988] 5727 PTCH1; patched 1 [KO:K06225] 6608 SMO; smoothened, frizzled class receptor [KO:K06226] 374654 KIF7; kinesin family member 7 [KO:K18806] 51684 SUFU; SUFU negative regulator of hedgehog signaling [KO:K06229] 2735 GLI1; GLI family zinc finger 1 [KO:K16797] 2736 GLI2; GLI family zinc finger 2 [KO:K16798] 2737 GLI3; GLI family zinc finger 3 [KO:K06230] 650 BMP2; bone morphogenetic protein 2 [KO:K21283] 652 BMP4; bone morphogenetic protein 4 [KO:K04662] 64399 HHIP; hedgehog interacting protein [KO:K06231] 8643 PTCH2; patched 2 [KO:K11101] 367 AR; androgen receptor [KO:K08557] 3320 HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079] 3326 HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079] 7184 HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487] 354 KLK3; kallikrein related peptidase 3 [KO:K01351] [EC:3.4.21.77] COMPOUND C00027 Hydrogen peroxide C00039 DNA C00076 Calcium cation C00122 Fumarate C00149 (S)-Malate C00165 Diacylglycerol C00187 Cholesterol C00280 Androstenedione C00410 Progesterone C00416 Phosphatidate C00533 Nitric oxide C00535 Testosterone C00575 3',5'-Cyclic AMP C00584 Prostaglandin E2 C00681 1-Acyl-sn-glycerol 3-phosphate C00704 Superoxide C00735 Cortisol C00762 Cortisone C00777 Retinoate C00951 Estradiol-17beta C01227 Dehydroepiandrosterone C01245 D-myo-Inositol 1,4,5-trisphosphate C01471 Acrolein C03917 Dihydrotestosterone C05981 Phosphatidylinositol-3,4,5-trisphosphate C07653 Flutamide C15493 9-cis-Retinoic acid C16038 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine C16844 Hydroxyl radical C21641 Hydroperoxyl radical C21642 4-Hydroxynonenal REFERENCE AUTHORS Weinberg RA. 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JOURNAL Nat Rev Cancer 7:79-94 (2007) DOI:10.1038/nrc2069 REL_PATHWAY hsa03320 PPAR signaling pathway hsa04010 MAPK signaling pathway hsa04020 Calcium signaling pathway hsa04024 cAMP signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04066 HIF-1 signaling pathway hsa04110 Cell cycle hsa04115 p53 signaling pathway hsa04150 mTOR signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04210 Apoptosis hsa04310 Wnt signaling pathway hsa04330 Notch signaling pathway hsa04340 Hedgehog signaling pathway hsa04350 TGF-beta signaling pathway hsa04370 VEGF signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04520 Adherens junction hsa04630 JAK-STAT signaling pathway hsa04915 Estrogen signaling pathway KO_PATHWAY ko05200 ///