ENTRY hsa05130 Pathway NAME Pathogenic Escherichia coli infection - Homo sapiens (human) DESCRIPTION Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells. CLASS Human Diseases; Infectious disease: bacterial PATHWAY_MAP hsa05130 Pathogenic Escherichia coli infection NETWORK nt06180 Pathogenic Escherichia coli nt06182 Shigella nt06516 TNF signaling nt06517 TLR signaling nt06521 NLR signaling nt06524 Apoptosis ELEMENT N00926 Escherichia Tir to TLR2/4-MAPK signaling pathway N00927 Escherichia/Shigella NleE/OspZ to TNF-NFKB signaling pathway N00928 Escherichia NleB to TNF-NFKB signaling pathway N00929 Escherichia NleC to TNF-NFKB signaling pathway N00930 Escherichia NleD to TNF-JNK signaling pathway N00931 Escherichia NleD to TNF-p38 signaling pathway N00932 Escherichia NleH1 to TNF-NFKB signaling pathway N00933 Escherichia NleA to NLRP3 inflammasome signaling pathway N00935 Escherichia NleF to non-canonical inflammasome signaling pathway N00936 Escherichia NleB1 to crosstalk between extrinsic and intrinsic apoptotic pathways N00937 Escherichia NleF to extrinsic apoptotic pathway N00938 Escherichia NleH to intrinsic apoptotic pathway N00939 Escherichia EspF to intrinsic apoptotic pathway N01084 Escherichia EspG to ARNO-ARF-ACTB/G signaling pathway N01085 Escherichia EspG to ARNO-ARF-ACTB/G signaling pathway N01086 Escherichia EspT to RAC signaling pathway N01087 Escherichia EspW to RAC signaling pathway N01088 Escherichia EspH to LPA-GNA12/13-RhoA signaling pathway N01089 Escherichia EspM to LPA-GNA12/13-Rho signaling pathway N01091 Escherichia EspJ to IGG-FCGR-RAC signaling pathway N01092 Escherichia Eae/Tir to Actin signaling pathway N01093 Escherichia EspJ/Tir to Actin signaling pathway N01094 Escherichia Eae/Tir/TccP to Actin signaling pathway N01095 Escherichia Map to LPA-GNA12/13-RhoA signaling pathway N01096 Escherichia Map to CDC42 signaling pathway N01286 Escherichia EspG to Microtubule-RHOA signaling pathway N01288 Escherichia EspF to Tight junction-Actin signaling pathway N01290 Escherichia NleA to COPII vesicle formation N01292 Escherichia EspG to RAB1 signaling pathway N01294 Escherichia NleF to COPI vesicle formation DISEASE H00277 Enterohemorrhagic Escherichia coli (EHEC) infection H00278 Enteropathogenic Escherichia coli (EPEC) infection ORGANISM Homo sapiens (human) [GN:hsa] GENE 10006 ABI1; abl interactor 1 isoform a [KO:K23649] 100132463 CLDN24; claudin-24 [KO:K06087] 100288814 CLDN34; claudin-34 [KO:K06087] 100506658 OCLN; occludin isoform a [KO:K06088] 10061 ABCF2; ATP-binding cassette sub-family F member 2 [KO:K06185] 10092 ARPC5; actin-related protein 2/3 complex subunit 5 isoform 1 [KO:K05754] 10093 ARPC4; actin-related protein 2/3 complex subunit 4 isoform a [KO:K05755] 10094 ARPC3; actin-related protein 2/3 complex subunit 3 isoform 1 [KO:K05756] 10095 ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757] 10096 ACTR3; actin-related protein 3 isoform 1 [KO:K18584] 10097 ACTR2; actin-related protein 2 isoform b [KO:K17260] 10109 ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758] 10163 WASF2; actin-binding protein WASF2 isoform 1 [KO:K05748] 102723407 [KO:K06856] 10376 TUBA1B; tubulin alpha-1B chain [KO:K07374] 10381 TUBB3; tubulin beta-3 chain isoform 1 [KO:K07375] 10382 TUBB4A; tubulin beta-4A chain isoform 3 [KO:K07375] 10383 TUBB4B; tubulin beta-4B chain [KO:K07375] 10427 SEC24B; protein transport protein Sec24B isoform a [KO:K14007] 10454 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha [KO:K04403] 10458 BAIAP2; BAR/IMD domain-containing adapter protein 2 isoform 2 [KO:K05627] 10552 ARPC1A; actin-related protein 2/3 complex subunit 1A isoform 1 [KO:K05757] 10672 GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform 1 [KO:K04639] 10686 CLDN16; claudin-16 [KO:K06087] 10787 NCKAP1; nck-associated protein 1 isoform 1 [KO:K05750] 10802 SEC24A; protein transport protein Sec24A isoform 1 [KO:K14007] 10810 WASF3; actin-binding protein WASF3 isoform 1 [KO:K06083] 10972 TMED10; transmembrane emp24 domain-containing protein 10 precursor [KO:K20352] 112714 TUBA3E; tubulin alpha-3E chain [KO:K07374] 113457 TUBA3D; tubulin alpha-3D chain [KO:K07374] 114483834 ABCF2-H2BK1; ABCF2-H2B protein [KO:K06185] 114548 NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform a [KO:K12800] 114609 TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform a [KO:K05403] 1147 CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 [KO:K04467] [EC:2.7.11.10] 1364 CLDN4; claudin-4 [KO:K06087] 1365 CLDN3; claudin-3 [KO:K06087] 1366 CLDN7; claudin-7 isoform 1 [KO:K06087] 137075 CLDN23; claudin-23 [KO:K06087] 1432 MAPK14; mitogen-activated protein kinase 14 isoform 2 [KO:K04441] [EC:2.7.11.24] 147179 WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475] 147945 NLRP4; NACHT, LRR and PYD domains-containing protein 4 [KO:K22265] 149461 CLDN19; claudin-19 isoform a [KO:K06087] 1902 LPAR1; lysophosphatidic acid receptor 1 isoform a [KO:K04289] 2017 CTTN; src substrate cortactin isoform a [KO:K06106] 203068 TUBB; tubulin beta chain isoform b [KO:K07375] 2147 F2; prothrombin preproprotein [KO:K01313] [EC:3.4.21.5] 2149 F2R; proteinase-activated receptor 1 isoform 1 precursor [KO:K03914] 2212 FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor [KO:K06472] 23118 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a [KO:K04404] 23191 CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform a [KO:K05749] 23365 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform 1 [KO:K07532] 2353 FOS; protein c-Fos [KO:K04379] 23562 CLDN14; claudin-14 [KO:K06087] 24146 CLDN15; claudin-15 [KO:K06087] 25 ABL1; tyrosine-protein kinase ABL1 isoform a [KO:K06619] [EC:2.7.10.2] 2534 FYN; tyrosine-protein kinase Fyn isoform a [KO:K05703] [EC:2.7.10.2] 257397 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 1 [KO:K12793] 2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase isoform 1 [KO:K00134] [EC:1.2.1.12] 260334 TUBB8B; tubulin beta 8B isoform 1 [KO:K07375] 26285 CLDN17; claudin-17 [KO:K06087] 26999 CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform c [KO:K05749] 27128 CYTH4; cytohesin-4 isoform 1 [KO:K18441] 2768 GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform 1 [KO:K04346] 283446 MYO1H; unconventional myosin-Ih [KO:K10356] 2846 LPAR4; lysophosphatidic acid receptor 4 [KO:K04275] 29108 PYCARD; apoptosis-associated speck-like protein containing a CARD isoform a [KO:K12799] 3059 HCLS1; hematopoietic lineage cell-specific protein isoform 1 [KO:K06106] 3071 NCKAP1L; nck-associated protein 1-like isoform 1 [KO:K05750] 347688 TUBB8; tubulin beta-8 chain isoform 1 [KO:K07375] 347733 TUBB2B; tubulin beta-2B chain [KO:K07375] 355 FAS; tumor necrosis factor receptor superfamily member 6 isoform 1 precursor [KO:K04390] 3551 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1 [KO:K07209] [EC:2.7.11.10] 3553 IL1B; interleukin-1 beta proprotein [KO:K04519] 3554 IL1R1; interleukin-1 receptor type 1 isoform 1 precursor [KO:K04386] 356 FASLG; tumor necrosis factor ligand superfamily member 6 isoform 1 [KO:K04389] 3569 IL6; interleukin-6 isoform 1 precursor [KO:K05405] 3576 CXCL8; interleukin-8 isoform 1 precursor [KO:K10030] 3606 IL18; interleukin-18 isoform 1 precursor [KO:K05482] 3654 IRAK1; interleukin-1 receptor-associated kinase 1 isoform 1 [KO:K04730] [EC:2.7.11.1] 3688 ITGB1; integrin beta-1 isoform 1A precursor [KO:K05719] 3725 JUN; transcription factor Jun [KO:K04448] 375 ARF1; ADP-ribosylation factor 1 [KO:K07937] 382 ARF6; ADP-ribosylation factor 6 [KO:K07941] 387 RHOA; transforming protein RhoA isoform 1 precursor [KO:K04513] 4430 MYO1B; unconventional myosin-Ib isoform 1 [KO:K10356] 4542 MYO1F; unconventional myosin-If isoform 1 [KO:K10356] 4615 MYD88; myeloid differentiation primary response protein MyD88 isoform 2 [KO:K04729] 4627 MYH9; myosin-9 [KO:K10352] 4628 MYH10; myosin-10 isoform 2 [KO:K10352] 4629 MYH11; myosin-11 isoform SM1A [KO:K10352] 4640 MYO1A; unconventional myosin-Ia [KO:K10356] 4641 MYO1C; unconventional myosin-Ic isoform a [KO:K10356] 4642 MYO1D; unconventional myosin-Id isoform 1 [KO:K10356] 4643 MYO1E; unconventional myosin-Ie [KO:K10356] 4644 MYO5A; unconventional myosin-Va isoform 1 [KO:K10357] 4645 MYO5B; unconventional myosin-Vb [KO:K10357] 4646 MYO6; unconventional myosin-VI isoform 2 [KO:K10358] 4651 MYO10; unconventional myosin-X [KO:K12559] 4671 NAIP; baculoviral IAP repeat-containing protein 1 isoform 1 [KO:K12807] 4690 NCK1; SH2/SH3 adapter protein NCK1 isoform 1 [KO:K07365] 4691 NCL; nucleolin [KO:K11294] 4790 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein [KO:K02580] 4792 NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734] 4793 NFKBIB; NF-kappa-B inhibitor beta isoform 1 [KO:K02581] 49861 CLDN20; claudin-20 precursor [KO:K06087] 5010 CLDN11; claudin-11 isoform 1 [KO:K06087] 5058 PAK1; serine/threonine-protein kinase PAK 1 isoform 2 [KO:K04409] [EC:2.7.11.1] 5062 PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1] 5063 PAK3; serine/threonine-protein kinase PAK 3 isoform d [KO:K05733] [EC:2.7.11.1] 51135 IRAK4; interleukin-1 receptor-associated kinase 4 isoform a [KO:K04733] [EC:2.7.11.1] 51208 CLDN18; claudin-18 isoform 1 [KO:K06087] 51807 TUBA8; tubulin alpha-8 chain isoform 1 [KO:K07374] 53842 CLDN22; claudin-22 [KO:K06087] 54205 CYCS; cytochrome c [KO:K08738] 55845 BRK1; protein BRICK1 [KO:K05752] 55930 MYO5C; unconventional myosin-Vc [KO:K10357] 5594 MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24] 5595 MAPK3; mitogen-activated protein kinase 3 isoform 1 [KO:K04371] [EC:2.7.11.24] 55971 BAIAP2L1; BAR/IMD domain-containing adapter protein 2-like 1 [KO:K20127] 5599 MAPK8; mitogen-activated protein kinase 8 isoform alpha2 [KO:K04440] [EC:2.7.11.24] 5600 MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24] 5601 MAPK9; mitogen-activated protein kinase 9 isoform alpha2 [KO:K04440] [EC:2.7.11.24] 5602 MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24] 5603 MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24] 57121 LPAR5; lysophosphatidic acid receptor 5 [KO:K08390] 57180 ACTR3B; actin-related protein 3B isoform 1 [KO:K18584] 5777 PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform 1 [KO:K05697] [EC:3.1.3.48] 578 BAK1; bcl-2 homologous antagonist/killer [KO:K14021] 5781 PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform 1 [KO:K07293] [EC:3.1.3.48] 581 BAX; apoptosis regulator BAX isoform alpha [KO:K02159] 5861 RAB1A; ras-related protein Rab-1A isoform 1 [KO:K07874] 5879 RAC1; ras-related C3 botulinum toxin substrate 1 isoform Rac1 [KO:K04392] 5970 RELA; transcription factor p65 isoform 1 [KO:K04735] 60 ACTB; actin, cytoplasmic 1 [KO:K05692] 6093 ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39] 6188 RPS3; small ribosomal subunit protein uS3 isoform 1 [KO:K02985] 6300 MAPK12; mitogen-activated protein kinase 12 isoform 1 [KO:K04441] [EC:2.7.11.24] 64005 MYO1G; unconventional myosin-Ig [KO:K10356] 644150 WIPF3; WAS/WASL-interacting protein family member 3 isoform 1 [KO:K19475] 644672 CLDN25; claudin-25 [KO:K06087] 653857 ACTR3C; actin-related protein 3C isoform a precursor [KO:K18584] 6714 SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2] 6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform B [KO:K04427] [EC:2.7.11.25] 7009 TMBIM6; bax inhibitor 1 isoform 1 [KO:K21889] 7082 TJP1; tight junction protein 1 isoform a [KO:K05701] 7099 TLR4; toll-like receptor 4 isoform A precursor [KO:K10160] 71 ACTG1; actin, cytoplasmic 2 [KO:K05692] 7100 TLR5; toll-like receptor 5 precursor [KO:K10168] 7122 CLDN5; claudin-5 isoform 2 [KO:K06087] 7124 TNF; tumor necrosis factor [KO:K03156] 7132 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform 1 precursor [KO:K03158] 7186 TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27] 7189 TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27] 7277 TUBA4A; tubulin alpha-4A chain isoform 1 [KO:K07374] 7278 TUBA3C; tubulin alpha-3C chain [KO:K07374] 7280 TUBB2A; tubulin beta-2A chain isoform 1 [KO:K07375] 7430 EZR; ezrin [KO:K08007] 7456 WIPF1; WAS/WASL-interacting protein family member 1 isoform a [KO:K19475] 7846 TUBA1A; tubulin alpha-1A chain isoform 1 [KO:K07374] 79784 MYH14; myosin-14 isoform 2 [KO:K10352] 79861 TUBAL3; tubulin alpha chain-like 3 isoform 1 [KO:K07374] 81027 TUBB1; tubulin beta-1 chain [KO:K07375] 81873 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754] 834 CASP1; caspase-1 isoform alpha precursor [KO:K01370] [EC:3.4.22.36] 836 CASP3; caspase-3 isoform a preproprotein [KO:K02187] [EC:3.4.22.56] 837 CASP4; caspase-4 isoform alpha precursor [KO:K04394] [EC:3.4.22.57 3.4.22.64] 840 CASP7; caspase-7 isoform alpha precursor [KO:K04397] [EC:3.4.22.60] 841 CASP8; caspase-8 isoform 2 precursor [KO:K04398] [EC:3.4.22.61] 842 CASP9; caspase-9 isoform alpha precursor [KO:K04399] [EC:3.4.22.62] 8440 NCK2; cytoplasmic protein NCK2 isoform A [KO:K19862] 84617 TUBB6; tubulin beta-6 chain isoform 1 [KO:K07375] 84790 TUBA1C; tubulin alpha-1C chain isoform c [KO:K07374] 8517 IKBKG; NF-kappa-B essential modulator isoform a [KO:K07210] 8717 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171] 8737 RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform 1 [KO:K02861] [EC:2.7.11.1] 8743 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform 1 [KO:K04721] 8772 FADD; FAS-associated death domain protein [KO:K02373] 8795 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [KO:K04722] 8797 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722] 8936 WASF1; actin-binding protein WASF1 [KO:K05753] 8976 WASL; actin nucleation-promoting factor WASL [KO:K23612] 9069 CLDN12; claudin-12 [KO:K06087] 9071 CLDN10; claudin-10 isoform b [KO:K06087] 9073 CLDN8; claudin-8 [KO:K06087] 9074 CLDN6; claudin-6 [KO:K06087] 9075 CLDN2; claudin-2 [KO:K06087] 9076 CLDN1; claudin-1 [KO:K06087] 9080 CLDN9; claudin-9 [KO:K06087] 9138 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform 2 [KO:K12330] 9170 LPAR2; lysophosphatidic acid receptor 2 [KO:K04291] 9181 ARHGEF2; rho guanine nucleotide exchange factor 2 isoform 1 [KO:K12791] 9265 CYTH3; cytohesin-3 isoform b [KO:K18441] 9266 CYTH2; cytohesin-2 isoform 1 [KO:K18441] 9267 CYTH1; cytohesin-1 isoform 1 [KO:K18441] 9368 NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365] 9475 ROCK2; rho-associated protein kinase 2 isoform 1 [KO:K17388] [EC:2.7.11.39] 9632 SEC24C; protein transport protein Sec24C [KO:K14007] 9826 ARHGEF11; rho guanine nucleotide exchange factor 11 isoform 1 [KO:K12331] 9871 SEC24D; protein transport protein Sec24D isoform 1 [KO:K14007] 998 CDC42; cell division control protein 42 homolog isoform 1 precursor [KO:K04393] COMPOUND C00338 Lipopolysaccharide C00350 Phosphatidylethanolamine C00681 1-Acyl-sn-glycerol 3-phosphate REFERENCE PMID:29477730 AUTHORS Pinaud L, Sansonetti PJ, Phalipon A TITLE Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors. JOURNAL Trends Microbiol 26:266-283 (2018) DOI:10.1016/j.tim.2018.01.010 REFERENCE PMID:25588886 AUTHORS Santos AS, Finlay BB TITLE Bringing down the host: enteropathogenic and enterohaemorrhagic Escherichia coli effector-mediated subversion of host innate immune pathways. JOURNAL Cell Microbiol 17:318-32 (2015) DOI:10.1111/cmi.12412 REFERENCE PMID:26104206 AUTHORS Pearson JS, Hartland EL TITLE The Inflammatory Response during Enterohemorrhagic Escherichia coli Infection. JOURNAL Microbiol Spectr 2:EHEC-0012-2013 (2014) DOI:10.1128/microbiolspec.EHEC-0012-2013 REFERENCE PMID:21488979 AUTHORS Wong AR, Pearson JS, Bright MD, Munera D, Robinson KS, Lee SF, Frankel G, Hartland EL TITLE Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements. JOURNAL Mol Microbiol 80:1420-38 (2011) DOI:10.1111/j.1365-2958.2011.07661.x REFERENCE PMID:23927593 AUTHORS Lai Y, Rosenshine I, Leong JM, Frankel G TITLE Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli. JOURNAL Cell Microbiol 15:1796-808 (2013) DOI:10.1111/cmi.12179 REFERENCE PMID:27606286 AUTHORS Ugalde-Silva P, Gonzalez-Lugo O, Navarro-Garcia F TITLE Tight Junction Disruption Induced by Type 3 Secretion System Effectors Injected by Enteropathogenic and Enterohemorrhagic Escherichia coli. JOURNAL Front Cell Infect Microbiol 6:87 (2016) DOI:10.3389/fcimb.2016.00087 REFERENCE PMID:27617233 AUTHORS Yen H, Karino M, Tobe T TITLE Modulation of the Inflammasome Signaling Pathway by Enteropathogenic and Enterohemorrhagic Escherichia coli. JOURNAL Front Cell Infect Microbiol 6:89 (2016) DOI:10.3389/fcimb.2016.00089 REFERENCE PMID:27732847 AUTHORS Humphreys D, Singh V, Koronakis V TITLE Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis. JOURNAL Cell Rep 17:697-707 (2016) DOI:10.1016/j.celrep.2016.09.039 REFERENCE PMID:20300064 AUTHORS Dong N, Liu L, Shao F TITLE A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis. JOURNAL EMBO J 29:1363-76 (2010) DOI:10.1038/emboj.2010.33 REFERENCE PMID:15318166 AUTHORS Matsuzawa T, Kuwae A, Yoshida S, Sasakawa C, Abe A. TITLE Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1. JOURNAL EMBO J 23:3570-82 (2004) DOI:10.1038/sj.emboj.7600359 REL_PATHWAY hsa04064 NF-kappa B signaling pathway hsa04210 Apoptosis hsa04530 Tight junction hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04666 Fc gamma R-mediated phagosome formation hsa04810 Regulation of actin cytoskeleton KO_PATHWAY ko05130 ///