ENTRY hsa04810 Pathway NAME Regulation of actin cytoskeleton - Homo sapiens (human) CLASS Cellular Processes; Cell motility PATHWAY_MAP hsa04810 Regulation of actin cytoskeleton NETWORK nt06167 Human cytomegalovirus (HCMV) nt06180 Pathogenic Escherichia coli nt06181 Salmonella nt06182 Shigella nt06183 Yersinia nt06464 Amyotrophic lateral sclerosis nt06533 Chemokine signaling nt06541 Cytoskeleton in neurons ELEMENT N00405 CXCR4-GNA12/13-Rho signaling pathway N01068 ITGA/B-FAK-RAC signaling pathway N01097 LPA-GNA12/13-RhoA signaling pathway N01161 Actin polymerization N01768 CXCR4-GNA12/13 signaling pathway DRUG D01175 Carpronium chloride (JAN/INN) D01840 Fasudil hydrochloride (JAN) D03065 Becaplermin (USAN/INN) D03115 Fasudil hydrochloride hydrate (JAN) D03497 Cilengitide (USAN/INN) D04492 Icatibant acetate (JAN/USAN) D05338 Palifermin (USAN/INN) D05716 Repifermin (USAN/INN) D06319 Volociximab (USAN) D07941 Fasudil (INN) D09342 Etaracizumab (USAN/INN) D09752 Carpronium chloride hydrate (JAN) D10028 Valategrast hydrochloride (USAN) D10374 Lifitegrast (USAN/INN) D10392 Lifitegrast sodium (USAN) D10463 Ripasudil hydrochloride hydrate (JAN/USAN) D12722 Bexotegrast (USAN/INN) D13006 Sigvotatug (USAN/INN) D13014 Ripasudil (USAN/INN) DBLINKS GO: 0030036 ORGANISM Homo sapiens (human) [GN:hsa] GENE 10000 AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1] 10092 ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754] 10093 ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755] 10094 ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756] 10095 ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757] 10096 ACTR3; actin related protein 3 [KO:K18584] 10097 ACTR2; actin related protein 2 [KO:K17260] 10109 ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758] 10152 ABI2; abl interactor 2 [KO:K05751] 10163 WASF2; WASP family member 2 [KO:K05748] 10297 APC2; APC regulator of WNT signaling pathway 2 [KO:K02085] 10298 PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1] 103910 MYL12B; myosin light chain 12B [KO:K12757] 10398 MYL9; myosin light chain 9 [KO:K12755] 10451 VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730] 10458 BAIAP2; BAR/IMD domain containing adaptor protein 2 [KO:K05627] 10552 ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757] 10627 MYL12A; myosin light chain 12A [KO:K12757] 10672 GNA13; G protein subunit alpha 13 [KO:K04639] 106821730 BUB1B-PAK6; BUB1B-PAK6 readthrough [KO:K05735] [EC:2.7.11.1] 1072 CFL1; cofilin 1 [KO:K05765] 1073 CFL2; cofilin 2 [KO:K05765] 10787 NCKAP1; NCK associated protein 1 [KO:K05750] 10788 IQGAP2; IQ motif containing GTPase activating protein 2 [KO:K05767] 110117499 P3R3URF-PIK3R3; P3R3URF-PIK3R3 readthrough [KO:K02649] 1128 CHRM1; cholinergic receptor muscarinic 1 [KO:K04129] 1129 CHRM2; cholinergic receptor muscarinic 2 [KO:K04130] 1131 CHRM3; cholinergic receptor muscarinic 3 [KO:K04131] 1132 CHRM4; cholinergic receptor muscarinic 4 [KO:K04132] 1133 CHRM5; cholinergic receptor muscarinic 5 [KO:K04133] 128239 IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767] 1398 CRK; CRK proto-oncogene, adaptor protein [KO:K04438] 1399 CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438] 1729 DIAPH1; diaphanous related formin 1 [KO:K05740] 1730 DIAPH2; diaphanous related formin 2 [KO:K05741] 1793 DOCK1; dedicator of cytokinesis 1 [KO:K13708] 1902 LPAR1; lysophosphatidic acid receptor 1 [KO:K04289] 1950 EGF; epidermal growth factor [KO:K04357] 1956 EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1] 200576 PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150] 207 AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1] 208 AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1] 2147 F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5] 2149 F2R; coagulation factor II thrombin receptor [KO:K03914] 221178 SPATA13; spermatogenesis associated 13 [KO:K05769] 2245 FGD1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720] 2246 FGF1; fibroblast growth factor 1 [KO:K18496] 2247 FGF2; fibroblast growth factor 2 [KO:K18497] 2248 FGF3; fibroblast growth factor 3 [KO:K04358] 2249 FGF4; fibroblast growth factor 4 [KO:K04358] 2250 FGF5; fibroblast growth factor 5 [KO:K04358] 2251 FGF6; fibroblast growth factor 6 [KO:K04358] 2252 FGF7; fibroblast growth factor 7 [KO:K04358] 2253 FGF8; fibroblast growth factor 8 [KO:K04358] 2254 FGF9; fibroblast growth factor 9 [KO:K04358] 2255 FGF10; fibroblast growth factor 10 [KO:K04358] 2260 FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1] 2261 FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1] 2263 FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1] 2264 FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1] 22800 RRAS2; RAS related 2 [KO:K07830] 22801 ITGA11; integrin subunit alpha 11 [KO:K06587] 22808 MRAS; muscle RAS oncogene homolog [KO:K07831] 23191 CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749] 2335 FN1; fibronectin 1 [KO:K05717] 23365 ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532] 23396 PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68] 26281 FGF20; fibroblast growth factor 20 [KO:K04358] 26291 FGF21; fibroblast growth factor 21 [KO:K22429] 26999 CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749] 27006 FGF22; fibroblast growth factor 22 [KO:K04358] 2768 GNA12; G protein subunit alpha 12 [KO:K04346] 2846 LPAR4; lysophosphatidic acid receptor 4 [KO:K04275] 28964 GIT1; GIT ArfGAP 1 [KO:K05737] 28984 RGCC; regulator of cell cycle [KO:K26108] 2909 ARHGAP35; Rho GTPase activating protein 35 [KO:K05732] 2934 GSN; gelsolin [KO:K05768] 29895 MYL11; myosin light chain 11 [KO:K12758] 3071 NCKAP1L; NCK associated protein 1 like [KO:K05750] 324 APC; APC regulator of WNT signaling pathway [KO:K02085] 3265 HRAS; HRas proto-oncogene, GTPase [KO:K02833] 340156 MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18] 345456 PFN3; profilin 3 [KO:K05759] 3630 INS; insulin [KO:K04526] 3645 INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1] 3655 ITGA6; integrin subunit alpha 6 [KO:K06485] 3672 ITGA1; integrin subunit alpha 1 [KO:K06480] 3673 ITGA2; integrin subunit alpha 2 [KO:K06481] 3674 ITGA2B; integrin subunit alpha 2b [KO:K06476] 3675 ITGA3; integrin subunit alpha 3 [KO:K06482] 3676 ITGA4; integrin subunit alpha 4 [KO:K06483] 3678 ITGA5; integrin subunit alpha 5 [KO:K06484] 3679 ITGA7; integrin subunit alpha 7 [KO:K06583] 3680 ITGA9; integrin subunit alpha 9 [KO:K06585] 3681 ITGAD; integrin subunit alpha D [KO:K06594] 3682 ITGAE; integrin subunit alpha E [KO:K06524] 3683 ITGAL; integrin subunit alpha L [KO:K05718] 3684 ITGAM; integrin subunit alpha M [KO:K06461] 3685 ITGAV; integrin subunit alpha V [KO:K06487] 3687 ITGAX; integrin subunit alpha X [KO:K06462] 3688 ITGB1; integrin subunit beta 1 [KO:K05719] 3689 ITGB2; integrin subunit beta 2 [KO:K06464] 369 ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1] 3690 ITGB3; integrin subunit beta 3 [KO:K06493] 3691 ITGB4; integrin subunit beta 4 [KO:K06525] 3693 ITGB5; integrin subunit beta 5 [KO:K06588] 3694 ITGB6; integrin subunit beta 6 [KO:K06589] 3695 ITGB7; integrin subunit beta 7 [KO:K06590] 3696 ITGB8; integrin subunit beta 8 [KO:K06591] 375189 PFN4; profilin family member 4 [KO:K05759] 3827 KNG1; kininogen 1 [KO:K03898] 3845 KRAS; KRAS proto-oncogene, GTPase [KO:K07827] 387 RHOA; ras homolog family member A [KO:K04513] 3984 LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1] 3985 LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1] 4342 MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1] 4478 MSN; moesin [KO:K05763] 4627 MYH9; myosin heavy chain 9 [KO:K10352] 4628 MYH10; myosin heavy chain 10 [KO:K10352] 4629 MYH11; myosin heavy chain 11 [KO:K10352] 4633 MYL2; myosin light chain 2 [KO:K10351] 4636 MYL5; myosin light chain 5 [KO:K12753] 4638 MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18] 4659 PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270] 4660 PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329] 4893 NRAS; NRAS proto-oncogene, GTPase [KO:K07828] 5058 PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1] 5062 PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1] 5063 PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1] 50649 ARHGEF4; Rho guanine nucleotide exchange factor 4 [KO:K05769] 5154 PDGFA; platelet derived growth factor subunit A [KO:K04359] 5155 PDGFB; platelet derived growth factor subunit B [KO:K17386] 5156 PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1] 51571 CYRIB; CYFIP related Rac1 interactor B [KO:K27976] 5159 PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1] 5216 PFN1; profilin 1 [KO:K05759] 5217 PFN2; profilin 2 [KO:K05759] 5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153] 5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153] 5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153] 5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649] 5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649] 5305 PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149] 54434 SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48] 54776 PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457] 54961 SSH3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48] 5499 PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16] 5500 PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16] 5501 PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16] 55740 ENAH; ENAH actin regulator [KO:K05746] 55845 BRK1; BRICK1 subunit of SCAR/WAVE actin nucleating complex [KO:K05752] 5594 MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24] 5595 MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24] 55970 GNG12; G protein subunit gamma 12 [KO:K04347] 56034 PDGFC; platelet derived growth factor C [KO:K05450] 5604 MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2] 5605 MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2] 56924 PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1] 57121 LPAR5; lysophosphatidic acid receptor 5 [KO:K08390] 57144 PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1] 57180 ACTR3B; actin related protein 3B [KO:K18584] 5747 PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2] 5829 PXN; paxillin [KO:K05760] 58498 MYL7; myosin light chain 7 [KO:K12754] 5879 RAC1; Rac family small GTPase 1 [KO:K04392] 5880 RAC2; Rac family small GTPase 2 [KO:K07860] 5881 RAC3; Rac family small GTPase 3 [KO:K07861] 5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1] 5962 RDX; radixin [KO:K05762] 60 ACTB; actin beta [KO:K05692] 6093 ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39] 623 BDKRB1; bradykinin receptor B1 [KO:K03915] 6237 RRAS; RAS related [KO:K07829] 624 BDKRB2; bradykinin receptor B2 [KO:K03916] 6387 CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031] 653857 ACTR3C; actin related protein 3C [KO:K18584] 6548 SLC9A1; solute carrier family 9 member A1 [KO:K05742] 6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099] 6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099] 6714 SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2] 673 BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1] 7074 TIAM1; TIAM Rac1 associated GEF 1 [KO:K05731] 71 ACTG1; actin gamma 1 [KO:K05692] 7114 TMSB4X; thymosin beta 4 X-linked [KO:K05764] 727 C5; complement C5 [KO:K03994] 729 C6; complement C6 [KO:K03995] 730 C7; complement C7 [KO:K03996] 731 C8A; complement C8 alpha chain [KO:K03997] 732 C8B; complement C8 beta chain [KO:K03998] 733 C8G; complement C8 gamma chain [KO:K03999] 735 C9; complement C9 [KO:K04000] 7409 VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730] 7410 VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730] 7414 VCL; vinculin [KO:K05700] 7430 EZR; ezrin [KO:K08007] 7852 CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189] 79784 MYH14; myosin heavy chain 14 [KO:K10352] 79837 PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149] 80310 PDGFD; platelet derived growth factor D [KO:K05450] 8074 FGF23; fibroblast growth factor 23 [KO:K22428] 81 ACTN4; actinin alpha 4 [KO:K05699] 81553 CYRIA; CYFIP related Rac1 interactor A [KO:K27976] 81624 DIAPH3; diaphanous related formin 3 [KO:K05745] 81873 ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754] 8394 PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68] 8395 PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68] 8396 PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149] 8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649] 8515 ITGA10; integrin subunit alpha 10 [KO:K06586] 8516 ITGA8; integrin subunit alpha 8 [KO:K06584] 85366 MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18] 85464 SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48] 85477 SCIN; scinderin [KO:K05768] 87 ACTN1; actinin alpha 1 [KO:K05699] 8817 FGF18; fibroblast growth factor 18 [KO:K04358] 8822 FGF17; fibroblast growth factor 17 [KO:K04358] 8823 FGF16; fibroblast growth factor 16 [KO:K04358] 8826 IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848] 8874 ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710] 8936 WASF1; WASP family member 1 [KO:K05753] 8976 WASL; WASP like actin nucleation promoting factor [KO:K23612] 89846 FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722] 9087 TMSB4Y; thymosin beta 4 Y-linked [KO:K05764] 9138 ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330] 9170 LPAR2; lysophosphatidic acid receptor 2 [KO:K04291] 91807 MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18] 93408 MYL10; myosin light chain 10 [KO:K12756] 9459 ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729] 9475 ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39] 9564 BCAR1; BCAR1 scaffold protein, Cas family member [KO:K05726] 9965 FGF19; fibroblast growth factor 19 [KO:K22603] 998 CDC42; cell division cycle 42 [KO:K04393] COMPOUND C00681 1-Acyl-sn-glycerol 3-phosphate C01996 Acetylcholine C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate C05981 Phosphatidylinositol-3,4,5-trisphosphate C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate REFERENCE PMID:14744429 AUTHORS Burridge K, Wennerberg K. TITLE Rho and Rac take center stage. JOURNAL Cell 116:167-79 (2004) DOI:10.1016/S0092-8674(04)00003-0 REFERENCE PMID:11082269 AUTHORS Schmitz AA, Govek EE, Bottner B, Van Aelst L. TITLE Rho GTPases: signaling, migration, and invasion. JOURNAL Exp Cell Res 261:1-12 (2000) DOI:10.1006/excr.2000.5049 REFERENCE PMID:11152757 AUTHORS Takai Y, Sasaki T, Matozaki T. TITLE Small GTP-binding proteins. JOURNAL Physiol Rev 81:153-208 (2001) DOI:10.1152/physrev.2001.81.1.153 REFERENCE PMID:12700767 AUTHORS Pollard TD. TITLE The cytoskeleton, cellular motility and the reductionist agenda. JOURNAL Nature 422:741-5 (2003) DOI:10.1038/nature01598 REFERENCE PMID:14657486 AUTHORS Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. TITLE Cell migration: integrating signals from front to back. JOURNAL Science 302:1704-9 (2003) DOI:10.1126/science.1092053 REFERENCE PMID:11082272 AUTHORS Sastry SK, Burridge K. TITLE Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. JOURNAL Exp Cell Res 261:25-36 (2000) DOI:10.1006/excr.2000.5043 REFERENCE PMID:10574699 AUTHORS Fukata M, Nakagawa M, Kuroda S, Kaibuchi K. TITLE Cell adhesion and Rho small GTPases. JOURNAL J Cell Sci 112 ( Pt 24):4491-500 (1999) REL_PATHWAY hsa04010 MAPK signaling pathway hsa04510 Focal adhesion hsa04520 Adherens junction KO_PATHWAY ko04810 ///