ENTRY hsa04810 Pathway NAME Regulation of actin cytoskeleton - Homo sapiens (human) CLASS Cellular Processes; Cell motility PATHWAY_MAP hsa04810 Regulation of actin cytoskeleton NETWORK nt06167 Human cytomegalovirus (HCMV) nt06180 Pathogenic Escherichia coli nt06181 Salmonella nt06182 Shigella nt06183 Yersinia nt06464 Amyotrophic lateral sclerosis nt06541 Cytoskeleton in neurons ELEMENT N00405 CXCR4-GNA12/13-Rho signaling pathway N01068 ITGA/B-FAK-RAC signaling pathway N01097 LPA-GNA12/13-RhoA signaling pathway N01161 Actin polymerization DRUG D01175 Carpronium chloride (JAN/INN) D01840 Fasudil hydrochloride (JAN) D03065 Becaplermin (USAN/INN) D03115 Fasudil hydrochloride hydrate (JAN) D03497 Cilengitide (USAN/INN) D04492 Icatibant acetate (JAN/USAN) D05338 Palifermin (USAN/INN) D05716 Repifermin (USAN/INN) D06319 Volociximab (USAN) D07941 Fasudil (INN) D09342 Etaracizumab (USAN/INN) D09752 Carpronium chloride hydrate (JAN) D10028 Valategrast hydrochloride (USAN) D10374 Lifitegrast (USAN/INN) D10392 Lifitegrast sodium (USAN) D10463 Ripasudil hydrochloride hydrate (JAN/USAN) D12722 Bexotegrast (USAN/INN) D13006 Sigvotatug (USAN/INN) D13014 Ripasudil (USAN/INN) DBLINKS GO: 0030036 ORGANISM Homo sapiens (human) [GN:hsa] GENE 10000 AKT3; RAC-gamma serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1] 10092 ARPC5; actin-related protein 2/3 complex subunit 5 isoform 1 [KO:K05754] 10093 ARPC4; actin-related protein 2/3 complex subunit 4 isoform a [KO:K05755] 10094 ARPC3; actin-related protein 2/3 complex subunit 3 isoform 1 [KO:K05756] 10095 ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757] 10096 ACTR3; actin-related protein 3 isoform 1 [KO:K18584] 10097 ACTR2; actin-related protein 2 isoform b [KO:K17260] 10109 ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758] 10152 ABI2; abl interactor 2 isoform d [KO:K05751] 10163 WASF2; actin-binding protein WASF2 isoform 1 [KO:K05748] 10297 APC2; adenomatous polyposis coli protein 2 isoform 1 [KO:K02085] 10298 PAK4; serine/threonine-protein kinase PAK 4 isoform 1 [KO:K05734] [EC:2.7.11.1] 103910 MYL12B; myosin regulatory light chain 12B [KO:K12757] 10398 MYL9; myosin regulatory light polypeptide 9 isoform a [KO:K12755] 10451 VAV3; guanine nucleotide exchange factor VAV3 isoform 1 [KO:K05730] 10458 BAIAP2; BAR/IMD domain-containing adapter protein 2 isoform 2 [KO:K05627] 10552 ARPC1A; actin-related protein 2/3 complex subunit 1A isoform 1 [KO:K05757] 10627 MYL12A; myosin regulatory light chain 12A isoform 1 [KO:K12757] 10672 GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform 1 [KO:K04639] 106821730 BUB1B-PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1] 1072 CFL1; cofilin-1 [KO:K05765] 1073 CFL2; cofilin-2 isoform 1 [KO:K05765] 10787 NCKAP1; nck-associated protein 1 isoform 1 [KO:K05750] 10788 IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform 1 [KO:K05767] 110117499 P3R3URF-PIK3R3; LOC110117498-PIK3R3 readthrough [KO:K02649] 1128 CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129] 1129 CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130] 1131 CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131] 1132 CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132] 1133 CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133] 128239 IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767] 1398 CRK; adapter molecule crk isoform a [KO:K04438] 1399 CRKL; crk-like protein [KO:K04438] 1729 DIAPH1; protein diaphanous homolog 1 isoform 1 [KO:K05740] 1730 DIAPH2; protein diaphanous homolog 2 isoform 156 [KO:K05741] 1793 DOCK1; dedicator of cytokinesis protein 1 isoform 2 [KO:K13708] 1902 LPAR1; lysophosphatidic acid receptor 1 isoform a [KO:K04289] 1950 EGF; pro-epidermal growth factor isoform 1 preproprotein [KO:K04357] 1956 EGFR; epidermal growth factor receptor isoform a precursor [KO:K04361] [EC:2.7.10.1] 200576 PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform 2 [KO:K00921] [EC:2.7.1.150] 207 AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1] 208 AKT2; RAC-beta serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1] 2147 F2; prothrombin preproprotein [KO:K01313] [EC:3.4.21.5] 2149 F2R; proteinase-activated receptor 1 isoform 1 precursor [KO:K03914] 221178 SPATA13; spermatogenesis-associated protein 13 isoform 2 [KO:K05769] 2245 FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720] 2246 FGF1; fibroblast growth factor 1 isoform 1 precursor [KO:K18496] 2247 FGF2; fibroblast growth factor 2 isoform 34 kDa [KO:K18497] 2248 FGF3; fibroblast growth factor 3 precursor [KO:K04358] 2249 FGF4; fibroblast growth factor 4 precursor [KO:K04358] 2250 FGF5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358] 2251 FGF6; fibroblast growth factor 6 precursor [KO:K04358] 2252 FGF7; fibroblast growth factor 7 precursor [KO:K04358] 2253 FGF8; fibroblast growth factor 8 isoform E precursor [KO:K04358] 2254 FGF9; fibroblast growth factor 9 precursor [KO:K04358] 2255 FGF10; fibroblast growth factor 10 precursor [KO:K04358] 2260 FGFR1; fibroblast growth factor receptor 1 isoform 1 precursor [KO:K04362] [EC:2.7.10.1] 2261 FGFR3; fibroblast growth factor receptor 3 isoform 1 precursor [KO:K05094] [EC:2.7.10.1] 2263 FGFR2; fibroblast growth factor receptor 2 isoform 1 precursor [KO:K05093] [EC:2.7.10.1] 2264 FGFR4; fibroblast growth factor receptor 4 isoform 1 precursor [KO:K05095] [EC:2.7.10.1] 22800 RRAS2; ras-related protein R-Ras2 isoform a [KO:K07830] 22801 ITGA11; integrin alpha-11 precursor [KO:K06587] 22808 MRAS; ras-related protein M-Ras isoform 1 precursor [KO:K07831] 23191 CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform a [KO:K05749] 2335 FN1; fibronectin isoform 1 precursor [KO:K05717] 23365 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform 1 [KO:K07532] 23396 PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 2 [KO:K00889] [EC:2.7.1.68] 26281 FGF20; fibroblast growth factor 20 [KO:K04358] 26291 FGF21; fibroblast growth factor 21 precursor [KO:K22429] 26999 CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform c [KO:K05749] 27006 FGF22; fibroblast growth factor 22 isoform 1 precursor [KO:K04358] 2768 GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform 1 [KO:K04346] 2846 LPAR4; lysophosphatidic acid receptor 4 [KO:K04275] 28964 GIT1; ARF GTPase-activating protein GIT1 isoform 2 [KO:K05737] 28984 RGCC; regulator of cell cycle RGCC [KO:K26108] 2909 ARHGAP35; rho GTPase-activating protein 35 [KO:K05732] 2934 GSN; gelsolin isoform a precursor [KO:K05768] 29895 MYL11; myosin regulatory light chain 11 [KO:K12758] 3071 NCKAP1L; nck-associated protein 1-like isoform 1 [KO:K05750] 324 APC; adenomatous polyposis coli protein isoform b [KO:K02085] 3265 HRAS; GTPase HRas isoform 1 [KO:K02833] 340156 MYLK4; myosin light chain kinase family member 4 isoform 1 [KO:K00907] [EC:2.7.11.18] 345456 PFN3; profilin-3 [KO:K05759] 3630 INS; insulin preproprotein [KO:K04526] 3645 INSRR; insulin receptor-related protein precursor [KO:K05086] [EC:2.7.10.1] 3655 ITGA6; integrin alpha-6 isoform 6 precursor [KO:K06485] 3672 ITGA1; integrin alpha-1 precursor [KO:K06480] 3673 ITGA2; integrin alpha-2 precursor [KO:K06481] 3674 ITGA2B; integrin alpha-IIb preproprotein [KO:K06476] 3675 ITGA3; integrin alpha-3 preproprotein [KO:K06482] 3676 ITGA4; integrin alpha-4 isoform 1 preproprotein [KO:K06483] 3678 ITGA5; integrin alpha-5 precursor [KO:K06484] 3679 ITGA7; integrin alpha-7 isoform 7 precursor [KO:K06583] 3680 ITGA9; integrin alpha-9 precursor [KO:K06585] 3681 ITGAD; integrin alpha-D isoform 2 precursor [KO:K06594] 3682 ITGAE; integrin alpha-E isoform 1 precursor [KO:K06524] 3683 ITGAL; integrin alpha-L isoform a precursor [KO:K05718] 3684 ITGAM; integrin alpha-M isoform 2 precursor [KO:K06461] 3685 ITGAV; integrin alpha-V isoform 1 preproprotein [KO:K06487] 3687 ITGAX; integrin alpha-X isoform 2 precursor [KO:K06462] 3688 ITGB1; integrin beta-1 isoform 1A precursor [KO:K05719] 3689 ITGB2; integrin beta-2 isoform 1 precursor [KO:K06464] 369 ARAF; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:2.7.11.1] 3690 ITGB3; integrin beta-3 precursor [KO:K06493] 3691 ITGB4; integrin beta-4 isoform 1 precursor [KO:K06525] 3693 ITGB5; integrin beta-5 isoform a precursor [KO:K06588] 3694 ITGB6; integrin beta-6 isoform a precursor [KO:K06589] 3695 ITGB7; integrin beta-7 isoform a precursor [KO:K06590] 3696 ITGB8; integrin beta-8 precursor [KO:K06591] 375189 PFN4; profilin-4 [KO:K05759] 3827 KNG1; kininogen-1 isoform 1 precursor [KO:K03898] 3845 KRAS; GTPase KRas isoform a [KO:K07827] 387 RHOA; transforming protein RhoA isoform 1 precursor [KO:K04513] 3984 LIMK1; LIM domain kinase 1 isoform 1 [KO:K05743] [EC:2.7.11.1] 3985 LIMK2; LIM domain kinase 2 isoform 2a [KO:K05744] [EC:2.7.11.1] 4342 MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1] 4478 MSN; moesin isoform 1 [KO:K05763] 4627 MYH9; myosin-9 [KO:K10352] 4628 MYH10; myosin-10 isoform 2 [KO:K10352] 4629 MYH11; myosin-11 isoform SM1A [KO:K10352] 4633 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 1 [KO:K10351] 4636 MYL5; myosin light chain 5 isoform 1 [KO:K12753] 4638 MYLK; myosin light chain kinase, smooth muscle isoform 1 [KO:K00907] [EC:2.7.11.18] 4659 PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform a [KO:K06270] 4660 PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform a [KO:K12329] 4893 NRAS; GTPase NRas [KO:K07828] 5058 PAK1; serine/threonine-protein kinase PAK 1 isoform 2 [KO:K04409] [EC:2.7.11.1] 5062 PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1] 5063 PAK3; serine/threonine-protein kinase PAK 3 isoform d [KO:K05733] [EC:2.7.11.1] 50649 ARHGEF4; rho guanine nucleotide exchange factor 4 isoform a [KO:K05769] 5154 PDGFA; platelet-derived growth factor subunit A isoform 1 preproprotein [KO:K04359] 5155 PDGFB; platelet-derived growth factor subunit B isoform 1 preproprotein [KO:K17386] 5156 PDGFRA; platelet-derived growth factor receptor alpha isoform 1 precursor [KO:K04363] [EC:2.7.10.1] 51571 CYRIB; CYFIP-related Rac1 interactor B isoform 1 [KO:K27976] 5159 PDGFRB; platelet-derived growth factor receptor beta isoform 1 precursor [KO:K05089] [EC:2.7.10.1] 5216 PFN1; profilin-1 isoform 2 [KO:K05759] 5217 PFN2; profilin-2 isoform b [KO:K05759] 5290 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153] 5291 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1 [KO:K00922] [EC:2.7.1.153] 5293 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1 [KO:K00922] [EC:2.7.1.153] 5295 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 [KO:K02649] 5296 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649] 5305 PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 1 [KO:K00920] [EC:2.7.1.149] 54434 SSH1; protein phosphatase Slingshot homolog 1 isoform 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48] 54776 PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform a [KO:K17457] 54961 SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48] 5499 PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16] 5500 PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16] 5501 PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16] 55740 ENAH; protein enabled homolog isoform a [KO:K05746] 55845 BRK1; protein BRICK1 [KO:K05752] 5594 MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24] 5595 MAPK3; mitogen-activated protein kinase 3 isoform 1 [KO:K04371] [EC:2.7.11.24] 55970 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347] 56034 PDGFC; platelet-derived growth factor C precursor [KO:K05450] 5604 MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1 [KO:K04368] [EC:2.7.12.2] 5605 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform 1 [KO:K04369] [EC:2.7.12.2] 56924 PAK6; serine/threonine-protein kinase PAK 6 isoform 1 [KO:K05735] [EC:2.7.11.1] 57121 LPAR5; lysophosphatidic acid receptor 5 [KO:K08390] 57144 PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1] 57180 ACTR3B; actin-related protein 3B isoform 1 [KO:K18584] 5747 PTK2; focal adhesion kinase 1 isoform 1 [KO:K05725] [EC:2.7.10.2] 5829 PXN; paxillin isoform 2 [KO:K05760] 58498 MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754] 5879 RAC1; ras-related C3 botulinum toxin substrate 1 isoform Rac1 [KO:K04392] 5880 RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860] 5881 RAC3; ras-related C3 botulinum toxin substrate 3 isoform 1 [KO:K07861] 5894 RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform b [KO:K04366] [EC:2.7.11.1] 5962 RDX; radixin isoform 2 [KO:K05762] 60 ACTB; actin, cytoplasmic 1 [KO:K05692] 6093 ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39] 623 BDKRB1; B1 bradykinin receptor [KO:K03915] 6237 RRAS; ras-related protein R-Ras [KO:K07829] 624 BDKRB2; B2 bradykinin receptor [KO:K03916] 6387 CXCL12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031] 653857 ACTR3C; actin-related protein 3C isoform a precursor [KO:K18584] 6548 SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742] 6654 SOS1; son of sevenless homolog 1 isoform 1 [KO:K03099] 6655 SOS2; son of sevenless homolog 2 isoform 1 [KO:K03099] 6714 SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2] 673 BRAF; serine/threonine-protein kinase B-raf isoform 1 [KO:K04365] [EC:2.7.11.1] 7074 TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform 1 [KO:K05731] 71 ACTG1; actin, cytoplasmic 2 [KO:K05692] 7114 TMSB4X; thymosin beta-4 [KO:K05764] 727 C5; complement C5 isoform 1 preproprotein [KO:K03994] 729 C6; complement component C6 precursor [KO:K03995] 730 C7; complement component C7 precursor [KO:K03996] 731 C8A; complement component C8 alpha chain preproprotein [KO:K03997] 732 C8B; complement component C8 beta chain isoform 1 preproprotein [KO:K03998] 733 C8G; complement component C8 gamma chain precursor [KO:K03999] 735 C9; complement component C9 preproprotein [KO:K04000] 7409 VAV1; proto-oncogene vav isoform 1 [KO:K05730] 7410 VAV2; guanine nucleotide exchange factor VAV2 isoform 1 [KO:K05730] 7414 VCL; vinculin isoform meta-VCL [KO:K05700] 7430 EZR; ezrin [KO:K08007] 7852 CXCR4; C-X-C chemokine receptor type 4 isoform b [KO:K04189] 79784 MYH14; myosin-14 isoform 2 [KO:K10352] 79837 PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform a [KO:K00920] [EC:2.7.1.149] 80310 PDGFD; platelet-derived growth factor D isoform 1 precursor [KO:K05450] 8074 FGF23; fibroblast growth factor 23 precursor [KO:K22428] 81 ACTN4; alpha-actinin-4 isoform 1 [KO:K05699] 81553 CYRIA; CYFIP-related Rac1 interactor A [KO:K27976] 81624 DIAPH3; protein diaphanous homolog 3 isoform a [KO:K05745] 81873 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754] 8394 PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1 [KO:K00889] [EC:2.7.1.68] 8395 PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform 2 [KO:K00889] [EC:2.7.1.68] 8396 PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149] 8503 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1 [KO:K02649] 8515 ITGA10; integrin alpha-10 isoform 1 precursor [KO:K06586] 8516 ITGA8; integrin alpha-8 isoform 1 preproprotein [KO:K06584] 85366 MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18] 85464 SSH2; protein phosphatase Slingshot homolog 2 isoform 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48] 85477 SCIN; scinderin isoform 1 [KO:K05768] 87 ACTN1; alpha-actinin-1 isoform b [KO:K05699] 8817 FGF18; fibroblast growth factor 18 precursor [KO:K04358] 8822 FGF17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358] 8823 FGF16; fibroblast growth factor 16 [KO:K04358] 8826 IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848] 8874 ARHGEF7; rho guanine nucleotide exchange factor 7 isoform c [KO:K13710] 8936 WASF1; actin-binding protein WASF1 [KO:K05753] 8976 WASL; actin nucleation-promoting factor WASL [KO:K23612] 89846 FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform a [KO:K05722] 9087 TMSB4Y; thymosin beta-4, Y-chromosomal [KO:K05764] 9138 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform 2 [KO:K12330] 9170 LPAR2; lysophosphatidic acid receptor 2 [KO:K04291] 91807 MYLK3; myosin light chain kinase 3 isoform 1 [KO:K00907] [EC:2.7.11.18] 93408 MYL10; myosin regulatory light chain 10 [KO:K12756] 9459 ARHGEF6; rho guanine nucleotide exchange factor 6 isoform 1 [KO:K05729] 9475 ROCK2; rho-associated protein kinase 2 isoform 1 [KO:K17388] [EC:2.7.11.39] 9564 BCAR1; breast cancer anti-estrogen resistance protein 1 isoform 6 [KO:K05726] 9965 FGF19; fibroblast growth factor 19 precursor [KO:K22603] 998 CDC42; cell division control protein 42 homolog isoform 1 precursor [KO:K04393] COMPOUND C00681 1-Acyl-sn-glycerol 3-phosphate C01996 Acetylcholine C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate C05981 Phosphatidylinositol-3,4,5-trisphosphate C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate REFERENCE PMID:14744429 AUTHORS Burridge K, Wennerberg K. TITLE Rho and Rac take center stage. JOURNAL Cell 116:167-79 (2004) DOI:10.1016/S0092-8674(04)00003-0 REFERENCE PMID:11082269 AUTHORS Schmitz AA, Govek EE, Bottner B, Van Aelst L. TITLE Rho GTPases: signaling, migration, and invasion. JOURNAL Exp Cell Res 261:1-12 (2000) DOI:10.1006/excr.2000.5049 REFERENCE PMID:11152757 AUTHORS Takai Y, Sasaki T, Matozaki T. TITLE Small GTP-binding proteins. JOURNAL Physiol Rev 81:153-208 (2001) DOI:10.1152/physrev.2001.81.1.153 REFERENCE PMID:12700767 AUTHORS Pollard TD. TITLE The cytoskeleton, cellular motility and the reductionist agenda. JOURNAL Nature 422:741-5 (2003) DOI:10.1038/nature01598 REFERENCE PMID:14657486 AUTHORS Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. TITLE Cell migration: integrating signals from front to back. JOURNAL Science 302:1704-9 (2003) DOI:10.1126/science.1092053 REFERENCE PMID:11082272 AUTHORS Sastry SK, Burridge K. TITLE Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. JOURNAL Exp Cell Res 261:25-36 (2000) DOI:10.1006/excr.2000.5043 REFERENCE PMID:10574699 AUTHORS Fukata M, Nakagawa M, Kuroda S, Kaibuchi K. TITLE Cell adhesion and Rho small GTPases. JOURNAL J Cell Sci 112 ( Pt 24):4491-500 (1999) REL_PATHWAY hsa04010 MAPK signaling pathway hsa04510 Focal adhesion hsa04520 Adherens junction KO_PATHWAY ko04810 ///