ENTRY hsa00053 Pathway NAME Ascorbate and aldarate metabolism - Homo sapiens (human) CLASS Metabolism; Carbohydrate metabolism PATHWAY_MAP hsa00053 Ascorbate and aldarate metabolism DBLINKS GO: 0019852 0019577 0019572 ORGANISM Homo sapiens (human) [GN:hsa] GENE 7358 UGDH; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22] 10941 UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17] 79799 UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17] 7367 UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17] 10720 UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17] 54490 UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17] 54578 UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17] 54657 UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17] 54658 UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17] 54659 UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17] 7365 UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17] 54600 UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17] 7364 UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17] 54575 UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17] 54576 UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17] 54579 UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17] 7366 UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17] 54577 UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17] 7363 UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17] 574537 UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17] 2990 GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31] 9365 KL; klotho [KO:K14756] [EC:3.2.1.31] 55586 MIOX; myo-inositol oxygenase [KO:K00469] [EC:1.13.99.1] 10327 AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2] 9104 RGN; regucalcin [KO:K01053] [EC:3.1.1.17] 217 ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3] 224 ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3] 219 ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3] 501 ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3] 223 ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3] COMPOUND C00022 Pyruvate C00026 2-Oxoglutarate C00029 UDP-glucose C00072 Ascorbate C00096 GDP-mannose C00137 myo-Inositol C00167 UDP-glucuronate C00191 D-Glucuronate C00216 D-Arabinose C00231 D-Xylulose 5-phosphate C00259 L-Arabinose C00333 D-Galacturonate C00433 2,5-Dioxopentanoate C00545 L-Arabinonate C00558 D-Tagaturonate C00617 UDP-D-galacturonate C00618 3-Dehydro-L-gulonate C00652 D-Arabinono-1,4-lactone C00679 5-Dehydro-4-deoxy-D-glucarate C00684 2-Dehydro-3-deoxy-L-arabinonate C00800 L-Gulonate C00818 D-Glucarate C00878 D-Arabinonate C00879 D-Galactarate C01040 L-Gulono-1,4-lactone C01041 Monodehydroascorbate C01101 L-Ribulose 5-phosphate C01114 L-Arabinono-1,4-lactone C01115 L-Galactono-1,4-lactone C01146 2-Hydroxy-3-oxopropanoate C01620 Threonate C01825 L-Galactose C02280 GDP-L-galactose C02670 D-Glucuronolactone C03033 beta-D-Glucuronoside C03064 3-Dehydro-L-threonate C03289 L-xylo-Hexulonolactone C03291 L-Xylulose 5-phosphate C03826 2-Dehydro-3-deoxy-D-xylonate C03921 2-Dehydro-3-deoxy-D-glucarate C04037 1-Phospho-alpha-D-galacturonate C04575 (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate C05385 D-Glucuronate 1-phosphate C05411 L-Xylonate C05412 L-Lyxonate C05422 Dehydroascorbate C06316 Dehydro-D-arabinono-1,4-lactone C14899 3-Dehydro-L-gulonate 6-phosphate C15923 L-Gulose C15924 L-Gulose 1-phosphate C15925 GDP-L-gulose C15926 beta-L-Galactose 1-phosphate C15930 L-Galactonate C16186 L-Ascorbate 6-phosphate C20889 D-Galactaro-1,5-lactone C20896 D-Galactaro-1,4-lactone C21955 L-Galactono-1,5-lactone REFERENCE PMID:17222174 AUTHORS Linster CL, Van Schaftingen E TITLE Vitamin C. Biosynthesis, recycling and degradation in mammals. JOURNAL FEBS J 274:1-22 (2007) DOI:10.1111/j.1742-4658.2006.05607.x REFERENCE PMID:15564123 AUTHORS Valpuesta V, Botella MA. TITLE Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant. JOURNAL Trends Plant Sci 9:573-7 (2004) DOI:10.1016/j.tplants.2004.10.002 REFERENCE PMID:10517845 AUTHORS Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC. TITLE Ascorbate biosynthesis in Arabidopsis cell suspension culture. JOURNAL Plant Physiol 121:535-43 (1999) DOI:10.1104/pp.121.2.535 REFERENCE PMID:16595667 AUTHORS Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N. TITLE Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme. JOURNAL J Biol Chem 281:15662-70 (2006) DOI:10.1074/jbc.M601409200 REFERENCE PMID:17462988 AUTHORS Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG. TITLE Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants. JOURNAL J Biol Chem 282:18879-85 (2007) DOI:10.1074/jbc.M702094200 REFERENCE PMID:14996803 AUTHORS Campos E, Baldoma L, Aguilar J, Badia J. TITLE Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli. JOURNAL J Bacteriol 186:1720-8 (2004) DOI:10.1128/JB.186.6.1720-1728.2004 REFERENCE PMID:12644495 AUTHORS Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr. TITLE The ascorbate transporter of Escherichia coli. JOURNAL J Bacteriol 185:2243-50 (2003) DOI:10.1128/JB.185.7.2243-2250.2003 REL_PATHWAY hsa00020 Citrate cycle (TCA cycle) hsa00040 Pentose and glucuronate interconversions hsa00051 Fructose and mannose metabolism hsa00520 Amino sugar and nucleotide sugar metabolism hsa00630 Glyoxylate and dicarboxylate metabolism KO_PATHWAY ko00053 ///