ENTRY       b0004             CDS       T00007
SYMBOL      thrC
NAME        (RefSeq) threonine synthase
ORTHOLOGY   K01733  threonine synthase [EC:4.2.3.1]
ORGANISM    eco  Escherichia coli K-12 MG1655
PATHWAY     eco00260  Glycine, serine and threonine metabolism
            eco00750  Vitamin B6 metabolism
            eco01100  Metabolic pathways
            eco01110  Biosynthesis of secondary metabolites
            eco01120  Microbial metabolism in diverse environments
            eco01230  Biosynthesis of amino acids
MODULE      eco_M00018  Threonine biosynthesis, aspartate => homoserine => threonine
BRITE       KEGG Orthology (KO) [BR:eco00001]
             09100 Metabolism
              09105 Amino acid metabolism
               00260 Glycine, serine and threonine metabolism
                b0004 (thrC)
              09108 Metabolism of cofactors and vitamins
               00750 Vitamin B6 metabolism
                b0004 (thrC)
            Enzymes [BR:eco01000]
             4. Lyases
              4.2  Carbon-oxygen lyases
               4.2.3  Acting on phosphates
                4.2.3.1  threonine synthase
                 b0004 (thrC)
POSITION    3734..5020
MOTIF       Pfam: PALP Thr_synth_N
DBLINKS     NCBI-GeneID: 945198
            NCBI-ProteinID: NP_414545
            Pasteur: thrC
            RegulonDB: ECK120000989
            ECOCYC: EG11000
            ASAP: ABE-0000012
            UniProt: P00934
STRUCTURE   PDB
AASEQ       428
            MKLYNLKDHNEQVSFAQAVTQGLGKNQGLFFPHDLPEFSLTEIDEMLKLDFVTRSAKILS
            AFIGDEIPQEILEERVRAAFAFPAPVANVESDVGCLELFHGPTLAFKDFGGRFMAQMLTH
            IAGDKPVTILTATSGDTGAAVAHAFYGLPNVKVVILYPRGKISPLQEKLFCTLGGNIETV
            AIDGDFDACQALVKQAFDDEELKVALGLNSANSINISRLLAQICYYFEAVAQLPQETRNQ
            LVVSVPSGNFGDLTAGLLAKSLGLPVKRFIAATNVNDTVPRFLHDGQWSPKATQATLSNA
            MDVSQPNNWPRVEELFRRKIWQLKELGYAAVDDETTQQTMRELKELGYTSEPHAAVAYRA
            LRDQLNPGEYGLFLGTAHPAKFKESVEAILGETLDLPKELAERADLPLLSHNLPADFAAL
            RKLMMNHQ
NTSEQ       1287
            atgaaactctacaatctgaaagatcacaacgagcaggtcagctttgcgcaagccgtaacc
            caggggttgggcaaaaatcaggggctgttttttccgcacgacctgccggaattcagcctg
            actgaaattgatgagatgctgaagctggattttgtcacccgcagtgcgaagatcctctcg
            gcgtttattggtgatgaaatcccacaggaaatcctggaagagcgcgtgcgcgcggcgttt
            gccttcccggctccggtcgccaatgttgaaagcgatgtcggttgtctggaattgttccac
            gggccaacgctggcatttaaagatttcggcggtcgctttatggcacaaatgctgacccat
            attgcgggtgataagccagtgaccattctgaccgcgacctccggtgataccggagcggca
            gtggctcatgctttctacggtttaccgaatgtgaaagtggttatcctctatccacgaggc
            aaaatcagtccactgcaagaaaaactgttctgtacattgggcggcaatatcgaaactgtt
            gccatcgacggcgatttcgatgcctgtcaggcgctggtgaagcaggcgtttgatgatgaa
            gaactgaaagtggcgctagggttaaactcggctaactcgattaacatcagccgtttgctg
            gcgcagatttgctactactttgaagctgttgcgcagctgccgcaggagacgcgcaaccag
            ctggttgtctcggtgccaagcggaaacttcggcgatttgacggcgggtctgctggcgaag
            tcactcggtctgccggtgaaacgttttattgctgcgaccaacgtgaacgataccgtgcca
            cgtttcctgcacgacggtcagtggtcacccaaagcgactcaggcgacgttatccaacgcg
            atggacgtgagtcagccgaacaactggccgcgtgtggaagagttgttccgccgcaaaatc
            tggcaactgaaagagctgggttatgcagccgtggatgatgaaaccacgcaacagacaatg
            cgtgagttaaaagaactgggctacacttcggagccgcacgctgccgtagcttatcgtgcg
            ctgcgtgatcagttgaatccaggcgaatatggcttgttcctcggcaccgcgcatccggcg
            aaatttaaagagagcgtggaagcgattctcggtgaaacgttggatctgccaaaagagctg
            gcagaacgtgctgatttacccttgctttcacataatctgcccgccgattttgctgcgttg
            cgtaaattgatgatgaatcatcagtaa
///