ENTRY C01290 Compound NAME Lactosylceramide; beta-D-Galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide; beta-D-Galactosyl-1,4-beta-D-glucosylceramide; Gal-beta1->4Glc-beta1->1'Cer; LacCer; Lactosyl-N-acylsphingosine; D-Galactosyl-1,4-beta-D-glucosylceramide FORMULA C31H56NO13R REMARK Same as: G00092 COMMENT Generic compound in reaction hierarchy REACTION R03354 R03355 R03486 R03488 R03489 R03490 R03491 R03492 R03618 R04493 R12960 R12961 PATHWAY map00600 Sphingolipid metabolism map00601(G00092) Glycosphingolipid biosynthesis - lacto and neolacto series map00603(G00092) Glycosphingolipid biosynthesis - globo and isoglobo series map00604(G00092) Glycosphingolipid biosynthesis - ganglio series map01100 Metabolic pathways MODULE M00066 Lactosylceramide biosynthesis NETWORK nt06014(G00092) Sphingolipid degradation nt06035(G00092) Blood group carbohydrate antigen biosynthesis ENZYME 2.4.1.92 2.4.1.206 2.4.1.228 2.4.1.274 2.4.3.1 2.4.3.9 2.8.2.11 3.1.6.8 3.2.1.18 3.2.1.22 3.2.1.23 3.2.1.52 BRITE Compounds with biological roles [BR:br08001] Lipids Glycolipids Glycosphingolipids C01290 Lactosylceramide Lipids [BR:br08002(G00092)] SP Sphingolipids SP05 Neutral glycosphingolipids SP0501 Simple Glc series G00092 Gal-beta1->4Glc-beta1->1'Cer (LacCer) DBLINKS PubChem: 4509 ChEBI: 17950 ATOM 46 1 C1y C 15.9666 -18.9599 2 C1y C 15.9337 -17.5704 3 O2a O 14.6552 -19.6363 4 C1y C 17.0731 -19.6917 5 O2x O 17.1379 -16.9034 6 C1b C 14.7200 -16.8477 7 C1y C 13.4603 -20.3126 8 C1y C 18.3146 -19.0155 9 O1a O 17.0361 -21.0907 10 C1y C 18.3516 -17.6260 11 O1a O 13.5250 -17.5795 12 O2x O 12.2464 -19.5899 13 C1y C 13.4138 -21.7206 14 O1a O 19.5096 -19.7567 15 O2a O 19.5838 -16.9684 16 C1y C 11.0238 -20.2570 17 C1y C 12.1817 -22.3786 18 O1a O 14.4327 -22.2303 19 C1b C 20.8066 -17.6631 20 C1y C 10.9958 -21.6650 21 C1b C 9.8285 -19.5342 22 O1a O 12.1446 -23.7866 23 C1c C 22.0202 -16.9404 24 O1a O 9.7361 -22.3415 25 O1a O 8.6335 -20.2570 26 C1c C 23.2614 -17.6351 27 N1b N 22.0108 -15.5323 28 C2b C 24.4844 -16.9128 29 O1a O 23.2708 -19.0435 30 C5a C 23.2152 -14.8191 31 C2b C 25.7073 -17.6074 32 O5a O 23.2666 -13.4107 33 R R 24.4473 -15.5044 34 C1b C 26.9207 -16.8942 35 C1b C 28.1529 -17.5889 36 C1b C 29.3758 -16.8663 37 C1b C 30.5987 -17.5610 38 C1b C 31.8216 -16.8386 39 C1b C 33.0537 -17.5242 40 C1b C 34.2672 -16.8107 41 C1b C 35.4993 -17.5056 42 C1b C 36.7128 -16.7921 43 C1b C 37.9543 -17.4777 44 C1b C 39.1678 -16.7736 45 C1b C 40.4001 -17.4591 46 C1a C 41.6137 -16.7459 BOND 47 1 1 2 1 2 1 3 1 #Down 3 1 4 1 4 2 5 1 5 2 6 1 #Up 6 7 3 1 #Up 7 4 8 1 8 4 9 1 #Up 9 5 10 1 10 6 11 1 11 7 12 1 12 7 13 1 13 8 14 1 #Down 14 10 15 1 #Up 15 12 16 1 16 13 17 1 17 13 18 1 #Down 18 15 19 1 19 16 20 1 20 16 21 1 #Up 21 17 22 1 #Up 22 19 23 1 23 20 24 1 #Up 24 21 25 1 25 23 26 1 26 23 27 1 #Down 27 26 28 1 28 26 29 1 #Up 29 27 30 1 30 28 31 2 31 30 32 2 32 30 33 1 33 31 34 1 34 34 35 1 35 35 36 1 36 36 37 1 37 37 38 1 38 38 39 1 39 39 40 1 40 40 41 1 41 41 42 1 42 42 43 1 43 43 44 1 44 44 45 1 45 45 46 1 46 8 10 1 47 17 20 1 /// ENTRY G00092 Glycan NAME Lactosylceramide; LacCer; CD17 COMPOSITION (Gal)1 (Glc)1 (Cer)1 MASS 324.3 (Cer) REMARK Same as: C01290 REACTION R05937 R05938 R05960 R05961 R05971 R05999 R06001 R06099 R06121 R06276 R11320 PATHWAY map00601 Glycosphingolipid biosynthesis - lacto and neolacto series map00603 Glycosphingolipid biosynthesis - globo and isoglobo series map00604 Glycosphingolipid biosynthesis - ganglio series MODULE M00068 Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer M00069 Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3 M00070 Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer M00071 Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer NETWORK nt06014 Sphingolipid degradation nt06035 Blood group carbohydrate antigen biosynthesis ENZYME 2.4.1.87 2.4.1.92 2.4.1.206 2.4.1.228 2.4.1.274 2.4.3.1 2.4.3.9 3.2.1.18 3.2.1.22 3.2.1.23 3.2.1.52 BRITE Compounds with biological roles [BR:br08001] Lipids Glycolipids Glycosphingolipids C01290 Lactosylceramide CD molecules [BR:ko04090] Carbohydrates G00092 CD17; CD17, lactosylceramide, LacCer Lipids [BR:br08002] SP Sphingolipids SP05 Neutral glycosphingolipids SP0501 Simple Glc series G00092 Gal-beta1->4Glc-beta1->1'Cer (LacCer) REFERENCE 1 [PMID:3392043] AUTHORS Larson G, Falk P, Hoskins LC. TITLE Degradation of human intestinal glycosphingolipids by extracellular glycosidases from mucin-degrading bacteria of the human fecal flora. JOURNAL J Biol Chem 263:10790-8 (1988) REFERENCE 2 [PMID:14631106] AUTHORS Wu AM. TITLE Carbohydrate structural units in glycoproteins and polysaccharides as important ligands for Gal and GalNAc reactive lectins. JOURNAL J Biomed Sci 10:676-88 (2003) DOI:10.1159/000073954 REFERENCE 3 [PMID:2960671] AUTHORS Holmes EH, Hakomori S, Ostrander GK. TITLE Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase. JOURNAL J Biol Chem 262:15649-58 (1987) REFERENCE 4 [PMID:15546874] AUTHORS Ideo H, Seko A, Yamashita K. TITLE Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells. JOURNAL J Biol Chem 280:4730-7 (2005) DOI:10.1074/jbc.M410362200 DBLINKS CCSD: 83 84 2309 3311 3312 3314 4656 4728 5270 5511 5721 7517 9378 9972 10020 10305 11327 11408 11611 11640 11800 12377 14422 14495 14875 15723 15901 16352 16402 16459 16571 16867 17112 17685 17711 18546 18588 19340 20904 22110 23020 24110 24125 24437 24647 24765 24980 24987 25039 25254 25319 25327 25415 25635 25918 26178 26266 26397 26587 26596 26613 26735 27272 27460 27539 27631 27665 27667 27668 28496 28551 28993 29095 29267 29288 29400 29413 29704 29910 29959 29988 30832 30871 31629 31689 31974 32046 32547 32590 32592 32679 32729 32736 32739 32888 32927 33058 33106 33184 33203 33206 33244 33403 33465 33524 33586 33673 33711 33807 33894 34168 34751 35120 35270 35315 35363 35552 35591 35920 35948 35993 36113 36144 36163 36217 36282 36460 36581 36643 36655 36859 36981 36986 36990 36997 37006 37051 37061 37074 37089 37243 37260 37401 37603 37838 38058 38087 38089 38110 38140 38537 38674 39382 39519 39662 40781 40815 41776 41868 41900 42042 42730 42915 42981 43024 43460 43579 43795 44037 44063 44081 44242 44498 44962 44991 45299 45662 46197 46400 46801 46839 47203 47380 47423 47598 47631 47659 47700 47736 47855 48195 48203 48252 48376 48600 48901 49326 49446 49510 50270 GlyTouCan: G84224TW LIPIDMAPS: LMSP0501AB00 JCGGDB: JCGG-STR001961 GlycoEpitope: EP0068 EP0078 NODE 3 1 Cer 9 0 2 Glc 0 0 3 Gal -9 0 EDGE 2 1 2:b1 1:1 2 3:b1 2:4 ///