ENTRY C00022 Compound NAME Pyruvate; Pyruvic acid; 2-Oxopropanoate; 2-Oxopropanoic acid; Pyroracemic acid FORMULA C3H4O3 EXACT_MASS 88.0160 MOL_WEIGHT 88.06 REACTION R00006 R00008 R00014 R00195 R00196 R00197 R00198 R00199 R00200 R00203 R00205 R00206 R00207 R00208 R00209 R00210 R00211 R00212 R00213 R00214 R00215 R00216 R00217 R00218 R00219 R00220 R00221 R00223 R00224 R00226 R00237 R00258 R00297 R00324 R00325 R00344 R00350 R00353 R00368 R00369 R00396 R00398 R00400 R00409 R00430 R00452 R00453 R00470 R00471 R00532 R00543 R00562 R00572 R00576 R00585 R00659 R00666 R00673 R00692 R00703 R00704 R00724 R00728 R00750 R00782 R00906 R00907 R00930 R00985 R00986 R01012 R01031 R01032 R01064 R01085 R01138 R01147 R01148 R01196 R01215 R01261 R01286 R01302 R01335 R01344 R01355 R01447 R01576 R01584 R01645 R01647 R01683 R01699 R01712 R01782 R01784 R01811 R01858 R01874 R02050 R02261 R02271 R02293 R02320 R02408 R02628 R02721 R02754 R02953 R02970 R03001 R03037 R03050 R03081 R03105 R03145 R03277 R03465 R03502 R03528 R03732 R03796 R03854 R04152 R04187 R04350 R04672 R04861 R04941 R05136 R05298 R05538 R05544 R05553 R05605 R05636 R05648 R05652 R05861 R06602 R06603 R06913 R06923 R06934 R07399 R07633 R07634 R07685 R07692 R07713 R08166 R08170 R08197 R08200 R08253 R08570 R08648 R08654 R08660 R08667 R08686 R08698 R08714 R09048 R09088 R09238 R09254 R09366 R10147 R10178 R10180 R10283 R10487 R10527 R10539 R10542 R10550 R10552 R10583 R10597 R10616 R10674 R10691 R10866 R10992 R11023 R11038 R11099 R11141 R11213 R11257 R11352 R11463 R11591 R11593 R11676 R11864 R11996 R12188 R12212 R12237 R12343 R12622 R12689 R12707 R12768 R13049 R13050 R13181 R13209 PATHWAY map00010 Glycolysis / Gluconeogenesis map00020 Citrate cycle (TCA cycle) map00030 Pentose phosphate pathway map00040 Pentose and glucuronate interconversions map00053 Ascorbate and aldarate metabolism map00250 Alanine, aspartate and glutamate metabolism map00260 Glycine, serine and threonine metabolism map00261 Monobactam biosynthesis map00270 Cysteine and methionine metabolism map00290 Valine, leucine and isoleucine biosynthesis map00330 Arginine and proline metabolism map00350 Tyrosine metabolism map00360 Phenylalanine metabolism map00362 Benzoate degradation map00430 Taurine and hypotaurine metabolism map00440 Phosphonate and phosphinate metabolism map00470 D-Amino acid metabolism map00620 Pyruvate metabolism map00621 Dioxin degradation map00622 Xylene degradation map00630 Glyoxylate and dicarboxylate metabolism map00650 Butanoate metabolism map00660 C5-Branched dibasic acid metabolism map00680 Methane metabolism map00710 Carbon fixation by Calvin cycle map00720 Other carbon fixation pathways map00730 Thiamine metabolism map00760 Nicotinate and nicotinamide metabolism map00770 Pantothenate and CoA biosynthesis map00785 Lipoic acid metabolism map00900 Terpenoid backbone biosynthesis map00997 Biosynthesis of various other secondary metabolites map00998 Biosynthesis of various antibiotics map01060 Biosynthesis of plant secondary metabolites map01061 Biosynthesis of phenylpropanoids map01062 Biosynthesis of terpenoids and steroids map01063 Biosynthesis of alkaloids derived from shikimate pathway map01064 Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid map01065 Biosynthesis of alkaloids derived from histidine and purine map01066 Biosynthesis of alkaloids derived from terpenoid and polyketide map01070 Biosynthesis of plant hormones map01100 Metabolic pathways map01110 Biosynthesis of secondary metabolites map01120 Microbial metabolism in diverse environments map01200 Carbon metabolism map01210 2-Oxocarboxylic acid metabolism map01220 Degradation of aromatic compounds map01230 Biosynthesis of amino acids map01240 Biosynthesis of cofactors map01502 Vancomycin resistance map02020 Two-component system map02060 Phosphotransferase system (PTS) map04066 HIF-1 signaling pathway map04152 AMPK signaling pathway map04911 Insulin secretion map04922 Glucagon signaling pathway map04930 Type II diabetes mellitus map04931 Insulin resistance map05230 Central carbon metabolism in cancer map05415 Diabetic cardiomyopathy MODULE M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate M00002 Glycolysis, core module involving three-carbon compounds M00008 Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine M00061 D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P M00096 C5 isoprenoid biosynthesis, non-mevalonate pathway M00169 CAM (Crassulacean acid metabolism), light M00171 C4-dicarboxylic acid cycle, NAD - malic enzyme type M00172 C4-dicarboxylic acid cycle, NADP - malic enzyme type M00173 Reductive citrate cycle (Arnon-Buchanan cycle) M00307 Pyruvate oxidation, pyruvate => acetyl-CoA M00308 Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P M00309 Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate M00374 Dicarboxylate-hydroxybutyrate cycle M00376 3-Hydroxypropionate bi-cycle M00535 Isoleucine biosynthesis, pyruvate => 2-oxobutanoate M00569 Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA M00620 Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate M00631 D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P M00633 Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P M00975 Betaine degradation, bacteria, betaine => pyruvate NETWORK nt06031 Citrate cycle and pyruvate metabolism nt06032 Lipoic acid metabolism nt06166 Human papillomavirus (HPV) ENZYME 1.1.1.27 1.1.1.28 1.1.1.38 1.1.1.39 1.1.1.40 1.1.1.83 1.1.1.436 1.1.2.3 1.1.2.4 1.1.2.5 1.1.3.2 1.1.5.12 1.1.99.6 1.1.99.7 1.1.99.40 1.2.1.22 1.2.1.23 1.2.1.49 1.2.1.51 1.2.1.104 1.2.3.3 1.2.3.6 1.2.3.15 1.2.4.1 1.2.5.1 1.2.7.1 1.2.7.11 1.2.7.- 1.4.1.1 1.4.1.17 1.4.3.3 1.4.3.19 1.5.1.11 1.5.1.16 1.5.1.17 1.5.1.22 1.5.1.23 1.5.1.24 1.5.1.26 1.5.1.28 1.5.1.52 1.14.11.43 1.14.11.44 2.1.3.1 2.2.1.6 2.2.1.7 2.2.1.12 2.3.1.54 2.3.3.21 2.6.1.2 2.6.1.12 2.6.1.15 2.6.1.18 2.6.1.21 2.6.1.30 2.6.1.37 2.6.1.40 2.6.1.41 2.6.1.43 2.6.1.44 2.6.1.46 2.6.1.47 2.6.1.51 2.6.1.56 2.6.1.58 2.6.1.66 2.6.1.71 2.6.1.77 2.6.1.84 2.6.1.96 2.6.1.99 2.6.1.108 2.6.1.113 2.6.1.115 2.6.1.119 2.6.3.1 2.7.1.40 2.7.1.121 2.7.3.9 2.7.9.1 2.7.9.2 2.8.1.2 3.1.3.60 3.3.2.1 3.3.2.13 3.3.2.15 3.5.99.10 3.7.1.5 3.7.1.6 3.7.1.20 3.7.1.23 3.7.1.26 3.7.1.- 3.11.1.3 4.1.1.1 4.1.1.64 4.1.1.78 4.1.1.112 4.1.1.- 4.1.2.14 4.1.2.18 4.1.2.20 4.1.2.21 4.1.2.23 4.1.2.28 4.1.2.34 4.1.2.45 4.1.2.51 4.1.2.52 4.1.2.53 4.1.2.54 4.1.2.55 4.1.2.58 4.1.2.64 4.1.2.- 4.1.3.3 4.1.3.16 4.1.3.17 4.1.3.22 4.1.3.25 4.1.3.27 4.1.3.30 4.1.3.32 4.1.3.38 4.1.3.39 4.1.3.40 4.1.3.42 4.1.3.43 4.1.3.44 4.1.3.45 4.1.3.46 4.1.99.1 4.1.99.2 4.2.1.- 4.2.99.20 4.2.99.21 4.3.1.10 4.3.1.13 4.3.1.15 4.3.1.17 4.3.1.18 4.3.1.19 4.3.3.7 4.3.3.8 4.4.1.1 4.4.1.13 4.4.1.15 4.4.1.24 4.4.1.25 4.4.1.28 4.4.1.35 4.4.1.36 4.4.1.- 4.5.1.2 6.4.1.1 7.2.4.2 BRITE Compounds with biological roles [BR:br08001] Organic acids Carboxylic acids 2-Oxocarboxylic acids C00022 Pyruvate; 2-Oxopropanoate Lipids [BR:br08002] FA Fatty acyls FA01 Fatty Acids and Conjugates FA0106 Oxo fatty acids C00022 2-Oxopropanoic acid DBLINKS CAS: 127-17-3 PubChem: 3324 ChEBI: 15361 32816 LIPIDMAPS: LMFA01060077 KNApSAcK: C00001200 PDB-CCD: PYR NIKKAJI: J2.015J ATOM 6 1 C1a C 12.6924 -17.4300 2 C5a C 13.9049 -16.7300 3 C6a C 15.1173 -17.4300 4 O6a O 16.3318 -16.7288 5 O5a O 13.9049 -15.3302 6 O6a O 15.1173 -18.8300 BOND 5 1 1 2 1 2 2 3 1 3 3 4 1 4 2 5 2 5 3 6 2 ///